Compositions and methods for inhibiting arginase activity
The disclosure relates to a novel class of compounds that exhibit activity inhibitory activity toward arginase, and pharmaceutical compositions comprising the compounds of the disclosure. Also provided herein are methods of treating cancer with the arginase inhibitors of the disclosure.
1. A compound having the following structure:
or a pharmaceutically acceptable salt thereof.
2. A compound having the following structure:
or a pharmaceutically acceptable salt thereof.
3. A compound having the following structure:
or a pharmaceutically acceptable salt thereof.
4. A method of treating cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 1 .
5. A method of treating cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 2 .
6. A method of treating cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 3 .