Alpha-5 beta-1 inhibitors

1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof:

wherein:

m is 1 or 2;

A 1 is C(R 4 ) or N;

A 2 is C(R 10 ) or N;

X is a bond, —C(R 15 )(R 16 )— or —N(R 15 )—;

L 1 is bond, —C(O)—, —C(O)O—, —O—, —S—, —NH—, —C(O)NH—, —NHC(O)—, —S(O) 2 —, —S(O)NH—, —(CH 2 ) z1 —NH—, —(CH 2 ) z3 —N((CH 2 ) z4 CH 3 )—C(═O)—, L 11 -substituted or unsubstituted alkylene, unsubstituted heteroalkylene, L 11 -substituted or unsubstituted cycloalkylene, L 11 -substituted or unsubstituted heterocycloalkylene, L 11 -substituted or unsubstituted arylene, or L 11 -substituted or unsubstituted heteroarylene;

L 11 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 1 is hydrogen, R 100 -substituted or unsubstituted alkyl, R 100 -substituted or unsubstituted heteroalkyl, R 100 -substituted or unsubstituted cycloalkyl, or —[P(═O)(OH)O—] n —H, where n is an integer from 1 to 3;

R 100 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 101 -substituted or unsubstituted alkyl, R 101 -substituted or unsubstituted heteroalkyl, R 101 -substituted or unsubstituted cycloalkyl, R 101 -substituted or unsubstituted heterocycloalkyl, R 101 -substituted or unsubstituted aryl, or R 101 -substituted or unsubstituted heteroaryl;

R 101 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 2 is hydrogen, halogen, —CX 2 3 , —CHX 2 2 , —CH 2 X 2 , —OCX 2 3 , —OCH 2 X 2 , —OCHX 2 2 , —SO n2 R 2A , —SO v2 NR 2A R 2B , —CN, —C(O)R 2A , —C(O)OR 2A , —C(O)NR 2A R 2B , —OR 2A , —ONR 2A R 2B , —NHC(O)NR 2A R 2B , —N(O) m2 , —NR 2A R 2B , —NHNR 2A R 2B , —NR 2A SO 2 R 2B , —NR 2A C(O)R 2B , —NR 2A C(O)OR 2B , —NR 2A OR 2B , —N 3 , R 200 -substituted or unsubstituted alkyl, R 200 -substituted or unsubstituted heteroalkyl, R 200 -substituted or unsubstituted cycloalkyl, R 200 -substituted or unsubstituted heterocycloalkyl, R 200 -substituted or unsubstituted aryl, or R 200 -substituted or unsubstituted heteroaryl;

R 2A and R 2B are independently hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 200 -substituted or unsubstituted alkyl, R 200 -substituted or unsubstituted heteroalkyl, R 200 -substituted or unsubstituted cycloalkyl, R 200 -substituted or unsubstituted heterocycloalkyl, R 200 -substituted or unsubstituted aryl, or R 200 -substituted or unsubstituted heteroaryl;

R 200 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 201 -substituted or unsubstituted alkyl, R 201 -substituted or unsubstituted heteroalkyl, R 201 -substituted or unsubstituted cycloalkyl, R 201 -substituted or unsubstituted heterocycloalkyl, R 201 -substituted or unsubstituted aryl, or R 201 -substituted or unsubstituted heteroaryl;

R 201 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 3 is hydrogen, halogen, —CX 3 3 , —CHX 3 2 , —CH 2 X 3 , —OCX 3 3 , —OCH 2 X 3 , —OCHX 3 2 , —SO n3 R 3A , —SO v3 NR 3A R 3B , —CN, —C(O)R 3A , —C(O)OR 3A , —C(O)NR 3A R 3B , —OR 3A , —ONR 3A R 3B , —NHC(O)NR 3A R 3B , —N(O) m3 , —NR 3A R 3B , —NHNR 3A R 3B , —NR 3A SO 2 R 3B , —NR 3A C(O)R 3B , —NR 3A C(O)OR 3B , —NR 3A OR 3B , —N 3 , R 300 -substituted or unsubstituted alkyl, R 300 -substituted or unsubstituted heteroalkyl, R 300 -substituted or unsubstituted cycloalkyl, R 300 -substituted or unsubstituted heterocycloalkyl, R 300 -substituted or unsubstituted aryl, or R 300 -substituted or unsubstituted heteroaryl;

