Stabilized stannous compositions
The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.
1. A method of mineralizing a dental surface or subsurface, comprising contacting the dental surface or subsurface with (i) a compound capable of increasing or maintaining a pH of a solution and (ii) a stannous-associated phosphopeptide-stabilized amorphous calcium phosphate (ACP) complex and/or a stannous-associated phosphopeptide-stabilized amorphous calcium fluoride phosphate (ACFP) complex, wherein the complex has a stannous ion content of at least 1 mole of stannous per mole of phosphopeptide.
2. The method according to claim 1 , wherein the compound capable of increasing or maintaining the pH of a solution is a base.
3. The method according to claim 1 , wherein the dental surface is a lesion in enamel caused by caries, dental erosion, or fluorosis.
4. The method according to claim 1 , wherein the complex has a stannous ion content of at least 5 moles of stannous per mole of phosphopeptide.
5. The method according to claim 1 , wherein the complex has a stannous ion content of about 7 moles of stannous per mole of phosphopeptide.
6. The method according to claim 1 , wherein the stannous of the complex is provided by a stannous compound selected from the group consisting of stannous fluoride, stannous chloride, potassium stannous fluoride, sodium stannous fluorozirconate, stannous chloride fluoride, stannous acetate, sodium stannous fluoride, stannous hexafluorozirconate, stannous sulfate, stannous tartrate, stannous gluconate, and disodium monostannous citrate.
7. The method according to claim 1 , wherein the stannous compound is stannous fluoride.
8. The method according to claim 1 , wherein the method comprises contacting the dental surface or subsurface with a stannous-associated phosphopeptide-stabilized ACFP complex, wherein the fluoride of the ACFP is provided by sodium fluoride and stannous fluoride.
9. The method according to claim 1 , wherein the complex is in a form selected from a toothpaste, toothpowder, liquid dentifrice, mouthwash, mouthrinse, mouth spray, varnish, dental cement, troche, chewing gum, lozenge, dental paste, gingival massage cream, gargle tablet, dairy product or other foodstuffs.
10. The method according to claim 1 , wherein the compound capable of increasing or maintaining the pH of a solution and the complex simultaneously contact the dental surface or sub surface.
11. The method according to claim 1 , wherein the compound capable of increasing or maintaining the pH of a solution contacts the dental surface or subsurface after complex.
12. The method according to claim 1 , wherein the compound capable of increasing or maintaining the pH of a solution is capable of producing hydroxide ions.
13. The method according to claim 1 , wherein the compound capable of increasing or maintaining the pH of a solution is capable of maintaining the pH of a solution at between pH 7 to pH 9.
14. The method according to claim 1 , wherein the compound capable of increasing or maintaining the pH of a solution is provided in an amount effective to raise the pH of intra-lesion fluid of a dental lesion from pH 6 to pH 7.5.
15. The method according to claim 1 , wherein the compound capable of increasing or maintaining the pH of a solution is selected from sodium bicarbonate, sodium hypochlorite, and urea.
16. The method according to claim 15 , wherein the sodium bicarbonate is provided in the form of a mouthrinse or mouthwash.
17. The method according to claim 1 , wherein the dental surface or subsurface is of a domestic animal, companion animal, or zoo animal.
18. The method according to claim 17 , wherein the dental surface or subsurface is of a cat or dog.
19. The method according to claim 17 , wherein the dental surface or subsurface is of a domestic animal selected from the group consisting of cattle, sheep, horses and poultry.