IP Library Granted Patent US 12,274,497
Granted Patent B2
US 12,274,497 · App. 17/118,427 · Granted Apr 15, 2025

Multiplexer for laser-driven intravascular lithotripsy device

Inventors: Christopher A. Cook (Laguna Niguel, CA); Gerald D. Bacher (Carlsbad, CA); Eric Schultheis (San Clemente, CA); Mina Mossayebi (Irvine, CA); Wenjie Xie (La Crescenta, CA); Yu Liu (Irvine, CA)
Assignee: BOLT MEDICAL, INC.
A61B18/245G02B6/4214G02B27/283A61B2018/0022
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Quick Facts
Patent No.
US 12,274,497
App. No.
17/118,427
Granted
Apr 15, 2025
Kind
B2
Abstract

A catheter system for treating a vascular lesion within or adjacent to a vessel wall within a body of a patient includes a single light source that generates light energy, a first light guide and a second light guide, and a multiplexer. The first light guide and the second light guide are each configured to selectively receive light energy from the light source. The multiplexer receives the light energy from the light source in the form of a source beam and selectively directs the light energy from the light source in the form of individual guide beams to each of the first light guide and the second light guide.

Claims (27)

1. A catheter system for treating a treatment site within or adjacent to a vessel wall within a body of a patient, the catheter system including a single light source that generates light energy, the catheter system comprising:

a first light guide and a second light guide that are each configured to selectively receive light energy from the light source;

a multiplexer that receives the light energy from the light source in the form of a source beam and selectively directs the light energy from the light source in the form of individual guide beams to each of the first light guide and the second light guide, the multiplexer including (i) a multiplexer base that is fixed in position relative to the first light guide and the second light guide, (ii) a multiplexer stage that is movably supported on the multiplexer base, (iii) a stage mover that is configured to move the multiplexer stage in a single linear degree of freedom relative to the multiplexer base, (iv) a redirector that is mounted on the multiplexer stage, and (v) coupling optics that are mounted on the multiplexer stage;

a catheter shaft;

a balloon that is coupled to the catheter shaft, the balloon including a balloon wall that defines a balloon interior, the balloon being configured to retain a balloon fluid within the balloon interior, the balloon being selectively inflatable with the balloon fluid to expand to an inflated state such that when the balloon is in the inflated state the balloon wall is configured to be positioned adjacent to the treatment site, the first light guide and the second light guide being positioned at least partially within the balloon interior; and

a system controller including a processor that is configured to control operation of the light source to generate a single source beam in the form of pulses of light energy that are directed to the multiplexer;

wherein the source beam being directed toward the multiplexer initially impinges on the redirector, the redirector being configured to redirect the source beam toward the coupling optics, the coupling optics being configured to focus the individual guide beams received from the redirector to each of the first light guide and the second light guide;

wherein movement of the multiplexer stage relative to the multiplexer base results in corresponding movement of the redirector and the coupling optics relative to the first light guide and the second light guide;

wherein the stage mover moves the multiplexer stage to align a first beam path of a first guide beam with the first light guide before the system controller fires the light source to generate the first guide beam that is directed to the first light guide;

wherein the stage mover subsequently moves the multiplexer stage to align a second beam path of a second guide beam with the second light guide before the system controller fires the light source to generate the second guide beam that is directed to the second light guide; and

wherein the first light guide and the second light guide receive the light energy from the light source and guide the light energy from the light source into the balloon interior to generate plasma in the balloon fluid within the balloon interior, the plasma generation causing rapid bubble formation and imparting pressure waves upon the balloon wall adjacent to the treatment site.

2. The catheter system of claim 1 wherein the multiplexer receives the light energy from the light source and simultaneously directs the light energy from the light source in the form of individual guide beams to each of the first light guide and the second light guide.

3. The catheter system of claim 1 wherein the multiplexer receives the light energy from the light source and sequentially directs the light energy from the light source in the form of individual guide beams to each of the first light guide and the second light guide.

4. The catheter system of claim 1 wherein the light source includes a laser.

5. A catheter system for treating a treatment site within or adjacent to a vessel wall within a body of a patient, the catheter system including a single light source that generates light energy, the catheter system comprising:

a first light guide and a second light guide that are each configured to selectively receive light energy from the light source; and

a multiplexer that receives the light energy from the light source in the form of a source beam and selectively directs the light energy from the light source in the form of individual guide beams to each of the first light guide and the second light guide, the multiplexer including (i) an optical element that splits the source beam into a first guide beam and a second guide beam, and (ii) coupling optics that are configured to focus the first guide beam onto the first light guide and the second guide beam onto the second light guide;

wherein the optical element includes an input surface that is partially reflective, a rear surface, and an exit surface that is anti-reflective; and

wherein the source beam impinging on the input surface splits the source beam into the first guide beam that is directed toward the coupling optics, and the second guide beam that is transmitted through the input surface toward the rear surface, reflects off of the rear surface and is directed through the exit surface and toward the coupling optics.

6. The catheter system of claim 5 wherein the optical element is an imperfect parallelogram.

7. The catheter system of claim 1 wherein the balloon includes a drug eluting coating.

8. The catheter system of claim 1 further comprising a power source that is configured to provide power to each of the light source, the system controller and the multiplexer.

9. The catheter system of claim 1 wherein the redirector redirects the source beam by approximately 90 degrees toward the coupling optics.

10. The catheter system of claim 1 further comprising an optical element that is positioned in a beam path of the source beam and that redirects the source beam from the light source so that the source beam is directed toward the multiplexer.

11. The catheter system of claim 10 wherein the optical element redirects the source beam from the light source by approximately 90 degrees so that the source beam is directed toward the multiplexer.

12. The catheter system of claim 5 further comprising a catheter shaft and a balloon that is coupled to the catheter shaft, the balloon including a balloon wall that defines a balloon interior, the balloon being configured to retain a balloon fluid within the balloon interior, the balloon being selectively inflatable with the balloon fluid to expand to an inflated state such that when the balloon is in the inflated state the balloon wall is configured to be positioned adjacent to the treatment site, the first light guide and the second light guide being positioned at least partially within the balloon interior.

13. The catheter system of claim 12 wherein the first light guide and the second light guide receive the light energy from the light source and guide the light energy from the light source into the balloon interior to generate plasma in the balloon fluid within the balloon interior, the plasma generation causing rapid bubble formation and imparting pressure waves upon the balloon wall adjacent to the treatment site.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 27, 2025
From: BOLT MEDICAL, INC.
To: BOSTON SCIENTIFIC SCIMED, INC.
Reel/Frame 073266/0423 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 17, 2021
From: COOK, CHRISTOPHER A.; BACHER, GERALD D.; SCHULTHEIS, ERIC; MOSSAYEBI, MINA; XIE, WENJIE; LIU, YU
To: BOLT MEDICAL, INC.
Reel/Frame 055299/0733 →
Continuity (3)
Provisional Application 63013975 · Apr 22, 2020
Provisional Application 62950014 · Dec 18, 2019
Related Publication 20210186613A1 · Jun 24, 2021
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