Heterocyclic compounds, preparation and methods and uses thereof
Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).
1. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is
2. A compound, which is
3. A pharmaceutical composition comprising the compound of claim 2 and a pharmaceutically acceptable excipient.
4. A method of treating cancer associated with KRAS G12C in a subject, the method comprising administering to the subject a therapeutically effective amount of the compound of claim 2 .
5. The method of claim 4 , wherein the cancer is a hematologic malignancy, lung cancer, pancreatic cancer, endometrial cancer, gall bladder cancer, thyroid cancer, bile duct cancer, and/or colorectal cancer.
6. A method of treating cancer associated with KRAS G12C in a subject, the method comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 2 .
7. The method of claim 6 , wherein the cancer is a hematologic malignancy, lung cancer, pancreatic cancer, endometrial cancer, gall bladder cancer, thyroid cancer, bile duct cancer, and/or colorectal cancer.
8. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
9. A method of treating cancer associated with KRAS G12C in a subject, the method comprising administering to the subject a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
10. The method of claim 9 , wherein the cancer is a hematologic malignancy, lung cancer, pancreatic cancer, endometrial cancer, gall bladder cancer, thyroid cancer, bile duct cancer, and/or colorectal cancer.