Methods for photodynamic therapy
A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.
1. A method of performing photodynamic therapy using a topical composition including 5-aminolevulinic acid hydrochloride in gel form, the method comprising:
medically treating actinic keratosis by
topically applying the composition to a treatment area comprising an actinic keratosis lesion to be treated with photodynamic therapy;
after the composition is applied to the treatment area, and prior to light treatment, covering the treatment area with a dressing by conforming the dressing to the treatment area such that the dressing stays close to the surface of the treatment area;
maintaining the dressing in place over the treatment area for 3 hours±10%, thereby reducing transepidermal water loss from the treatment area; and
illuminating the treatment area with light having a wavelength of 635 nm±10%.
2. The method of claim 1 , wherein illuminating the treatment area comprises illumination with a dose of light of 37 J/cm 2 ±10%.
3. The method of claim 1 , wherein the illuminating further comprises, within 3 hours±10% from a time when the treatment area is covered with the dressing, illuminating the treatment area with an adjustable illuminator, wherein the treatment area is located on the face, the scalp, or an upper extremity of a patient.
4. The method of claim 3 , wherein the illuminator is located between two to four inches from the treatment area.
5. The method of claim 3 , further comprising sensing, with a sensor, a position of the illuminator.
6. The method of claim 1 , wherein the illumination of the treatment area comprises exposing the treatment area to light from an LED light source.
7. The method of claim 1 , further comprising removing the dressing from the treatment area prior to the illumination.
8. The method of claim 1 , further comprising maintaining the dressing on the treatment area during the illumination.
9. The method of claim 1 , wherein the dressing comprises a primary dressing and a secondary dressing.
10. The method of claim 9 , wherein the secondary dressing is positioned over the primary dressing.
11. The method of claim 10 , wherein the secondary dressing exerts pressure on the primary dressing so as to maintain the primary dressing in place.
12. The method of claim 1 , wherein the treatment area is on an extensor surface of an upper extremity.
13. The method of claim 1 , further comprising sensing, with a sensor, the size of the treatment area.
14. A method of performing photodynamic therapy using a topical composition including 5-aminolevulinic acid hydrochloride, the method comprising:
medically treating actinic keratosis by
topically applying the composition to a treatment area comprising an actinic keratosis lesion to be treated with photodynamic therapy;
after the composition is applied to the treatment area, and prior to light treatment, covering the treatment area with a dressing by conforming the dressing to the treatment area such that the dressing stays close to the surface of the treatment area;
maintaining the dressing in place over the treatment area for 3 hours±10%, thereby reducing transepidermal water loss from the treatment area; and
illuminating the treatment area with light having a wavelength of 417 nm±5 nm.
15. The method of claim 14 , wherein the dressing fits over and around the treatment area and comprises a cylindrical portion.
16. A method of performing photodynamic therapy using a topical composition including 5-aminolevulinic acid hydrochloride in gel form, the method comprising:
medically treating actinic keratosis by
topically applying the composition to a treatment area comprising an actinic keratosis lesion to be treated with photodynamic therapy;
after the composition is applied to the treatment area, and after wetting the treatment area with the composition prior to light treatment, covering the treatment area with a dressing by conforming the dressing to the treatment area such that the dressing stays close to the surface of the treatment area;
maintaining the dressing in place over the treatment area, thereby reducing transepidermal water loss from the treatment area; and
illuminating the treatment area with light having a wavelength of 635 nm±10%.
17. The method of claim 16 , wherein the dressing comprises a sleeve.
18. The method of claim 16 , wherein the dressing wraps around the treatment area and has electrostatic properties.