IP Library › Granted Patent US 12,226,186
Granted Patent B2
US 12,226,186 · App. 17/193,318 · Granted Feb 18, 2025

Devices, methods, and systems with spectral filtering for detecting wound and identifying bacteria based on fluorescence signature

Inventors: Ralph Sebastian Dacosta (Etobicoke, CA); Brian C. Wilson (Toronto, CA); Kai Zhang (Scarborough, CA)
Assignee: UNIVERSITY HEALTH NETWORK
A61B5/0071A61B5/0059A61B5/01A61B5/445A61B5/72A61B5/742G01N21/6456G01N21/6486A61B5/0042A61B5/4519A61B10/00G01N21/6408G01N2021/6421G01N2021/6471G01N2201/0221Y02A90/10
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Quick Facts
Patent No.
US 12,226,186
App. No.
17/193,318
Granted
Feb 18, 2025
Kind
B2
Abstract

A system for acquiring data regarding a wound in tissue comprises at least one excitation light source configured to directly illuminate a wound with excitation light; a spectral filtering mechanism configured to permit passage of optical signals responsive to illumination of the wound and having at least one wavelength corresponding to bacterial, fungal, and/or other microorganism autofluorescence and/or bacterial, fungal, viral, and/or microbial fluorescence, the spectral filtering mechanism including a plurality of selectable filters respectively corresponding to different discrete spectral bandwidths; an optical sensor configured to detect the spectrally filtered signals; and a processor configured to receive the detected, filtered signals and to identify a fluorescent signature of bacteria in the wound based at least in part on the detected, filtered signals and to output data regarding the bacterial, fungal, viral, and/or microbial fluorescent signature.

Claims (33)

1. A handheld, portable imaging system for acquiring data regarding a wound in tissue, comprising:

at least one excitation light source configured to illuminate a wound with excitation light and comprising at least one wavelength or wavelength band causing at least one biomarker in the illuminated wound to fluoresce;

a spectral filtering mechanism configured to permit passage of optical signals responsive to illumination of the wound and having a wavelength corresponding to bacterial autofluorescence and/or bacterial fluorescence, the spectral filtering mechanism including a plurality of selectable filters respectively corresponding to different discrete spectral bandwidths;

a mobile communication device having an image sensor to detect the spectrally filtered signals, wherein the mobile communication device is a cellular telephone, a smartphone, a laptop computer, a tablet computer, or a personal digital assistant,

wherein the plurality of selectable filters is movable relative to the image sensor so as to position a selected filter of the plurality of selectable filters between the wound and the image sensor to detect the spectrally filtered signals corresponding to the discrete spectral bandwidths of the selected filter;

a housing, separate from the mobile communication device, to support the at least one excitation light source and the spectral filtering mechanism relative to the mobile communication device during imaging and configured to receive at least a portion of the mobile communication device therein; wherein the spectral filtering mechanism includes a triple band-pass filter; and

a processor configured to receive the detected, filtered signals, to spatially and/or temporally co-register one or more of endogenous fluorescence data, exogenous fluorescence data, absorbance data, and reflectance data contained in the detected, filtered signals, and to identify a fluorescent signature of bacteria in the wound based at least in part on the data contained in the detected, filtered signals, and to output data regarding the bacterial fluorescent signature.

2. The system according to claim 1 , further comprising a memory storing fluorescence, absorbance, and/or reflectance spectral data of biological, tissue, cellular, and molecular components and/or biomarkers and non-biological materials for comparison with fluorescence, absorbance, and/or reflectance detected in and/or around the wound.

3. The system according to claim 2 , wherein the memory is configured to store the fluorescence, absorbance, and/or reflectance spectral data of biological, tissue, cellular, and molecular components and/or biomarkers and non-biological materials in a look-up table.

4. The system according to claim 1 , wherein the spectral filtering mechanism is further configured to permit passage of optical signals responsive to illumination of the wound and having a wavelength corresponding to tissue autofluorescence and wherein the output data comprises at least one fluorescent representation of bacteria and tissue components present in the wound.

