Use of riluzole prodrugs to treat Alzheimer's disease
Disclosed are methods of treating Alzheimer's Disease by administering to a patient in need thereof a riluzole prodrug such as troriluzole. Pharmaceutical compositions and kits including the riluzole prodrugs are also disclosed.
1. A method of treating Alzheimer's Disease of mild to moderate severity in a patient in need thereof, the method comprising administering to the patient a riluzole prodrug having the following formula:
wherein the riluzole prodrug is administered to the patient at a dosage of 280 mg once per day or a dosage of 140 mg twice per day.
2. The method of claim 1 , wherein the riluzole prodrug is administered to the patient in the form of a capsule.
3. The method of claim 1 , wherein the riluzole prodrug is administered to the patient for a duration of from the onset of treatment to the end of the patient's life.
4. A method for improving a response in a patient afflicted with Alzheimer's disease of mild to moderate severity, the method comprising administering to the patient in need thereof, an effective amount of a riluzole prodrug having the following formula:
wherein the riluzole prodrug is administered to the patient at a dosage of 280 mg once per day or at a dosage of 140 mg twice per day.
5. The method of claim 4 , wherein the improved response is one or more of overall survival, quality of life, overall response rate, duration of response, delay of onset, or patient reported outcome.
6. A kit for treating a patient afflicted with Alzheimer's Disease of mild to moderate severity, the kit comprising:
(a) a riluzole prodrug; and
(b) instructions for administering the riluzole prodrug in the method of claim 1 ,
wherein the riluzole prodrug has the following formula:
wherein a daily dosage of the riluzole prodrug in the kits is 280 mg.
7. A kit for improving a response in a patient afflicted with Alzheimer's Disease of mild to moderate severity, the kit comprising:
(a) a riluzole prodrug; and
(b) instructions for administering the riluzole prodrug in the method of claim 4 ,
wherein the riluzole prodrug has the following formula:
wherein a daily dosage of the riluzole prodrug in the kit is 280 mg.