Next generation FKBP52 targeting drugs for the treatment of prostate and breast cancer
View Patent ↗Procedures for inhibiting hormone receptor activation include administering to a subject in need of hormone receptor inhibition a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions. Procedures for treating prostate cancer or breast cancer include administering to a subject having prostate cancer or breast cancer a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions.
1. A method of inhibiting hormone receptor activation, comprising administering to a subject in need of hormone receptor inhibition a compound having a chemical structure of Formula I
2. The method of claim 1 , wherein the hormone receptor is the androgen receptor.
3. The method of claim 1 , wherein the subject has hyperplasia or neoplasia.
4. The method of claim 1 , wherein the subject has prostate cancer or breast cancer.
5. The method of claim 1 , further comprising administering chemotherapy or radiation treatments.
6. A method of treating prostate cancer or breast cancer comprising administering to a subject having prostate cancer or breast cancer a compound having a chemical structure of Formula I
7. The method of claim 5 , further comprising administering chemotherapy or radiation treatments.
8. A method of inhibiting hormone receptor activation, comprising
administering to a subject in need of hormone receptor inhibition a compound having a chemical structure of Formula I
and
administering chemotherapy treatment.
9. The method of claim 8 , wherein the hormone receptor is the androgen receptor.
10. The method of claim 8 , wherein the subject has hyperplasia.
11. The method of claim 8 , wherein the subject has neoplasia.
12. The method of claim 8 , wherein the subject has prostate cancer.
13. The method of claim 8 , wherein the subject has breast cancer.
14. A method of inhibiting hormone receptor activation, comprising
administering to a subject in need of hormone receptor inhibition a compound having a chemical structure of Formula I
and
administering radiation treatment.
15. The method of claim 14 , wherein the hormone receptor is the androgen receptor.
16. The method of claim 14 , wherein the subject has hyperplasia.
17. The method of claim 14 , wherein the subject has neoplasia.
18. The method of claim 14 , wherein the subject has prostate cancer.
19. The method of claim 14 , wherein the subject has breast cancer.
20. A method of treating prostate cancer or breast cancer comprising
administering to a subject having prostate cancer or breast cancer a compound having a chemical structure of Formula I
and
administering chemotherapy treatment.
21. A method of treating prostate cancer or breast cancer comprising
administering to a subject having prostate cancer or breast cancer a compound having a chemical structure of Formula I
and
administering radiation treatment.