5. The system according to claim 4 , wherein the processor is configured to analyze the at least one fluorescent representation in order to recognize, classify, and/or quantify various components of the wound, based on received signals or the output data.

6. The system according to claim 1 , wherein the image sensor is configured to detect the spectrally filtered signals a plurality of times at predetermined intervals.

7. The system according to claim 1 , further comprising a wireless data transfer port configured to transmit the data regarding the bacterial fluorescent signature to an external device.

8. The system according to claim 7 , wherein the data transfer port is configured to communicate via a Bluetooth protocol.

9. The system according to claim 1 , wherein the at least one excitation light source is configured to emit excitation light having a wavelength of about 400 nm to about 450 nm.

10. The system according to claim 1 , wherein the spectral filtering mechanism is configured to permit passage of optical signals having wavelengths within one or more of the following ranges: 405 nm±25 nm, 546 nm±25 nm, 600 nm±25 nm, about 490 nm to about 550 nm, and about 590 nm to about 650 nm.

11. The system according to claim 1 , further comprising a white-light source for white-light imaging.

12. The system according to claim 1 , wherein the at least one excitation light source includes a first excitation light source configured to emit excitation light having a first wavelength or wavelength band and a second excitation light source configured to emit excitation light having a second wavelength or wavelength band, the first wavelength or wavelength band being different than the second wavelength or wavelength band.

13. The system according to claim 1 , wherein the spectral filtering mechanism further comprises one or more polarization filters.

14. The system according to claim 1 , wherein the at least one excitation light source comprises at least one polarization filter.

15. The system according to claim 1 , wherein the at least one excitation light source is a plurality of excitation light sources, and respective ones of the plurality of excitation light sources are configured to emit light in an ultraviolet, visible, far-red, near infrared, and/or infrared range.

16. The system according to claim 1 , wherein the processor is a processor of the mobile communication device.

17. The system according to claim 1 , wherein the plurality of selectable filters respectively corresponding to different discrete spectral bandwidths includes a triple bandpass filter configured to separate narrow bandwidths of blue, green and red reflected light components from the wound.

18. The system according to claim 17 , wherein the processor is further configured to receive the filtered, reflected light components, and to output an image of the presence of blood and/or microvascular networks in the wound and surround tissues based at least in part on the data contained in the filtered reflected light components.

19. The system according to claim 17 , wherein the processor is further configured to receive the filtered, reflected light components and to output an image indicating the presence of blood containing both oxygenated and deoxygenated hemoglobin.

20. A handheld, portable system for acquiring data regarding a wound in tissue, comprising:

at least one excitation light source configured to illuminate a wound with excitation light and comprising at least one wavelength or wavelength band causing at least one biomarker in the illuminated wound to fluoresce;

a spectral filtering mechanism configured to permit passage of optical signals responsive to illumination of the wound and having a wavelength corresponding to bacterial autofluorescence and/or bacterial fluorescence, the spectral filtering mechanism including a plurality of selectable filters respectively corresponding to different discrete spectral bandwidths;

a mobile communication device having an image sensor to detect the spectrally filtered signals, wherein the mobile communication device is a cellular telephone, a smartphone, a laptop computer, a tablet computer, or a personal digital assistant,

wherein the plurality of selectable filters is movable relative to the image sensor so as to position a selected filter of the plurality of selectable filters between the wound and the image sensor to detect the spectrally filtered signals corresponding to the discrete spectral bandwidths of the selected filter;

a housing, separate from the mobile communication device, to support the at least one excitation light source relative to the mobile communication device during imaging and configured to receive at least a portion of the mobile communication device therein; and

a processor configured to receive the detected, filtered signals, to spatially and/or temporally co-register one or more of endogenous fluorescence data, exogenous fluorescence data, absorbance data, and reflectance data contained in the detected, filtered signals, and to identify a fluorescent signature of bacteria in the wound based at least in part on the data contained in the detected, filtered signals, and to output data regarding the bacterial fluorescent signature, wherein

the processor is further configured to correlate bacterial autofluorescence data and bacterial fluorescence data contained in the detected, spectrally-filtered signals to provide an indication of wound infection.