R 3A and R 3B are independently hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 300 -substituted or unsubstituted alkyl, R 300 -substituted or unsubstituted heteroalkyl, R 300 -substituted or unsubstituted cycloalkyl, R 300 -substituted or unsubstituted heterocycloalkyl, R 300 -substituted or unsubstituted aryl, or R 300 -substituted or unsubstituted heteroaryl;

R 300 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 301 -substituted or unsubstituted alkyl, R 301 -substituted or unsubstituted heteroalkyl, R 301 -substituted or unsubstituted cycloalkyl, R 301 -substituted or unsubstituted heterocycloalkyl, R 301 -substituted or unsubstituted aryl, or R 301 -substituted or unsubstituted heteroaryl;

R 301 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 4 is hydrogen, halogen, —CX 4 3 , —CHX 4 2 , —CH 2 X 4 , —OCX 4 3 , —OCH 2 X 4 , —OCHX 4 2 , —SO n4 R 4A , —SO v4 NR 4A R 4B , —CN, —C(O)R 4A , —C(O)OR 4A , —C(O)NR 4A R 4B , —ONR 4A R 4B , —NHC(O)NR 4A R 4B , —N(O) m4 , —NR 4A R 4B , —NHNR 4A R 4B , —NR 4A SO 2 R 4B , —NR 4A C(O)R 4B , —NR 4A C(O)OR 4B , —NR 4A OR 4B , —N 3 , R 400 -substituted or unsubstituted alkyl, R 400 -substituted or unsubstituted cycloalkyl, R 400 -substituted or unsubstituted heterocycloalkyl, R 400 -substituted or unsubstituted aryl, or R 400 -substituted or unsubstituted heteroaryl;

R 4A and R 4B are independently hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 400 -substituted or unsubstituted alkyl, R 400 -substituted or unsubstituted heteroalkyl, R 400 -substituted or unsubstituted cycloalkyl, R 400 -substituted or unsubstituted heterocycloalkyl, R 400 -substituted or unsubstituted aryl, or R 400 -substituted or unsubstituted heteroaryl;

R 400 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 401 -substituted or unsubstituted alkyl, R 401 -substituted or unsubstituted heteroalkyl, R 401 -substituted or unsubstituted cycloalkyl, R 401 -substituted or unsubstituted heterocycloalkyl, R 401 -substituted or unsubstituted aryl, or R 401 -substituted or unsubstituted heteroaryl;

R 401 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 5 is hydrogen, halogen, —CX 5 3 , —CHX 5 2 , —CH 2 X 5 , —OCX 5 3 , —OCH 2 X 5 , —OCHX 5 2 , —SO n5 R 5A , —SO v5 NR 5A R 5B , —CN, —C(O)R 5A , —C(O)OR 5A , —C(O)NR 5A R 5B , —OR 5A , —ONR 5A R 5B , —NHC(O)NR 5A R 5B , —N(O) m5 , —NR 5A R 5B , —NHNR 5A R 5B , —NR 5A SO 2 R 5B , —NR 5A C(O)R 5B , —NR 5A C(O)OR 5B , —NR 5A OR 5B , —N 3 , R 500 -substituted or unsubstituted alkyl, R 500 -substituted or unsubstituted heteroalkyl, R 500 -substituted or unsubstituted cycloalkyl, R 500 -substituted or unsubstituted heterocycloalkyl, R 500 -substituted or unsubstituted aryl, or R 500 -substituted or unsubstituted heteroaryl;

R 5A and R 5B are independently hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 500 -substituted or unsubstituted alkyl, R 500 -substituted or unsubstituted heteroalkyl, R 500 -substituted or unsubstituted cycloalkyl, R 500 -substituted or unsubstituted heterocycloalkyl, R 500 -substituted or unsubstituted aryl, or R 500 -substituted or unsubstituted heteroaryl;

R 500 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 501 -substituted or unsubstituted alkyl, R 501 -substituted or unsubstituted heteroalkyl, R 501 -substituted or unsubstituted cycloalkyl, R 501 -substituted or unsubstituted heterocycloalkyl, R 501 -substituted or unsubstituted aryl, or R 501 -substituted or unsubstituted heteroaryl;

