IP Library › Granted Patent US 12,208,073
Granted Patent B2
US 12,208,073 · App. 17/184,808 · Granted Jan 28, 2025

Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (HMB) for enhancing recovery from soft tissue trauma

Inventors: Shawn Baier (Polk City, IA); Naji Abumrad (Nashville, TN); Emily Harris (Grimes, IA)
Assignee: Metabolic Technologies, LLC
A61K31/19A61P19/04A61P21/00
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Quick Facts
Patent No.
US 12,208,073
App. No.
17/184,808
Granted
Jan 28, 2025
Kind
B2
Abstract

The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to enhance recovery from soft tissue trauma, including both acute and non-acute soft tissue trauma. Enhanced recovery includes reduced recovery time and enhanced soft tissue healing. Soft tissue trauma includes administration of a Botulinum toxin, such as Botox. Administration of HMB in association with administration of a Botulinum toxin increases muscle strength and/or function in muscle, including adjacent and/or contralateral muscles and prevents or lessens loss of contractile material.

Claims (12)

1. A method of increasing strength in muscle following administration of Botulinum toxin, comprising administering to a human in need thereof a composition comprising from about 0.5 to about 30 grams of β-hydroxy-β-methylbutyric acid (HMB), wherein the HMB further comprises HMB in its free acid form, its salt, its ester or its lactone.

2. The method of claim 1 , wherein strength is increased in the injected muscle.

3. The method of claim 1 , wherein strength is increased in neighboring muscle.

4. The method of claim 1 , wherein strength is increased in at least one contralateral muscle.

5. The method of claim 1 , wherein the Botulinum toxin further comprises onabotulinumtoxinA, incobotulinumtoxinA, rimabotulinumtoxinB, abobotulinumtoxinA, or prabotulinumtoxinA-xvfs.

6. A method of lessening or preventing the loss of contractile material in muscle following administration of Botulinum toxin, comprising administering to a human in need thereof a composition comprising from about 0.5 to about 30 grams of β-hydroxy-β-methylbutyric acid (HMB), wherein the HMB further comprises HMB in its free acid form, its salt, its ester or its lactone.

7. The method of claim 6 , wherein the lessening or preventing of the loss of contractile material is in a neighboring muscle.

8. The method of claim 6 , wherein the lessening or preventing of the loss of contractile material is in contralateral muscle.

9. The method of claim 6 , wherein the Botulinum toxin further comprises onabotulinumtoxinA, incobotulinumtoxinA, rimabotulinomtoxinB, abobotulinumtoxinA, or prabotulinumtoxinA-xvfs.

10. A method lessening the side effects of administration of at least one Botulinum toxins, comprising administering to a human in need thereof a composition comprising from about 0.5 to about 30 grams of β-hydroxy-β-methylbutyric acid (HMB), wherein the HMB further comprises HMB in its free acid form, its salt, its ester or its lactone.

11. The method of claim 10 , wherein the side effects further comprise at least one of loss of muscle strength, loss of muscle function, and loss of contractile material.

12. The method of claim 10 , wherein the Botulinum toxin further comprises onabotulinumtoxinA, incobotulinumtoxinA, rimabotulinumtoxinB, abobotulinumtoxinA, or prabotulinumtoxinA-xvfs.

Assignments (2)
CHANGE OF NAME Recorded Sep 26, 2024
From: METABOLIC TECHNOLOGIES, INC.
To: METABOLIC TECHNOLOGIES, LLC
Reel/Frame 068710/0573 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 24, 2024
From: BAIER, SHAWN; ABUMRAD, NAJI; HARRIS, EMILY
To: METABOLIC TECHNOLOGIES, INC.
Reel/Frame 068072/0243 →
Continuity (4)
Continuation In Part 17006422 · Aug 28, 2020
Continuation 15267717 · Sep 16, 2016
Provisional Application 62219208 · Sep 16, 2015
Related Publication 20210177785A1 · Jun 17, 2021
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