HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
1 .- 15 . (canceled)
16 . A method of lowering LDL cholesterol in a human, comprising administering orally to a human in need of such treatment a therapeutically effective amount of a compound represented by:
17 . The method of claim 16 , wherein the compound is administered orally to the human in the form of a pharmaceutical composition comprising the compound, and a pharmaceutically acceptable vehicle.
18 . The method of claim 16 , wherein the human has familial hypercholesterolemia.
19 . The method of claim 16 , wherein the human has cardiovascular disease.
20 . The method of claim 19 , wherein the cardiovascular disease is atherosclerotic cardiovascular disease.
21 . The method of claim 17 , wherein the human has familial hypercholesterolemia.
22 . The method of claim 17 , wherein the human has cardiovascular disease.
23 . The method of claim 22 , wherein the cardiovascular disease is atherosclerotic cardiovascular disease.