R 501 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 6 is hydrogen, halogen, —CX 6 3 , —CHX 6 2 , —CH 2 X 6 , —OCX 6 3 , —OCH 2 X 6 , —OCHX 6 2 , —SO n6 R 6A , —SO v6 NR 6A R 6B , —CN, —C(O)R 6A , —C(O)OR 6A , —C(O)NR 6A R 6B , —OR 6A , —ONR 6A R 6B , —NHC(O)NR 6A R 6B , —N(O) m6 , —NR 6A R 6B , —NHNR 6A R 6B , —NR 6A SO 2 R 6B , —NR 6A C(O)R 6B , —NR 6A C(O)OR 6B , —NR 6A OR 6B , —N 3 , R 600 -substituted or unsubstituted alkyl, R 600 -substituted or unsubstituted heteroalkyl, R 600 -substituted or unsubstituted cycloalkyl, R 600 -substituted or unsubstituted heterocycloalkyl, R 600 -substituted or unsubstituted aryl, or R 600 -substituted or unsubstituted heteroaryl;

R 6A and R 6B are independently hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 200 -substituted or unsubstituted alkyl, R 600 -substituted or unsubstituted heteroalkyl, R 600 -substituted or unsubstituted cycloalkyl, R 600 -substituted or unsubstituted heterocycloalkyl, R 600 -substituted or unsubstituted aryl, or R 600 -substituted or unsubstituted heteroaryl;

R 600 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 601 -substituted or unsubstituted alkyl, R 601 -substituted or unsubstituted heteroalkyl, R 601 -substituted or unsubstituted cycloalkyl, R 201 -substituted or unsubstituted heterocycloalkyl, R 601 -substituted or unsubstituted aryl, or R 601 -substituted or unsubstituted heteroaryl;

R 601 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 7 is hydrogen, halogen, —CX 7 3 , —CHX 7 2 , —OCX 7 3 , —OCH 2 X 7 , —OCHX 7 2 , —SO n7 R 7A , —SO v7 NR 7A R 7B , —CN, —C(O)R 7A , —C(O)OR 7A , —C(O)NR 7A R 7B , —OR 7A , —ONR 7A R 7B , —NHC(O)NR 7A R 7B , —N(O) m7 , —NR 7A R 7B , —NHNR 7A R 7B , —NR 7A SO 2 R 7B , —NR 7A C(O)R 7B , —NR 7A C(O)OR 7B , —NR 7A OR 7B , —N 3 , R 700 -substituted or unsubstituted alkyl, R 700 -substituted or unsubstituted heteroalkyl, R 700 -substituted or unsubstituted cycloalkyl, R 700 -substituted or unsubstituted heterocycloalkyl, R 700 -substituted or unsubstituted aryl, or R 700 -substituted or unsubstituted heteroaryl;

R 7A and R 7B are independently hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 700 -substituted or unsubstituted alkyl, R 700 -substituted or unsubstituted heteroalkyl, R 700 -substituted or unsubstituted cycloalkyl, R 700 -substituted or unsubstituted heterocycloalkyl, R 700 -substituted or unsubstituted aryl, or R 700 -substituted or unsubstituted heteroaryl;

R 700 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 701 -substituted or unsubstituted alkyl, R 701 -substituted or unsubstituted heteroalkyl, R 701 -substituted or unsubstituted cycloalkyl, R 701 -substituted or unsubstituted heterocycloalkyl, R 701 -substituted or unsubstituted aryl, or R 701 -substituted or unsubstituted heteroaryl;

R 701 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 7 and R 15 are optionally joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein the substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl, or substituted heteroaryl is substituted with a substituent group;

