IP Library Granted Patent US 11,227,684
Granted Patent B2
US 11,227,684 · App. 17/119,885 · Granted Jan 18, 2022

Systems and methods for processing electronic images for health monitoring and forecasting

Inventors: Christopher Kanan (Rochester, NY); Rodrigo Ceballos Lentini (Long Island City, NY); Jillian Sue (New York, NY); Thomas Fuchs (New York, NY); Leo Grady (New York, NY)
Assignee: Paige.AI, Inc.
G16H30/40G06T7/0012G16H50/20G06T2207/20081G06T2207/20084
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Quick Facts
Patent No.
US 11,227,684
App. No.
17/119,885
Granted
Jan 18, 2022
Kind
B2
Abstract

Systems and methods are disclosed for determining at least one geographic region of a plurality of geographic regions, at least one data variable, and/or at least one health variable, estimating a current prevalence of a data variable in a geographic region of the plurality of geographic regions, determining a trend in a relationship between the data variable and the geographic region at a current time, determining a second trend in the relationship between the data variable and the geographic region at at least one prior point in time, determining if the trend in the relationship is irregular within a predetermined threshold with respect to the second trend from the at least one prior point in time, and, upon determining that the trend in the relationship is irregular within a predetermined threshold, generating an alert.

Claims (59)

1. A computer-implemented method for monitoring health of a patient population, the method comprising:

determining, based on time-stamped patient data of the patient population, a relationship between at least one geographic region of a plurality of geographic regions associated with the patient population, at least one data variable, and at least one health variable of patients of the patient population;

estimating a current prevalence of a data variable in the at least one geographic region of the plurality of geographic regions;

determining a first trend in the relationship between the data variable and the geographic region at a current time;

determining a second trend in the relationship of the first trend between the data variable and the geographic region at at least one prior point in time;

determining if the first trend in the relationship is irregular within a predetermined threshold with respect to the second trend from the at least one prior point in time, the predetermined threshold being identified using a deep learning out-of-distribution technique, and the first trend being irregular as determined between at least one of a geographic region and a demographic variable, a geographic region and a health variable, and a data variable and a health variable within a geographic region; and

upon determining that the first trend in the relationship is irregular within the predetermined threshold, generating an alert related to the patient population.

2. The computer-implemented method of claim 1 , further comprising:

receiving the time-stamped patient data from at least one of one or more physician servers, hospital servers, clinical trial servers, research lab servers, and/or laboratory information systems;

generating an updated relationship between the at least one geographic region, the at least one data variable, and the at least one health variable based on the determined relationship, comprising:

providing the at least one relationship to a machine learning model;

applying the machine learning model to predict at least one future relationship over a time period in the at least one geographic region; and

generating the updated relationship between the at least one geographic region, the at least one data variable, and the at least one health variable based on the at least one future relationship.

3. The computer-implemented method of claim 2 , wherein the machine learning model comprises:

a convolutional neural network; a graph convolutional network; an autoregressive model; a recurrent neural network; and/or a capsule network.

4. The computer-implemented method of claim 2 , wherein applying the machine learning model to predict at least one future relationship over time period in the at least one geographic region comprises:

inferring health related variables from the time-stamped patient data; and

determining disease states and applying at least one natural language processing model to at least one clinic note to extract at least one relevant variable.

5. The computer-implemented method of claim 1 , wherein the time-stamped patient data comprises at least one of a plurality of digital images of pathology specimens, genetic data, pathogenic data, and clinical notes.

6. The computer-implemented method of claim 4 , further comprising:

storing the time-stamped patient data into a digital storage device.

7. The computer-implemented method of claim 2 , wherein applying a machine learning model to predict at least one future relationship over time in the at least one geographic region comprises using at least one of: a convolutional neural network; a graph convolution network; an autoregressive model; a recurrent neural network; and a capsule network.

8. The computer-implemented method of claim 1 , wherein determining the at least one relationship between the at least one geographic region, at least one data variable, or at least one health variable comprises using correlation machine learning and/or geographic visual overlay.

9. The computer-implemented method of claim 1 , wherein a query is received from a user for one of a particular health variable, a particular data variable.

10. The computer-implemented method of claim 1 , wherein a trend is irregular if a variable mismatch is identified or if a sudden increase or a sudden decrease of a trend is detected.

