Substituted diazaspiroalkanes as androgen receptor modulators
Provided herein are hydantoin compounds useful for the prevention or treatment of hyperproliferative diseases or disorders. Exemplary hydantoin compounds include substituted diazaspiroalkanes, such as (A51) and (A52) having the following structures:
1. A method for treating a hyperproliferative disorder in a subject in need thereof, wherein the method comprises administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and:
(i) from 0.0005 mg to 500 mg of a compound having the following formula:
or a pharmaceutically acceptable salt thereof; or
(ii) from 0.0005 mg to 500 mg of a compound having the following formula:
or a pharmaceutically acceptable salt thereof;
wherein the pharmaceutical composition is formulated as a capsule or a tablet.
2. The method of claim 1 , wherein the hyperproliferative disorder is related to androgen receptor activity.
3. The method of claim 1 , wherein the hyperproliferative disorder is prostate cancer.
4. The method of claim 3 , wherein the prostate cancer is hormone refractory prostate cancer.
5. The method of claim 3 , wherein the prostate cancer is hormone sensitive prostate cancer.
6. The method of claim 1 , wherein the pharmaceutical composition comprises from 0.0005 mg to 500 mg of the compound having the following formula:
or a pharmaceutically acceptable salt thereof.
7. The method of claim 1 , wherein the pharmaceutical composition is formulated as a capsule.
8. The method of claim 1 , wherein the pharmaceutical composition is formulated as a tablet.
9. A method for treating a hyperproliferative disorder in a subject in need thereof, wherein the method comprises administering to the subject a pill comprising a pharmaceutically acceptable carrier and:
(i) from 0.0005 mg to 500 mg of a compound having the following formula:
or a pharmaceutically acceptable salt thereof; or
(ii) from 0.0005 mg to 500 mg of a compound having the following formula:
or a pharmaceutically acceptable salt thereof.
10. The method of claim 9 , wherein the hyperproliferative disorder is prostate cancer.
11. The method of claim 10 , wherein the prostate cancer is hormone refractory prostate cancer.
12. The method of claim 10 , wherein the prostate cancer is hormone sensitive prostate cancer.
13. The method of claim 9 , wherein the pill is a time release pill.
14. A method for treating a hyperproliferative disorder in a subject in need thereof, wherein the method comprises administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and from 0.0005 mg to 500 mg of a compound having the following formula:
or a pharmaceutically acceptable salt thereof;
wherein the pharmaceutical composition is formulated as a capsule or a tablet.
15. The method of claim 14 , wherein the hyperproliferative disorder is related to androgen receptor activity.
16. The method of claim 14 , wherein the hyperproliferative disorder is prostate cancer.
17. The method of claim 16 , wherein the prostate cancer is hormone refractory prostate cancer.
18. The method of claim 16 , wherein the prostate cancer is hormone sensitive prostate cancer.
19. The method of claim 14 , wherein the pharmaceutical composition is formulated as a capsule.
20. The method of claim 14 , wherein the pharmaceutical composition is formulated as a tablet.
21. A method for treating prostate cancer in a subject in need thereof, wherein the method comprises administering to the subject a capsule comprising a pharmaceutically acceptable carrier and from 0.0005 mg to 500 mg of a compound having the following formula:
or a pharmaceutically acceptable salt thereof.
22. The method of claim 21 , wherein the prostate cancer is hormone refractory prostate cancer.
23. The method of claim 21 , wherein the prostate cancer is hormone sensitive prostate cancer.
24. The method of claim 21 , wherein the capsule is a time release capsule.
25. A method for treating prostate cancer in a subject in need thereof, wherein the method comprises administering to the subject a tablet comprising a pharmaceutically acceptable carrier and from 0.0005 mg to 500 mg of a compound having the following formula:
or a pharmaceutically acceptable salt thereof.
26. The method of claim 25 , wherein the prostate cancer is hormone refractory prostate cancer.
27. The method of claim 25 , wherein the prostate cancer is hormone sensitive prostate cancer.
28. The method of claim 25 , wherein the tablet is a time release tablet.