R 8 is hydrogen, halogen, —CX 8 3 , —CHX 8 2 , —CH 2 X 8 , —OCX 8 3 , —OCH 2 X 8 , —OCHX 8 2 , —SO n8 R 8A , —SO v8 NR 8A R 8B , —CN, —C(O)R 8A , —C(O)OR 8A , —C(O)NR 8A R 8B , —OR 8A , —ONR 8A R 8B , —NHC(O)NR 8A R 8B , —N(O) m8 , —NR 8A R 8B , —NHNR 8A R 8B , —NR 8A SO 2 R 8B , —NR 8A C(O)R 8B , —NR 8A C(O)OR 8B , —NR 8A OR 8B , —N 3 , R 800 -substituted or unsubstituted alkyl, R 800 -substituted or unsubstituted heteroalkyl, R 800 -substituted or unsubstituted cycloalkyl, R 800 -substituted or unsubstituted heterocycloalkyl, R 800 -substituted or unsubstituted aryl, or R 800 -substituted or unsubstituted heteroaryl;

R 8A and R 8B are independently hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 800 -substituted or unsubstituted alkyl, R 800 -substituted or unsubstituted heteroalkyl, R 800 -substituted or unsubstituted cycloalkyl, R 800 -substituted or unsubstituted heterocycloalkyl, R 800 -substituted or unsubstituted aryl, or R 800 -substituted or unsubstituted heteroaryl;

R 800 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 801 -substituted or unsubstituted alkyl, R 801 -substituted or unsubstituted heteroalkyl, R 801 -substituted or unsubstituted cycloalkyl, R 801 -substituted or unsubstituted heterocycloalkyl, R 801 -substituted or unsubstituted aryl, or R 801 -substituted or unsubstituted heteroaryl;

R 801 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 9 is hydrogen, halogen, —CX 9 3 , —CHX 9 2 , —CH 2 X 9 , —OCX 9 3 , —OCH 2 X 9 , —OCHX 9 2 , —SO n9 R 9A , —SO v9 NR 9A R 9B , —CN, —C(O)R 9A , —C(O)OR 9A , —C(O)NR 9A R 9B , —OR 9A , —ONR 9A R 9B , —NHC(O)NR 9A R 9B , —N(O) m9 , —NR 9A R 9B , —NHNR 9A R 9B , —NR 9A SO 2 R 9B , —NR 9A C(O)R 9B , —NR 9A C(O)OR 9B , —NR 9A OR 9B , —N 3 , R 900 -substituted or unsubstituted alkyl, R 900 -substituted or unsubstituted heteroalkyl, R 900 -substituted or unsubstituted cycloalkyl, R 900 -substituted or unsubstituted heterocycloalkyl, R 900 -substituted or unsubstituted aryl, or R 900 -substituted or unsubstituted heteroaryl;

R 9A and R 9B are independently hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 900 -substituted or unsubstituted alkyl, R 900 -substituted or unsubstituted heteroalkyl, R 900 -substituted or unsubstituted cycloalkyl, R 900 -substituted or unsubstituted heterocycloalkyl, R 900 -substituted or unsubstituted aryl, or R 900 -substituted or unsubstituted heteroaryl;

R 900 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 901 -substituted or unsubstituted alkyl, R 901 -substituted or unsubstituted heteroalkyl, R 901 -substituted or unsubstituted cycloalkyl, R 901 -substituted or unsubstituted heterocycloalkyl, R 901 -substituted or unsubstituted aryl, or R 901 -substituted or unsubstituted heteroaryl;

R 901 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 9 and R 11 are optionally joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein the substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl, or substituted heteraryl is substituted with a substituent group;

R 10 is hydrogen, halogen, —CX 10 3 , —CHX 10 2 , —CH 2 X 10 , —OCX 10 3 , —OCH 2 X 10 , —OCHX 10 2 , —SO n10 R 10A , —SO v10 NR 10A R 10B , —CN, —C(O)R 10A , —C(O)OR 10A , —C(O)NR 10A R 10B , —OR 10A , —ONR 10A R 10B , —NHC(O)NR 10A R 10B , —N(O) m10 , —NR 10A R 10B , —NHNR 10A R 10B , —NR 10A , —SO 2 R 10B , —NR 10A C(O)R 10B , —NR 10A C(O)OR 10B , —NR 10A OR 10B , —N 3 , R 101′ -substituted or unsubstituted alkyl, R 101′ -substituted or unsubstituted heteroalkyl, R 101′ -substituted or unsubstituted cycloalkyl, R 101′ -substituted or unsubstituted heterocycloalkyl, R 101′ -substituted or unsubstituted aryl, or R 101′ -substituted or unsubstituted heteroaryl;

