Pressurized goggle for intraocular pressure modification
Assemblies and methods for modifying an intraocular pressure of a patient's one or both eyes are disclosed. The assemblies and methods can be used to treat, inhibit, or prevent ocular conditions such as glaucoma, high intraocular pressure, optic disc edema, idiopathic intracranial hypertension, zero-gravity induced papilledema, and other optic pressure related conditions. An assembly can include a goggle including at least one cavity, a pump in fluid communication with the at least one cavity, and a control mechanism. The control mechanism can be operatively coupled to the pump and can maintain a target pressure or target pressure range in the at least one cavity, which, when the assembly is worn by a patient, is the area between a patient's eye(s) and wall surfaces of the goggle. Controlling the pressure over the outer surfaces of the patient's eye(s) can drive a desired change in the intraocular pressure of the eye(s).
1. A method to treat an eye condition in a patient eye with an assembly, the assembly including a pressure source configured to adjust fluid pressure in a cavity formed by an enclosure located over the patient eye, the method comprising:
forming the cavity over the patient eye with the enclosure, wherein the enclosure does not contact the patient eye;
monitoring, using biosensors, an indication of intraocular pressure (IOP) and an indication of cerebrospinal fluid pressure (CSFP) to determine a translaminar pressure gradient (TPG) associated with the patient eye; and
using the determined TPG, controlling the pressure source and adjusting cavity fluid pressure in the cavity to equalize the determined TPG associated with the patient eye for at least a duration sufficient to treat the eye condition by at least temporarily resuming axonal transport across the lamina cribrosa of the patient eye.
2. The method of claim 1 , wherein the determined TPG is a real time TPG determined from a monitored indication of real time IOP and real time CSFP.
3. The method of claim 1 , wherein adjusting cavity fluid pressure includes adjusting cavity fluid pressure in a range of less than 0 mmHg gauge to about −40 mmHg gauge.
4. The method of claim 1 , wherein adjusting cavity fluid pressure includes adjusting cavity fluid pressure in a range of about −5 mmHg gauge to about −20 mmHg gauge.
5. The method of claim 1 , wherein adjusting cavity fluid pressure includes varying fluid pressure over time.
6. The method of claim 5 , wherein varying fluid pressure includes varying fluid pressure as a diurnal cycle.
7. The method of claim 5 , wherein varying fluid pressure includes varying fluid pressure to increase the flow of an eye fluid through at least one of a trabecular meshwork in the patient eye or an anterior ciliary vein of the patient eye.
8. The method of claim 1 , wherein adjusting cavity fluid pressure includes adjusting a set point pressure level.
9. The method of claim 8 , wherein adjusting the set point pressure level includes adjusting the set point pressure level based at least in part on an indication of a physiological parameter associated with the patient eye.
10. The method of claim 9 , wherein adjusting the set point pressure level includes adjusting the set point pressure level to bring the indication of intraocular pressure (IOP) in the patient eye into a range of about 10 mmHg to about 21 mmHg.
11. The method of claim 9 , wherein adjusting the set point pressure level includes adjusting the set point pressure level based at least in part on at least one of the indication of IOP or the indication of CSFP.
12. The method of claim 11 , wherein adjusting the set point pressure level includes adjusting based at least in part on the indication of IOP.
13. The method of claim 11 , wherein adjusting the set point pressure level includes adjusting based at least in part on the indication of CSFP.
14. The method of claim 1 , wherein adjusting cavity fluid pressure includes adjusting cavity fluid pressure in a range of more than 0 mmHg gauge to about 40 mmHg gauge.