Compositions and methods of treating retinal disease
Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed.
1. A method of treating macular degeneration in a subject, the method comprising administering to the subject a compound of the following structure:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the macular degeneration is age related macular degeneration (AMD).
3. The method of claim 2 , wherein the AMD is wet AMD.
4. The method of claim 2 , wherein the AMD is dry AMD.
5. The method of claim 1 , wherein the macular degeneration is Stargardt's disease.
6. The method of claim 1 , wherein the compound is administered topically to the eye of the subject.
7. The method of claim 1 , wherein the compound is administered as an eye-drop or ophthalmic ointment.
8. The method of claim 1 , wherein the compound is administered by intraocular injection.
9. The method of claim 8 , wherein the compound is