Bone repair composition and kit
A biocompatible material for bone repair is described. The bone repair composition includes a mixture of a type I collagen, a type I collagen-glycosaminoglycan coprecipitate, tricalcium phosphate; and bioactive glass. Methods of using the composition for bone repair, and a kit for the bone repair composition are also described.
1. A bone repair composition, comprising
a particulate dispersion comprising a strip product and comprising a collagen component, a bone growth stimulator, and a bioactive glass,
wherein
the bioactive glass ranges from 15% to 25% by weight of the particulate dispersion and comprises bioactive glass particles having a size from 250 to 2000 microns,
the bone growth stimulator comprising calcium phosphate ranges from 75% to 85% by weight of the particulate dispersion and comprises bone growth stimulator particles having a size from 250 to 2500 microns,
the collagen component ranges from 0.5% to 10% by weight of the particulate dispersion, and
the strip product contains no hydroxyapatite in its formulation.
2. The composition of claim 1 , wherein the bone growth stimulator particles have a size from 400 to 1600 microns.
3. The composition of claim 1 , wherein the bioactive glass particles have a size from 250 to 1500 microns.
4. The composition of claim 1 , wherein the bioactive glass develops a hydroxyapatite surface layer upon implantation within a subject.
5. The composition of claim 1 , wherein the particulate dispersion is configured as a rectangular strip.
6. The composition of claim 1 , wherein the collagen component is blended into an aqueous dispersion before incorporation into the particulate dispersion.
7. The composition of claim 6 , wherein the particulate dispersion comprises a cross-linked dispersion formed from the aqueous dispersion of the collagen compound.
8. The composition of claim 7 , wherein the cross-linked dispersion is formed from the aqueous dispersion mixed with the bioactive glass and the bone growth stimulator, freeze-dried, and then cross-linked.
9. The composition of claim 1 , wherein the collagen compound comprises a type I collagen.
10. The composition of claim 9 , wherein the collagen compound further comprises a type I collagen-glycosaminoglycan coprecipitate.
11. A method of repairing a bone defect, comprising administering a composition according to claim 1 to the site of the bone defect.
12. The method of claim 11 , wherein the composition is hydrated before administering the bone repair composition to the site of the bone defect.
13. The method of claim 11 , wherein the bone repair composition is hydrated with autologous blood.
14. The method of claim 11 , wherein the bone defect is, or is the result, a simple fracture, a compound fracture, external fixation, internal fixation, joint reconstruction, arthroplasty, degenerative disc disease, avascular osteonecrosis, osteosarcoma fracture, fracture non-unions, spinal fusion, disc augmentation, or bone regeneration in orthopedic implants.
15. A bone repair kit, comprising:
the bone repair composition of claim 1 ; and
a packaging including a tray for holding the bone repair composition,
wherein
the tray includes a support region having a raised surface above a bottom of the tray, and
the raised surface holds the bone repair composition above the bottom of the tray.
16. The bone repair kit of claim 15 , wherein the bone repair composition is configured as a rectangular strip.
17. The bone repair kit of claim 15 , wherein the tray is configured to fit the shape of the bone repair composition.
18. The bone repair kit of claim 17 , wherein the tray includes one or more grip regions to facilitate access to the bone repair composition.
19. The bone repair kit of claim 15 , wherein the kit includes a cover that can be sealed with a sheet to hold the tray.
20. The bone repair kit of claim 15 , wherein the package comprises high density polyethylene.
21. A bone repair composition, comprising
a particulate dispersion comprising a strip product and comprising a collagen component, a bone growth stimulator, and a bioactive glass,
wherein
the bioactive glass ranges from 15% to 25% by weight of the particulate dispersion and comprises bioactive glass particles having a size from 250 to 2000 microns,
the bone growth stimulator ranges from 75% to 85% by weight of the particulate dispersion and comprises bone growth stimulator particles having a size from 250 to 2500 microns,
the collagen component ranges from 0.5% to 10% by weight of the particulate dispersion and comprises particles or flakes which are milled to pass through a 2000 micron mesh, and
the strip product contains no hydroxyapatite in its formulation.