MODULATION OF TISSUE FATTY ACID COMPOSITION OF A HOST BY HUMAN GUT BACTERIA
The current invention provides use of a CLA-producing bacterium for the in vivo conversion in the gut of polyunsaturated fatty acids to CLA. The CLA-producing bacterium is selected from one or more of the group consisting of propionibacteria, lactobacilli, lactococci and streptococci, and bifidobacteria.
1 - 25 . (canceled)
26 . A method for altering a fatty acid composition of an internal organ of a body of a subject, the method comprising administering to the subject a product comprising Bifidobacterium breve as deposited at the National Culture of Industrial and Marine Bacteria under accession no. 702258 or a rifampicin resistant variant thereof.
27 . The method of claim 26 , wherein the organ is a liver of the subject.
28 . The method of claim 26 , wherein the organ is a brain of the subject.
29 . The method of claim 26 , wherein the product further comprises a pharmaceutically acceptable additive.
30 . The method of claim 26 , wherein the product further comprises a nutritionally acceptable additive.
31 . The method of claim 26 , wherein the product is a foodstuff selected from a yogurt, a yogurt drink, a cheese, a milk, a spread, a fruit juice, flavoured water, or unflavoured water.
32 . The method of claim 26 , wherein the product further comprises a substrate capable of being converted into a bioactive compound in vivo by the bacterium.
33 . The method of claim 32 , wherein the substrate is a polyunsaturated fatty acid.
34 . The method of claim 33 , wherein the polyunsaturated fatty acid is linoleic acid, linolenic acid, oleic acid, palmitic acid, or stearic acid.
35 . A composition comprising Bifidobacterium breve as deposited at the National Culture of Industrial and Marine Bacteria under accession no. 702258 or a rifampicin resistant variant thereof, and an additive.
36 . The composition of claim 35 , wherein the additive is a nutritionally acceptable additive.
37 . The composition of claim 35 , further comprising a substrate capable of being converted into a bioactive compound in vivo by the bacterium.
38 . A foodstuff comprising the composition of claim 37 , wherein the substrate is a polyunsaturated fatty acid.
39 . The foodstuff of claim 38 , wherein the polyunsaturated fatty acid is linoleic acid, linolenic acid, oleic acid, palmitic acid, or stearic acid.