Additive manufacturing device for biomaterials
An additive manufacturing (AM) device for biomaterials comprises a reservoir, a shaft, and a material delivery head. The device can be used for intracorporeal additive manufacturing. Material within the reservoir can be expelled by a mechanical transmission element, for example a syringe pump, a peristaltic pump, an air pressure pump, or a hydraulic pressure pump. The reservoir can be a barrel, a cartridge, or a cassette. The reservoir can narrow into the shaft, and the shaft can terminate into the nozzle. The shaft can house an inner tube. The device can have an actuator joint capable of being mechanically linked to a robotic surgical system. The actuator joint can have a motor that drives the mechanical transmission element.
1. A method for printing a tissue engineering construct inside a patient's body using a robotic surgical system having an articulating arm and an end effector coupled to a distal end of the articulating arm, the end effector configured to have at least three degrees of movement being controlled by the robotic surgical system, the method comprising:
providing an additive manufacturing device releasably mounted to the end effector, the additive manufacturing device including a first mechanical transmission element engaged with the end effector, a biomaterial reservoir filled with biomaterial and operatively coupled to the first mechanical transmission element, and a nozzle in fluid communication with the biomaterial reservoir;
inserting the nozzle into the patient's body proximate a surgical site;
operating the end effector so as to expel the biomaterial out of the nozzle to thereby deposit the biomaterial at the surgical site; and
commanding the end effector to move the nozzle while depositing the biomaterial to print a tissue engineering construct at the surgical site inside the patient's body.
2. The method of claim 1 , wherein the additive manufacturing device further includes:
an articulating joint operatively coupled to the nozzle, the articulating joint has at least one degree of freedom of movement; and
a second mechanical transmission element operatively coupled to the articulating joint and engaged with the end effector, the method further comprising:
commanding the end effector to move the nozzle corresponding to the least one degree of freedom of movement of the articulating joint while printing the tissue engineering construct.
3. The method of claim 1 , wherein a discharge end of the nozzle is sharpened, and the method further includes piercing the tissue at the surgical site with the discharge end and depositing the biomaterial to create material abutments as a base layer within the tissue.
4. The method of claim 1 , further comprising:
removing the additive manufacturing device from the end effector after printing the tissue engineering construct.
5. The method of claim 4 , further comprising:
after removing the additive manufacturing device, attaching a tool to the end effector; and
inserting the tool into the patient's body.
6. The method of claim 1 , wherein the tissue engineering construct is a three-dimensional object.
7. The method of claim 6 , wherein the three-dimensional object is one of an organ, a bone, a cartilage, a ligament, a tendon, and a muscle.
8. The method of claim 1 , wherein the biomaterial contains cells.
9. The method of claim 1 , wherein the step of commanding the end effector includes moving the nozzle to deposit successive layers of the biomaterial at the surgical site.
10. A method for printing a tissue engineering construct inside a patient's body using a robotic surgical system having an articulating arm and an end effector coupled to a distal end of the articulating arm, the end effector configured to have at least three degrees of movement being controlled by the robotic surgical system, the method comprising:
providing an additive manufacturing device including a first mechanical transmission element engaged with the end effector, a biomaterial reservoir filled with biomaterial and operatively coupled to the first mechanical transmission element, and a nozzle in fluid communication with the biomaterial reservoir;
attaching the additive manufacturing device to the end effector;
inserting the nozzle into the patient's body proximate a surgical site;
commanding the end effector to move the nozzle at the surgical site; and
operating the end effector so as to expel biomaterial out of the nozzle to deposit successive layers of the biomaterial to synthesize a three-dimensional object at the surgical site within the patient's body.
11. The method of claim 10 , wherein the additive manufacturing device further includes:
an articulating joint operatively coupled to the nozzle, the articulating joint has at least one degree of freedom of movement; and
a second mechanical transmission element operatively coupled to the articulating joint and engaged with the end effector, the method further comprising:
commanding the end effector to move the nozzle corresponding to the least one degree of freedom of movement of the articulating joint while depositing the successive layers of the biomaterial at the surgical site.
12. The method of claim 10 , wherein a discharge end of the nozzle is sharpened and the method further includes piercing the tissue at the surgical site with the discharge end and depositing the biomaterial to create material abutments as a base layer within the tissue.
13. The method of claim 10 , further comprising:
removing the additive manufacturing device from the end effector after synthesizing the three-dimensional object.
14. The method of claim 13 , further comprising:
after removing the additive manufacturing device, attaching a tool to the end effector; and
inserting the tool into the patient's body.
15. The method of claim 10 , wherein the three-dimensional object is one of an organ, a bone, a cartilage, a ligament, a tendon, and a muscle.
16. The method of claim 10 , wherein the biomaterial contains cells.