CARDIOVASCULAR STATE MONITORING - DRUG DELIVERY APPARATUS AND METHOD OF USE THEREOF

1 . A method for operating a drug delivery system, comprising the steps of:

receiving to said drug delivery system a first time-varying cardiovascular input waveform from at least one of:

a pulse oximeter; and

a blood pressure monitor;

operating on the time-varying cardiovascular input waveform to generate transient cardiovascular state information, comprising at least one of:

a current left ventricle stroke volume;

a current blood pressure;

a current arterial compliance; and

a current blood flow rate; and

directing said drug delivery system to deliver a drug based on the generated transient cardiovascular state information.

2 . The method of claim 1 , further comprising the steps of:

said step of receiving further comprising a step of receiving time varying pressure data from an alternating: (1) partial inflation of a blood pressure cuff in a range of 80 to 160 mm Hg and (2) a partial deflation of said blood pressure cuff in a range of 30 to 60 mm Hg generated from a pressure transducer output of said blood pressure monitor; and

said step of operating determining a pulse from said time varying pressure data.

3 . The method of claim 1 , said step of receiving comprising the step of:

receiving the first time-varying cardiovascular input waveform from said pulse oximeter; and

receiving a second time-varying cardiovascular input waveform from said blood pressure monitor.

4 . The method of claim 1 , said step of receiving further comprising the step of:

receiving to said drug delivery system a second time-varying cardiovascular input waveform from an electrocardiogram device.

5 . The method of claim 1 , said step of receiving further comprising the step of receiving state sensor input from at least one of:

an oxygen sensor;

a blood oxygen sensor;

a glucose sensor;

a glucose concentration sensor;

a heart rate sensor; and

an adrenaline sensor.

6 . The method of claim 1 , said step of directing further comprising the step of:

altering a flow rate of at least one of:

an infusion pump; and

a dosing pump.

7 . The method of claim 6 , further comprising the steps of:

said step of operating further comprising the step of monitoring a change in blood pressure with the first time-varying cardiovascular input waveform; and

iteratively changing a flow rate of a blood pressure altering drug through said infusion pump to alter an observed blood flow rate toward a target blood flow rate.

8 . The method of claim 6 , further comprising the steps of:

said step of operating, alternatingly sensing an increase and a decrease of at least one of an observed blood flow rate and an observed blood pressure with the first time-varying cardiovascular input waveform; and

altering delivery of a first drug and a second drug through a set of infusion pumps comprising said infusion pump to alternatingly counter the observed increase and decrease of the observed blood flow rate toward a target blood flow rate and the observed blood pressure toward a target blood pressure.

9 . The method of claim 6 , further comprising the steps of:

sensing a change in glucose concentration with a glucose meter; and

changing by at least five percent a flow rate of a glucose infusion pump.

10 . The method of claim 6 , further comprising the steps of:

sensing a change in activity with an activity sensor resulting in a change to a target blood flow rate; and

changing a flow rate of a drug delivery from said infusion pump to alter an observed blood flow toward the target blood flow rate.

11 . The method of claim 6 , further comprising the steps of:

receiving a first user input setting to an inactive state at a first time, said inactive state comprising at least one of: a sleeping state, a resting state, a laying state, a sitting state, and a passive state;

receiving a second user input setting to an active state at a second time, said active state comprising at least one of a walking state, an exercise state, and a climbing state;

setting a total target blood flow rate to match a set activity of a most recent activity setting of said first user input setting and said second user input setting; and

iteratively changing a flow rate of a blood pressure altering drug through said infusion pump to alter an observed blood flow rate toward the target blood flow rate.

12 . The method of claim 1 , further comprising the step of:

dynamically controlling an infusion pump, said step of dynamically controlling comprising the step of repeating each of: said step of receiving input data, said step of operating to update said transient cardiovascular state information, and said step of directing.

13 . The method of claim 1 , said step of directing further comprising the step of:

changing a flow rate of an infusion pump.

14 . The method of claim 1 , said step of directing further comprising the step of:

altering a dosage delivery rate of a dosing pump by at least one percent.

15 . The method of claim 1 , further comprising the step of:

sensing activity with an activity sensor to generate a target cardiovascular state; and

said step of directing, based upon an observed blood state, altering a delivery rate of a drug.

16 . The method of claim 1 , further comprising the step of:

receiving second input data comprising time-varying activity input data from an activity sensor.

17 . The method of claim 1 , said step of directing further comprising the step of:

communicating a pill to dispense.

18 . The method of claim 1 , said step of directing further comprising the step of:

directing both a cardiac assist pump and an infusion pump.

19 . An apparatus for delivering a drug, comprising:

a drug monitoring system comprising at least one of a pulse oximeter and a blood pressure monitor, said drug monitoring system configured to generate a first time-varying cardiovascular input waveform from at least one of said pulse oximeter and said blood pressure monitor,

said drug monitoring system configured to operate on the time-varying cardiovascular input waveform to generate transient cardiovascular state information, comprising at least one of:

a current left ventricle stroke volume;

a current blood pressure;

a current arterial compliance; and

a current blood flow rate; and

said drug monitoring system, communicatively coupled to a drug delivery system, configured to direct a dispensed product based on the generated transient cardiovascular state information.

20 . The apparatus of claim 19 , said transient cardiovascular state information comprising:

said current left ventricle stroke volume.