CD73 inhibitors
Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
1. A compound selected from:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition, comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
3. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition, comprising a compound of claim 3 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
5. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
6. A pharmaceutical composition, comprising a compound of claim 5 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
7. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
8. A pharmaceutical composition, comprising a compound of claim 7 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
9. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
10. A pharmaceutical composition, comprising a compound of claim 9 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
11. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
12. A pharmaceutical composition, comprising a compound of claim 11 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
13. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
14. A pharmaceutical composition, comprising a compound of claim 13 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
15. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
16. A pharmaceutical composition, comprising a compound of claim 15 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
17. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
18. A pharmaceutical composition, comprising a compound of claim 17 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
19. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
20. A pharmaceutical composition, comprising a compound of claim 19 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
21. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
22. A pharmaceutical composition, comprising a compound of claim 21 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
23. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
24. A pharmaceutical composition, comprising a compound of claim 23 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
25. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
26. A pharmaceutical composition, comprising a compound of claim 25 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
27. A method of inhibiting CD73 comprising contacting CD73 with a compound of claim 1 , or a pharmaceutically acceptable salt thereof.
28. A method of treating cancer in a subject, comprising administering to the subject a compound of claim 1 , or a pharmaceutically acceptable salt thereof.
29. The method of claim 28 , wherein the cancer is a solid tumor.
30. The method of claim 29 , wherein the solid tumor is lung cancer, melanoma, breast cancer, ovarian cancer, colorectal cancer, gastric cancer, gallbladder cancer, prostate cancer, or renal cancer.