R 10A and R 10B are independently hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 101′ -substituted or unsubstituted alkyl, R 101′ -substituted or unsubstituted heteroalkyl, R 101′ -substituted or unsubstituted cycloalkyl, R 101′ -substituted or unsubstituted heterocycloalkyl, R 101′ -substituted or unsubstituted aryl, or R 101′ -substituted or unsubstituted heteroaryl;

R 101′ is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 102 -substituted or unsubstituted alkyl, R 102 -substituted or unsubstituted heteroalkyl, R 102 -substituted or unsubstituted cycloalkyl, R 102 -substituted or unsubstituted heterocycloalkyl, R 102 -substituted or unsubstituted aryl, or R 102 -substituted or unsubstituted heteroaryl;

R 102 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 11 is hydrogen, halogen, —CX 11 3 , —CHX 11 2 , —CH 2 X 11 , —OCX 11 3 , —OCH 2 X 11 , —OCHX 11 2 , —SO n11 R 11A , —SO v11 NR 11A R 11B , —CN, —C(O)R 11A , —C(O)OR 11A , —C(O)NR 11A R 11B , —OR 11A , —ONR 11A R 11B , —NHC(O)NR 11A R 11B , —N(O) m11 , —NR 11A R 11B , —NHNR 11A R 11B , —NR 11A SO 2 R 11B , —NR 11A C(O)R 11B , —NR 11A C(O)OR 11B , —NR 11A R 11B , —N 3 , R 110 -substituted or unsubstituted alkyl, R 110 -substituted or unsubstituted heteroalkyl, R 110 -substituted or unsubstituted cycloalkyl, R 110 -substituted or unsubstituted heterocycloalkyl, R 110 -substituted or unsubstituted aryl, or R 110 -substituted or unsubstituted heteroaryl;

R 11A and R 11B are independently hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 110 -substituted or unsubstituted alkyl, R 110 -substituted or unsubstituted heteroalkyl, R 110 -substituted or unsubstituted cycloalkyl, R 110 -substituted or unsubstituted heterocycloalkyl, R 110 -substituted or unsubstituted aryl, or R 110 -substituted or unsubstituted heteroaryl;

R 110 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R ill -substituted or unsubstituted alkyl, R 111 -substituted or unsubstituted heteroalkyl, R 111 -substituted or unsubstituted cycloalkyl, R 111 -substituted or unsubstituted heterocycloalkyl, R 111 -substituted or unsubstituted aryl, or R 111 -substituted or unsubstituted heteroaryl;

R 111 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 12 is hydrogen, halogen, —CX 12 3 , —CHX 12 2 , —CH 2 X 12 , —OCX 12 3 , —OCH 2 X 12 , —OCHX 12 2 , —SO n12 R 12A , —SO v12 NR 12A R 12B , —CN, —C(O)R 12A , —C(O)OR 12A , —C(O)NR 12A R 12B , —NR 12A , —ONR 12A R 12B , —NHC(O)NR 12A R 12B , —N(O) m12 , —NR 12A R 12B , —NHNR 12A R 12B , —NR 12A SO 2 R 12B , —NR 12A C(O)R 12B , —NR 12A C(O)OR 12B , —NR 12A OR 12B , —N 3 , R 120 -substituted or unsubstituted alkyl, R 120 -substituted or unsubstituted heteroalkyl, R 120 -substituted or unsubstituted cycloalkyl, R 120 -substituted or unsubstituted heterocycloalkyl, R 120 -substituted or unsubstituted aryl, or R 120 -substituted or unsubstituted heteroaryl;

R 12A and R 12B are independently hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 120 -substituted or unsubstituted alkyl, R 120 -substituted or unsubstituted heteroalkyl, R 120 -substituted or unsubstituted cycloalkyl, R 120 -substituted or unsubstituted heterocycloalkyl, R 120 -substituted or unsubstituted aryl, or R 120 -substituted or unsubstituted heteroaryl;

R 120 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 121 -substituted or unsubstituted alkyl, R 121 -substituted or unsubstituted heteroalkyl, R 121 -substituted or unsubstituted cycloalkyl, R 121 -substituted or unsubstituted heterocycloalkyl, R 121 -substituted or unsubstituted aryl, or R 121 -substituted or unsubstituted heteroaryl;

