Granted Patent
B2
US 12,246,058 · App. 17/153,165 · Granted Mar 11, 2025
Methods and compositions for treating pain
Assignee:
Creighton University
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Abstract
The disclosure provides polypeptides and pharmaceutical compositions thereof. Such polypeptides can be useful, for example, in treating pain in a subject. In some embodiments, the polypeptides are useful for treating neuropathic and/or inflammatory pain.
Claims (13)
1. A method of treating pain in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a polypeptide having the amino acid sequence shown in to SEQ ID NO: 2, or a pharmaceutical composition thereof.
2. The method of claim 1 , wherein administration of the polypeptide or a pharmaceutical composition thereof increases glutamate delta 1 receptor (GluD1)-cerebellin 1 (Cbln1) signaling.
3. A method of increasing GluD1-Cbln1 signaling in a subject in need thereof, the method comprising administering to the subject a polypeptide having the amino acid sequence shown in SEQ ID NO:2, or a pharmaceutical composition thereof.
4. The method of claim 1 , wherein the pain comprises neuropathic pain.
5. The method of claim 4 , wherein the neuropathic pain is associated with nerve compression, nerve damage, abnormal processing of pain signals, or a combination thereof.
6. The method of claim 4 , wherein the neuropathic pain is a side effect of a therapeutic agent.
7. The method of claim 6 , wherein the therapeutic agent is a chemotherapy.
8. The method of claim 7 , wherein the chemotherapy comprises a taxane, a platinum-based agent, a vinca alkaloid, an epothilone, eribulin, bortezomib, thalidomide, or a combination thereof.
9. The method of claim 1 , wherein the subject has chemotherapy-induced neuropathic pain.
10. The method of claim 1 , wherein the pain comprises inflammatory pain.
11. The method of claim 10 , wherein the inflammatory pain is associated with surgery, trauma, arthritis, or a combination thereof.
12. The method of claim 1 , wherein the polypeptide or a pharmaceutical composition thereof is administered to the central nervous system of the subject.
13. A method of reducing an amount of opioid administered to a subject, the method comprising administering to the subject a therapeutically effective amount of a polypeptide having the amino acid sequence shown in SEQ ID NO: 2, or a pharmaceutical composition thereof.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Nov 2, 2023
From: CREIGHTON UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065431/0065 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 26, 2021
From: DRAVID, SHASHANK
To: CREIGHTON UNIVERSITY
Reel/Frame 056042/0837 →
Continuity (2)
Provisional Application
62963253
· Jan 20, 2020
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