IP Library › Patent Application 17155371
Patent Application
App. No. 17/155,371

COMT Inhibiting Methods and Compositions

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Quick Facts
Patent No.
US None
App. No.
17/155,371
Abstract

This invention relates to compounds, pharmaceutical compositions and their use for treating neuropsychiatric and neurodegenerative disorders. In particular, the invention relates to inhibitors of catechol-O-methyltransferase and their use as therapeutics for central nervous system disease.

Claims (11)

1 . A compound of formula I, or a pharmaceutically acceptable salt thereof:

wherein:

X is selected from hydrogen; chloro; bromo, iodo and cyclopropyl;

Z is selected from hydrogen and fluoro;

R 1 and R 2 are each independently selected from hydrogen; C 1-4 alkyl; aryl; substituted aryl; arylalkyl and heterocycle;

R 3 and R 4 are each independently selected from hydrogen; C 1 -C 4 alkyl; aryl and arylalkyl;

R 5 is selected from aryl, heteroaryl, heterocycle, C 1 -C 10 alkyl or C 1 -C 10 cycloaklyl, optionally substituted with one or more groups selected from hydrogen; mono-, di-, or trihalomethyl; C 1 -C 4 alkyl; C 3 -C 10 cycloalkyl; halo; heteroaryl; cyano; nitro; aryloxy;

aryl; alkoxy; arylalkoxy and NHC(O)R, wherein R is C 1 -C 4 alkyl; and

Y is (CR 6 R 7 ) n , wherein n is from 0-3, and R 6 and R 7 are independently selected from hydrogen;

C 1 -C 6 alkyl; C 3 -C 5 cycloalkyl; C 1 -C 4 alkylhydroxyl; mono- di-, or trihaloalkyl; and aryl; R 6 and R 7 may also come together to form a C 3 -C 6 cycloalkyl; or

when R 5 is phenyl, one of R 6 or R 7 comes together with R 5 to form a bicycle