R 121 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 15 is hydrogen, —C(O)OR 15A , —C(O)R 15A , —SO 2 R 15A , R 150 -substituted or unsubstituted alkyl, R 150 -substituted or unsubstituted heteroalkyl, R 150 -substituted or unsubstituted cycloalkyl, R 150 -substituted or unsubstituted heterocycloalkyl, R 150 -substituted or unsubstituted aryl, or R 150 -substituted or unsubstituted heteroaryl;

R 15A is hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 150 -substituted or unsubstituted alkyl, R 150 -substituted or unsubstituted heteroalkyl, R 150 -substituted or unsubstituted cycloalkyl, R 150 -substituted or unsubstituted heterocycloalkyl, R 150 -substituted or unsubstituted aryl, or R 150 -substituted or unsubstituted heteroaryl;

R 150 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 151 -substituted or unsubstituted alkyl, R 151 -substituted or unsubstituted heteroalkyl, R 151 -substituted or unsubstituted cycloalkyl, R 151 -substituted or unsubstituted heterocycloalkyl, R 151 -substituted or unsubstituted aryl, or R 151 -substituted or unsubstituted heteroaryl;

R 151 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

R 16 is hydrogen, —C(O)OR 16A , —C(O)R 16A , —SO 2 R 16A , R 160 -substituted or unsubstituted alkyl, R 160 -substituted or unsubstituted heteroalkyl, R 160 -substituted or unsubstituted cycloalkyl, R 160 -substituted or unsubstituted heterocycloalkyl, R 160 -substituted or unsubstituted aryl, or R 160 -substituted or unsubstituted heteroaryl;

R 16A is hydrogen, halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OC HCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , R 160 -substituted or unsubstituted alkyl, R 160 -substituted or unsubstituted heteroalkyl, R 160 -substituted or unsubstituted cycloalkyl, R 160 -substituted or unsubstituted heterocycloalkyl, R 160 -substituted or unsubstituted aryl, or R 160 -substituted or unsubstituted heteroaryl;

R 160 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , R 161 -substituted or unsubstituted alkyl, R 161 -substituted or unsubstituted heteroalkyl, R 161 -substituted or unsubstituted cycloalkyl, R 161 -substituted or unsubstituted heterocycloalkyl, R 161 -substituted or unsubstituted aryl, or R 161 -substituted or unsubstituted heteroaryl;

R 161 is independently halogen, —CF 3 , —CBr 3 , —CCl 3 , —CI 3 , —CHF 2 , —CHBr 2 , —CHCl 2 , —CHI 2 , —CH 2 F, —CH 2 Br, —CH 2 Cl, —CH 2 I, —OCF 3 , —OCBr 3 , —OCCl 3 , —OCI 3 , —OCHF 2 , —OCHBr 2 , —OCHCl 2 , —OCHI 2 , —OCH 2 F, —OCH 2 Br, —OCH 2 Cl, —OCH 2 I, —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —N(O) 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, —N 3 , unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;

X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , X 8 , X 9 , X 10 , X 11 , and X 12 are each independently —F, —Cl, —Br, or —I;

n2, n3 n4, n5, n6, n7, n8, n9, n10, n11, and n12 are independently an integer from 0 to 4;

m2, m3, m4, m5, m6, m7, m8, m9, m10, m11, and m12 are independently 1 or 2;

v2, v3, v4, v5, v6, v7, v8, v9, v10, v11, and v12 are independently 1 or 2;

z1 is an integer from 1 to 10;

z3 is an integer from 1 to 10; and

z4 is an integer from 0 to 9.

2. The compound of claim 1 , wherein A 1 is C(R 4 ), and A 2 is C(R 10 ).

3. The compound of claim 1 , wherein A 1 is N, and A 2 is C(R 10 ) or N.

4. The compound of claim 1 , wherein m is 2.

5. The compound of claim 1 , wherein X is a bond.

6. The compound of claim 1 , wherein L 1 is a bond, —NH—, —(CH 2 ) z1 —NH—, —(CH 2 ) z2 —, or —(CH 2 ) z3 —N((CH 2 ) z4 CH 3 )—C(═O)—, wherein z2 is an integer from 1 to 10.