11. A system for monitoring health of a patient population, the system comprising:

at least one memory storing instructions; and

at least one processor configured to execute the instructions to perform operations comprising:

receiving a query for a particular health variable, a data variable, and a geographic region;

estimating a current prevalence of a data variable in a geographic region;

determining a first trend in a relationship of the patient population at a current time;

determining a second trend in the relationship of the first trend between the data variable and the geographic region at at least one prior point in time;

generating an alert, related to the patient population, if the first trend in the relationship is irregular within a predetermined threshold with respect to the second trend from the at least one prior point in time, the predetermined threshold being identified using a deep learning out-of-distribution technique, and the trend being irregular as determined between at least one of a geographic region and a demographic variable, a geographic region and a health variable, and a data variable and a health variable within a geographic region;

training a machine learning model to predict future relationships over time in a geographic region; and

determining, based on the predicted future relationships, whether to continue monitoring health of the patient population.

12. The system of claim 11 , the operations further comprising:

generating an updated relationship between the at least one geographic region, the at least one data variable, and the at least one health variable based on the relationship, comprising:

providing the at updated relationship to a machine learning model;

applying the machine learning model to predict at least one future relationship over a time period in the at least one geographic region; and

generating the updated relationship between the at least one geographic region, the at least one data variable, and the at least one health variable based on the at least one future relationship.

13. The system of claim 12 , wherein the machine learning model comprises:

a convolutional neural network; a graph convolutional network, an autoregressive model, a recurrent neural network, and/or a capsule network.

14. The system of claim 12 , wherein applying the machine learning model to predict the at least one future relationship over the time period in the at least one geographic region comprises:

inferring health related variables from a time-stamped patient data; and

determining disease states and applying at least one natural language processing model to at least one clinic note to extract at least one relevant variable.

15. The system of claim 14 , wherein the time-stamped patient data comprises at least one of digital images of pathology specimens, genetic data, pathogenic data, and/or clinical notes.

16. The system of claim 14 , the operations further comprising:

storing the time-stamped patient data into a digital storage device.

17. The system of claim 12 , wherein applying a machine learning model to predict at least one future relationship over time in the at least one geographic region comprises using at least one of: a convolutional neural network; a graph convolution network; an autoregressive model; a recurrent neural network; and a capsule network.

18. The system of claim 11 , wherein determining the relationship between the at least one geographic region, at least one data variable, at least one health variable comprises using correlation machine learning and/or geographic visual overlay.

19. The system of claim 11 , wherein a query is received from a user for one of a particular health variable, a particular data variable.

20. A non-transitory computer readable medium storing instructions that, when executed by a processor, cause the processor to perform a method for monitoring health of a patient population, the method comprising:

receiving a query for a particular health variable, a data variable, and/or a geographic region;

estimating a current prevalence of a data variable in a geographic region of the patient population;

determining, based on time-stamped patient data of the patient population, a first trend in a relationship between at least one geographic region(s), at least one data variable(s), and at least one health variable(s);

determining a second trend in the relationship of the first trend between the data variable and the geographic region at at least one prior point in time;

generating an alert if the second trend is irregular within a predetermined threshold with respect to the second trend from the at least one prior point in time, the predetermined threshold being identified using a deep learning out-of-distribution technique, and the first trend being irregular as determined between at least one of a geographic region and a demographic variable, a geographic region and a health variable, and a data variable and a health variable within a geographic region;

training a machine learning model to predict future relationships related to the patient population over time in the geographic region; and

determining, based on the predicted future relationships, whether to continue monitoring health of the patient population.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded May 14, 2026
From: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
To: PAIGE.AI, INC.
Reel/Frame 075589/0752 →
SECURITY INTEREST Recorded Oct 21, 2025
From: PAIGE.AI, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 073216/0876 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 22, 2020
From: KANAN, CHRISTOPHER; CEBALLOS LENTINI, RODRIGO; SUE, JILLIAN; FUCHS, THOMAS; GRADY, LEO
To: PAIGE.AI, INC.
Reel/Frame 054734/0174 →
Continuity (3)
Continuation 17107121 · Nov 30, 2020
Provisional Application 62951491 · Dec 20, 2019
Related Publication 20210193301A1 · Jun 24, 2021
Cited By (1)
US 12,700,098