IP Library Granted Patent US 12,508,343
Granted Patent B2
US 12,508,343 · App. 17/098,580 · Granted Dec 30, 2025

Solid forms for tissue repair

Inventors: Nir Altschuler (Hod Hasharon, IL); Razi Vago (Lehavim, IL)
Assignee: CARTIHEAL (2009) LTD.
A61L27/025A61F2/28A61F2/30756A61L27/18A61L27/20A61L27/34A61L27/3604A61L27/3834A61L27/3847A61L27/3852A61L27/427A61L27/52A61L27/54A61L27/56A61F2002/30011A61F2002/30224A61F2002/30807A61F2002/3092A61F2/3094A61F2230/0069A61F2250/0023A61F2310/00341A61L2300/414A61L2300/606A61L2430/02A61L2430/06
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Quick Facts
Patent No.
US 12,508,343
App. No.
17/098,580
Granted
Dec 30, 2025
Kind
B2
Abstract

This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.

Claims (28)

1 . A bi-phasic scaffold for tissue repair, said bi-phasic scaffold having two phases wherein:

a first phase of said two phases comprises solid coral and said first phase further comprises a series of hollows each extending in the same orientation along a longitudinal axis in said first phase;

a second phase of said two phases consisting of the solid coral, the second phase being devoid of the series of hollows;

wherein said hollows have a diameter ranging from about 125 to 650 mm and a height that extends entirely through the first phase, and wherein said first phase has a height of between 1-7 mm.

2 . The bi-phasic scaffold of claim 1 , wherein said bi-phasic scaffold further comprises a cytokine, a chelator, a cell population, an anti-inflammatory compound, an anti-infective compound, a growth factor, an antibiotic, a pro-angiogenic factor, a therapeutic compound, or any combination thereof.

3 . The bi-phasic scaffold of claim 2 , wherein said cell population comprises mesenchymal stem cells, osteoblasts, osteocytes, osteoclasts, chondroblasts, chondrocytes, fibroblasts, or a combination thereof, or other cells involved in cartilage or bone repair.

4 . The bi-phasic scaffold of claim 2 , wherein said growth factor is epidermal growth factor (EGF), transforming growth factor-beta (TGF-β), human endothelial cell growth factor (ECGF), granulocyte macrophage colony stimulating factor (GM-CSF), bone morphogenetic protein (BMP), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), insulin-like growth factor (IGF), cartilage derived morphogenetic protein (CDMP), platelet derived growth factor (PDGF), or a combination thereof.

5 . The bi-phasic scaffold of claim 1 , wherein said bi-phasic scaffold approximates the form of a cylinder, cone, screw, rectangular bar, plate, disc, pyramid, granule, ball or cube.

6 . The bi-phasic scaffold of claim 1 , wherein the bi-phasic scaffold assumes a shape to approximate a meniscus for a knee or elbow; a joint; an articular surface of a bone, a portion of a rib cage, a hip, a pelvis, an ear, a nose, a ligament, a bronchial tube or an intervertebral disc.

7 . The bi-phasic scaffold of claim 1 , wherein said bi-phasic scaffold is cylindrical in shape and has a diameter of about 5-40 mm, and a height of about 5-25 mm.

8 . The bi-phasic scaffold of claim 1 , wherein the bi-phasic scaffold includes a tapered outer sidewall.

9 . A kit for repair of cartilage or bone comprising the bi-phasic scaffold of claim 1 , and directions for utilizing said bi-phasic scaffold in tissue repair.

10 . The kit of claim 9 , which further comprises a tool or tools for optimal insertion of said bi-phasic scaffold.

11 . The kit of claim 9 , which further comprises a series of bi-phasic scaffolds of different sizes or shapes.

12 . The kit of claim 9 , which further comprises a tool or tools for optimal insertion of said bi-phasic scaffold, and a series of bi-phasic scaffolds of different sizes or shapes.

13 . A method of inducing or enhancing repair, regeneration or enhancement of formation of cartilage, bone or a combination thereof, said method comprising implanting in a subject, a bi-phasic scaffold within a site in need of repair, regeneration or enhancement of formation of cartilage, bone or a combination thereof in said subject, wherein said bi-phasic scaffold has two phases wherein:

a first phase of said two phases comprises solid coral and said first phase further comprises a series of hollows each extending in the same orientation along a longitudinal axis in said first phase; and

a second phase of said two phases consisting of the solid coral, the second phase being devoid of the series of hollows,

wherein said hollows have a diameter ranging from about 125 to 650 μm and a height that extends entirely through the first phase, and wherein said first phase has a height of between 1-7 mm.

14 . The method of claim 13 , wherein said inducing or enhancing repair, regeneration or enhancement of formation of cartilage, bone or a combination thereof relates to a cartilage defect or disorder in a subject, comprising a full or partial thickness articular cartilage defect; osteochondral defect; osteoarthritis; osteochondritis dissecans; a joint defect; or a defect resulting from trauma, sports, or repetitive stress.

15 . The method of claim 13 , wherein said bi-phasic scaffold is positioned such that said first phase is implanted within or proximally to cartilage tissue and said second phase is implanted within or proximally to bone tissue, and wherein said first phase is directly atop said second phase.

16 . The method of claim 13 , wherein the bi-phasic scaffold includes a tapered outer sidewall.

17 . A method of inducing or enhancing repair, regeneration or enhancement of formation of cartilage, bone or a combination thereof, said method comprising:

implanting in a subject, a bi-phasic scaffold within a site in need of repair, regeneration or enhancement of formation of cartilage, bone or a combination thereof in said subject, said bi-phasic scaffold has two phases:

a first phase of said two phases comprising solid coral and a series of straight hollows each extending in the same orientation along a longitudinal axis in said first phase; and

a second phase of said two phases consisting of the solid coral, the second phase being devoid of the series of straight hollows, wherein the biphasic scaffold includes a tapered outer sidewall;

wherein said straight hollows have a diameter ranging from about 125 to 650 μm and a height that extends entirely through the first phase, and wherein said first phase has a height of between 1-7 mm, wherein said first phase is atop said second phase, and wherein said bi-phasic scaffold is positioned such that said first phase is implanted within or proximally to cartilage tissue and said second phase is implanted within or proximally to bone tissue.

18 . The method of claim 17 , wherein said inducing or enhancing repair, regeneration or enhancement of formation of cartilage, bone or a combination thereof relates to a cartilage defect or disorder comprising a full or partial thickness articular cartilage defect; osteochondral defect; osteoarthritis; osteochondritis dissecans; a joint defect; or a defect resulting from trauma, sports, or repetitive stress.

Assignments (3)
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT COLLATERAL RECORDED AT REEL 060633, FRAME 0207 Recorded Oct 23, 2023
From: ELRON VENTURES LTD., AS SECURITYHOLDER REPRESENTATIVE, ADMINISTRATIVE AGENT AND COLLATERAL AGENT
To: CARTIHEAL (2009) LTD.
Reel/Frame 065320/0248 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Jul 12, 2022
From: CARTIHEAL (2009) LTD.
To: ELRON VENTURES LTD., AS ADMINISTRATIVE AGENT
Reel/Frame 060633/0207 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 5, 2021
From: ALTSCHULER, NIR; VAGO, RAZI
To: CARTIHEAL (2009) LTD
Reel/Frame 055161/0494 →
Continuity (6)
Continuation 16107547 · Aug 21, 2018
Continuation 14302184 · Jun 11, 2014
Continuation 13378474
Provisional Application 61252800 · Oct 19, 2009
Provisional Application 61187081 · Jun 15, 2009
Related Publication 20210077657A1 · Mar 18, 2021
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