7. The compound of claim 1 , wherein R 2 is hydrogen, halogen, —CX 2 3 , —CHX 2 2 , —CH 2 X 2 , —OCX 2 3 , —OCH 2 X 2 , —OCHX 2 2 , —SO n2 R 2A , —SO v2 NR 2A R 2B , —CN, —C(O)R 2A , —C(O)OR 2A , —C(O)NR 2A R 2B , —OR 2A , —ONR 2A R 2B , —NHC(O)NR 2A R 2B , —N(O) m2 , —NR 2A R 2B , —NHNR 2A R 2B , —NR 2A R 2B , —NR 2A C(O)R 2B , —NR 2A C(O)OR 2B , —NR 2A OR 2B , —N 3 , R 200 -substituted alkyl, R 200 -substituted or unsubstituted heteroalkyl, R 200 -substituted or unsubstituted cycloalkyl, R 200 -substituted or unsubstituted heterocycloalkyl, R 200 -substituted or unsubstituted aryl, or R 200 -substituted or unsubstituted heteroaryl.

8. The compound of claim 1 , wherein R 2 is halogen, —CX 2 3 , —CHX 2 2 , —CH 2 X 2 , —OCX 2 3 , —OCH 2 X 2 , or —OCHX 2 2 ; R 6 is halogen, —CX 6 3 , —CHX 6 2 , —CH 2 X 6 , —OCX 6 3 , —OCH 2 X 6 , or —OCHX 6 2 ; and X 2 and X 6 are each independently chlorine or fluorine.

9. The compound of claim 1 , wherein R 2 is halogen and R 6 is halogen or unsubstituted C 1-6 alkyl.

10. The compound of claim 1 , wherein R 4 is hydrogen, halogen, R 400 -substituted or unsubstituted alkyl, R 400 -substituted or unsubstituted cycloalkyl, R 400 -substituted or unsubstituted heterocycloalkyl, R 400 -substituted or unsubstituted aryl, or R 400 -substituted or unsubstituted heteroaryl.

11. The compound of claim 1 , wherein R 3 is hydrogen; R 5 is hydrogen; R 7 is hydrogen; R 8 is hydrogen; R 9 is hydrogen; R 10 is hydrogen; R 11 is hydrogen; R 12 is hydrogen; or a combination of any two or more of the foregoing.

12. The compound of claim 1 , wherein R 11 is R 110 -substituted or unsubstituted heteroalkyl,

13. The compound of claim 1 , wherein R 9 and R 11 are joined to form unsubstituted 5-6 membered heterocycloalkyl.

14. The compound of claim 1 , wherein R 7 and R 15 are joined to form unsubstituted 6 membered heterocycloalkyl, wherein the heterocycloalkyl comprises (i) an oxygen atom, (ii) a nitrogen atom, or (iii) an oxygen atom and a nitrogen atom.

15. The compound of claim 1 , wherein R 7 and R 15 are joined to form unsubstituted 6 membered aryl or an unsubstituted 6 membered cycloalkyl.

16. The compound of claim 1 , wherein R 7 and R 15 are joined to form unsubstituted 5 or 6 membered heteroaryl, wherein the heteroaryl comprises 1 or 2 nitrogen atoms.

17. The compound of claim 1 , wherein the compound of Formula (I) is a compound of Formula (JIB) or a pharmaceutically acceptable salt thereof, or a compound of Formula (IIIB) or a pharmaceutically acceptable salt thereof;

18. The compound of claim 1 , wherein the compound of Formula (I) is:

19. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.

20. A method of treating asthma, rheumatoid arthritis, colorectal cancer, liver cancer, prostate cancer, renal cell carcinoma, breast cancer, esophageal cancer, non-small cell lung cancer, osteosarcoma, ovarian cancer, pancreatic cancer, thyroid cancer, melanoma, or rhabdomyosarcoma; or inhibiting angiogenesis in a patient in need thereof, the method comprising administering to the patient an effective amount of the compound of claim 1 .

21. A compound, or a pharmaceutically acceptable salt thereof, having the formula: