ROBUST TRIAL DESIGN PLATFORM

1 .- 515 . (canceled)

516 . A method comprising:

receiving, via at least one processor, output data of a plurality of trial design simulations for a plurality of scenarios;

evaluating, via the at least one processor, the output data to determine changes in performance over the plurality of scenarios;

generating, via the at least one processor, visual tornado diagram data structured to generate a visual tornado diagram on an electronic display of an electronic device, and

transmitting, via the at least one processor, the visual tornado diagram data to the electronic device.

517 . The method of claim 516 further comprising:

determining, via the at least one processor, a span of acceptable performance values over the scenarios.

518 . The method of claim 516 further comprising:

determining, via the at least one processor, a robustness value based at least in part on the changes.

519 . The method of claim 518 , wherein the robustness value is based on a probability associated with each scenario.

520 . The method of claim 519 further comprising:

determining, via the at least one processor, a risk assessment value based at least in part on the robustness value.

521 . The method of claim 516 further comprising:

categorizing, via the at least one processor, scenarios based on their probability.

522 . The method of claim 521 , wherein the scenarios are categorized as at least one of optimistic, base, or pessimistic.

523 . The method of claim 522 further comprising:

determining, via the at least one processor, a robustness value based on a score value in each of the scenario categories.

524 . The method of claim 516 further comprising:

determining, via the at least one processor, scenario parameters that have the largest impact on performance parameters.

525 . The method of claim 524 further comprising:

determining, via the at least one processor, weighting criteria data for the scenario parameters; and

determining, via the at least one processor, a robustness value of a trial design of the plurality based at least in part on the weighting criteria.

526 . The method of claim 516 , further comprising:

evaluating historical trial design selections to identify one or more trial design parameters based at least in part on one or more trial design criteria determined from a user via an interactive interface, wherein receiving the output data of the plurality of trial design simulations is based at least in part on a quick search data structure and the one or more trial design parameters;

generating a substitute for at least some of the output data based at least in part on a relationship between the plurality of trial design simulations and supplemental data;

generating a performance surface based at least in part on a set of trial designs corresponding to the trial design simulations;

evaluating one or more trial designs based at least in part on the performance surface; and

calculating a score based on normalized score component values corresponding to the plurality of trial design simulations.

527 . An apparatus comprising:

an output processing circuit structured to interpret output data of a plurality of trial design simulations for a plurality of scenarios;

an evaluation circuit structured to evaluate the output data to determine differences in performance over the plurality of scenarios;

a graphic generation circuit structured to generate a tornado diagram that visualizes differences; and

a graphic provisioning circuit structured to transmit the tornado diagram.

528 . The apparatus of claim 527 further comprising:

a robustness circuit structured to determine a span of acceptable performance values over the scenarios.

529 . The apparatus of claim 528 further comprising:

a robustness circuit structured to determine a robustness value based at least in part on changes in performance.

530 . A non-transitory computer-readable medium storing instructions that adapt at least one processor to:

receive outputs of a plurality of trial design simulations for a plurality of scenarios;

evaluate the outputs to determine changes in performance over the plurality of scenarios; and

provide a visual tornado diagram to visualize the changes.

531 . The non-transitory computer-readable medium of claim 530 , wherein evaluating the outputs comprises:

generating a visualization.

532 . The non-transitory computer-readable medium of claim 531 , wherein the visualization is a tornado diagram.

533 . The non-transitory computer-readable medium of claim 530 , wherein the stored instructions further adapt the at least one processor to:

determine a robustness value based at least in part on the changes.

534 . The non-transitory computer-readable medium of claim 533 , wherein the stored instructions further adapt the at least one processor to:

determine a risk assessment based at least in part on the robustness value.

535 . The non-transitory computer-readable medium of claim 530 , wherein the stored instructions further adapt the at least one processor to:

determine scenario parameters that have the largest impact on performance parameters.

536 .- 696 . (canceled)