Prodrugs of monomethyl fumarate
Provided herein are novel monomethyl fumarate prodrugs.
1. A compound according to the following formula:
and, optionally, wherein the counterion iodine is substituted with acetate, benzoate, bitartrate, bromide, chloride, citrate, estolate, fumarate, gluceptate, gluconate, lactate, lactobionate, malate, maleate, mandelate, mesylate, methyl sulfate, mucate, nitrate, phosphate, diphosphate, stearate, succinate, sulfate, tartrate, tosylate, or valerate.
2. The compound of claim 1 , wherein the compound is
and, optionally, wherein the counterion iodine is substituted with acetate, benzoate, bitartrate, bromide, chloride, citrate, estolate, fumarate, gluceptate, gluconate, lactate, lactobionate, malate, maleate, mandelate, mesylate, methyl sulfate, mucate, nitrate, phosphate, diphosphate, stearate, succinate, sulfate, tartrate, tosylate, or valerate.
3. The compound of claim 1 , wherein the compound is
and, optionally, wherein the counterion iodine is substituted with acetate, benzoate, bitartrate, bromide, chloride, citrate, estolate, fumarate, gluceptate, gluconate, lactate, lactobionate, malate, maleate, mandelate, mesylate, methyl sulfate, mucate, nitrate, phosphate, diphosphate, stearate, succinate, sulfate, tartrate, tosylate, or valerate.
4. The compound of claim 1 , wherein the compound is
and, optionally, wherein the counterion iodine is substituted with acetate, benzoate, bitartrate, bromide, chloride, citrate, estolate, fumarate, gluceptate, gluconate, lactate, lactobionate, malate, maleate, mandelate, mesylate, methyl sulfate, mucate, nitrate, phosphate, diphosphate, stearate, succinate, sulfate, tartrate, tosylate, or valerate.
5. A compound according to the following formula:
6. A compound according to the following formula:
and, optionally, wherein the counterion iodine is substituted with acetate, benzoate, bitartrate, bromide, chloride, citrate, estolate, fumarate, gluceptate, gluconate, lactate, lactobionate, malate, maleate, mandelate, mesylate, methyl sulfate, mucate, nitrate, phosphate, diphosphate, stearate, succinate, sulfate, tartrate, tosylate, or valerate.