IP Library › Granted Patent US 12,245,956
Granted Patent B2
US 12,245,956 · App. 17/120,938 · Granted Mar 11, 2025

Peripheral neural interface via nerve regeneration to distal tissues

Inventors: Hugh M. Herr (Concord, NH); Ronald R. Riso (Carlisle, MA); Katherine W. Song (Sunnyvale, CA); Richard J. Casler, Jr. (Los Gatos, CA); Matthew J. Carty (Somerville, MA)
Assignee: Massachusetts Institute of Technology
A61F2/72A61F2/68A61N1/0551A61N1/36003A61B5/0028A61B5/0031A61B5/24A61B5/389A61B5/40A61B5/4029A61B5/4041A61B5/4047A61B5/4052A61B5/441A61B5/45A61B5/48A61B5/4824A61B5/4827A61B5/4851A61B5/68A61B5/6801A61B5/6846A61B17/1128A61B2017/1135A61F2/482A61F2002/607A61F2002/6827A61F2002/6872
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Quick Facts
Patent No.
US 12,245,956
App. No.
17/120,938
Granted
Mar 11, 2025
Kind
B2
Abstract

At least partial function of a human limb is restored by surgically removing at least a portion of an injured or diseased human limb from a surgical site of an individual and transplanting a selected muscle into the remaining biological body of the individual, followed by contacting the transplanted selected muscle, or an associated nerve, with an electrode, to thereby control a device, such as a prosthetic limb, linked to the electrode. Simulating proprioceptive sensory feedback from a device includes mechanically linking at least one pair of agonist and antagonist muscles, wherein a nerve innervates each muscle, and supporting each pair with a support, whereby contraction of the agonist muscle of each pair will cause extension of the paired antagonist muscle. An electrode is implanted in a muscle of each pair and electrically connected to a motor controller of the device, thereby simulating proprioceptive sensory feedback from the device.

Claims (30)

1. A prosthesis, orthosis or exoskeleton device for restoring lost functionality to a subject, comprising:

an implanted sensing system configured to measure muscle-tendon signals of at least one agonist-antagonist muscle-tendon pair of the subject, the pair comprising an agonist muscle-tendon connected to an antagonist muscle-tendon, the muscle-tendon signals being representative of agonist-antagonist muscle-tendon dynamics, the muscle-tendon signals comprising at least one of a muscle length, a muscle velocity, or a muscle force in at least one muscle-tendon of the agonist-antagonist muscle-tendon pair;

a support configured to support the at least one agonist-antagonist muscle-tendon pair, whereby contraction of one muscle-tendon of the at least one pair will cause extension of the paired muscle-tendon; and

a controller configured to:

map the muscle-tendon signals to a control target comprising at least one of a joint torque, a joint impedance, or a joint state, the joint impedance comprising at least one of a joint stiffness or a damping, the joint state comprising at least one of a joint angle or an angular rate; and

output the control target to command a powered actuator of the prosthesis, orthosis, or exoskeleton device, thereby at least partially restoring the lost functionality to the subject.

2. The device of claim 1 , wherein the muscle-tendon signals include the muscle length and the muscle velocity.

3. The device of claim 1 , wherein the muscle-tendon signals include the muscle force.

4. The device of claim 1 , wherein the implanted sensing system includes at least one of a position sensor or a force sensor implanted at the muscle.

5. The device of claim 4 , wherein the implanted sensing system comprises a position sensor and wherein the position sensor includes a plurality of implanted piezoelectric crystals.

6. The device of claim 5 , wherein the piezoelectric crystals include sonomicrometry crystals.

7. The device of claim 6 , wherein the implanted piezoelectric crystals are each configured to define a position relative to at least one other of the implanted piezoelectric crystals, and wherein the controller maps the relative positions of the crystals to the control target.

8. The device of claim 7 , wherein the implanted sensing system comprises a force sensor, and wherein estimating the joint state further includes measuring with the force sensor the force applied by the muscle, and combining that measurement with the measurement of at least one of speed or length of the muscle.

9. The device of claim 8 , wherein the force sensor includes at least one of a strain gauge or a force buckle.

10. The device of claim 4 , wherein the controller maps at least one of i) force estimated using measurement of at least one of length or speed of the muscle measured with the position sensor, or ii) force measured with the force sensor, to the control target.

11. The device of claim 10 , wherein the controller maps to the control target a muscle model estimate of the tendon force using the measurement of the at least one of length or speed of the muscle and an electromyographic signal strength measured at the muscle.

12. The device of claim 11 , further comprising an electrode implanted at the biological muscle, the electromyographic signal strength being measured with the electrode.

13. The device of claim 12 , wherein the electrode is implanted on an epimysium of the muscle or intramuscularly in the muscle.

14. The device of claim 1 , wherein the controller is configured to receive joint position or joint torque signals from the prosthesis, orthosis or exoskeleton device, and to map the signals to a functional electrical stimulation channel that stimulates at least one muscle of the agonist and antagonist muscle pair via an associated pair of electrodes, delivering proprioceptive feedback to the subject wearing the device.

15. The device of claim 14 , wherein the controller employs a biomimetic model of the limb to map measured joint torque of the prosthesis, orthosis or exoskeleton device to corresponding muscle-tendon forces of the agonist and antagonist muscle pair, and wherein the controller is configured to selectively stimulate the at least one muscle of the agonist and antagonist muscle pair that is associated with joint torque in the same direction as the measured joint torque, thereby modulating force on other muscle of the agonist and antagonist muscle pair.

16. The device of claim 1 , wherein the controller employs a biomimetic model of the limb to map the measured muscle state of at least one muscle of the agonist and antagonist muscle pair and an electromyographic signal strength measured at the at least one muscle to a corresponding joint state and joint torque of the device.

17. The device of claim 1 , further comprising a sensory controller that maps detection of at least one of stress, strain, contact, pressure, force, or shear applied at the device into electrical stimulation of an actuator muscle coupled to and exerting forces on a skin patch of the subject, to provide the subject with cutaneous sensory feedback from the device.

18. The device of claim 1 ,

further comprising a pair of electrodes, one electrode of the pair of electrodes operatively connected to the agonist muscle or an agonist nerve and the other electrode of the pair of electrodes operatively connected to the antagonist muscle or an antagonist nerve of the at least one agonist-antagonist muscle-tendon pair, and

the controller further comprising at least one pair of functional-electrical stimulation (FES) channels, the pair of FES channels operatively connected to the electrodes and mapped to a prosthetic joint state or torque associated with the agonist-antagonist muscle-tendon pair; the controller configured to apply simulation via the FES channels to control at least one of muscle-tendon force or muscle-tendon position so as to provide proprioceptive feedback to the subject that is representative of feedback applied in an intact limb prior to amputation from the same loading conditions.

19. The device of claim 1 , wherein the controller applies closed-loop control of an actuator of the prosthesis, orthosis or exoskeleton device, the actuator servoing to the control target, thereby at least partially restoring the lost functionality to the subject.

20. The device of claim 1 , wherein the sensing system comprises a plurality of position sensors implanted in the at least one muscle-tendon of the agonist-antagonist muscle-tendon pair; and, the relative positions of the plurality of position sensors is used to measure muscle contraction or elongation, the muscle contraction or elongation is then used to estimate at least one of muscle length, muscle velocity, or muscle force, the at least one of muscle length, muscle velocity, or muscle force is used to map to the control target.

21. The device of claim 1 , wherein the support comprises synthetic material.

22. The device of claim 1 , wherein the support comprises biologic material.

23. The device of claim 1 , wherein the support is configured to support the at least one agonist-antagonist muscle-tendon pair at opposite ends of the support.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 28, 2020
From: HERR, HUGH M.; RISO, RONALD R.; SONG, KATHERINE W.; CASLER, RICHARD J., JR.; CARTY, MATTHEW J.
To: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Reel/Frame 054752/0237 →
Continuity (5)
Continuation 15233241 · Aug 10, 2016
Division 14520766 · Oct 22, 2014
Provisional Application 62019266 · Jun 30, 2014
Provisional Application 61894040 · Oct 22, 2013
Related Publication 20210093470A1 · Apr 1, 2021
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