Assignments (3)
SECURITY INTEREST Recorded Jan 31, 2022
From: MOLECULIGHT INC.
To: SWK FUNDING LLC
Reel/Frame 058917/0083 →
CORRECTIVE ASSIGNMENT TO CORRECT THE THIRD INVENTOR'S NAME PREVIOUSLY RECORDED AT REEL: 055519 FRAME: 0659. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT . Recorded Mar 10, 2021
From: DACOSTA, RALPH S.; WILSON, BRIAN C.; ZHANG, KAI
To: UNIVERSITY HEALTH NETWORK
Reel/Frame 056555/0229 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 8, 2021
From: DACOSTA, RALPH S.; WILSON, BRIAN C.; ZHANHG, KAI
To: UNIVERSITY HEALTH NETWORK
Reel/Frame 055519/0659 →
Continuity (4)
Continuation 14719493 · May 22, 2015
Continuation 12992040
Provisional Application 61054780 · May 20, 2008
Related Publication 20210259552A1 · Aug 26, 2021
References Cited (400)
US 4556057A · Hiruma et al. · 1985 [cited by applicant]
US 4740459A · Chen · 1988 [cited by examiner]
US 4859063A · Fay · 1989 [cited by examiner]
US 5306144A · Hibst et al. · 1994 [cited by applicant]
US 5421337A · Richards-Kortum et al. · 1995 [cited by applicant]
US 5456260A · Kollias et al. · 1995 [cited by applicant]
US 5474910A · Alfano · 1995 [cited by applicant]
US 5482041A · Wilk et al. · 1996 [cited by applicant]
US 5507287A · Palcic et al. · 1996 [cited by applicant]
US 5522868A · Buckley et al. · 1996 [cited by applicant]
US 5533508A · Doiron · 1996 [cited by applicant]
US 5552134A · Morgan et al. · 1996 [cited by applicant]
US 5562100A · Kittrell et al. · 1996 [cited by applicant]
US 5566673A · Shiono et al. · 1996 [cited by applicant]
US 5569911A · Tomlinson, Jr. et al. · 1996 [cited by applicant]
US 5572996A · Doiron et al. · 1996 [cited by applicant]
US 5579773A · Vo-Dinh et al. · 1996 [cited by applicant]
US 5588428A · Smith et al. · 1996 [cited by applicant]
US 5590660A · MacAulay et al. · 1997 [cited by applicant]
US 5605152A · Slate et al. · 1997 [cited by applicant]
US 5612540A · Richards-Kortum et al. · 1997 [cited by applicant]
US 5623932A · Ramanujam et al. · 1997 [cited by applicant]
US 5626134A · Zuckerman · 1997 [cited by applicant]
US 5628310A · Rao et al. · 1997 [cited by applicant]
US 5647368A · Zeng et al. · 1997 [cited by applicant]
US 5687730A · Doiron et al. · 1997 [cited by applicant]
US 5690417A · Polidor et al. · 1997 [cited by applicant]
US 5697373A · Richards-Kortum et al. · 1997 [cited by applicant]
US 5701902A · Vari et al. · 1997 [cited by applicant]
US 5760407A · Margosiak et al. · 1998 [cited by applicant]
US 5769792A · Palcic et al. · 1998 [cited by applicant]
US 5770454A · Essenpreis et al. · 1998 [cited by applicant]
US 5779631A · Chance · 1998 [cited by applicant]
US 5813987A · Modell et al. · 1998 [cited by applicant]
US 5820558A · Chance · 1998 [cited by applicant]
US 5849595A · Alfano et al. · 1998 [cited by applicant]
US 5851181A · Talmor · 1998 [cited by applicant]
US 5865754A · Sevick-Muraca et al. · 1999 [cited by applicant]
US 5879294A · Anderson et al. · 1999 [cited by applicant]
US 5935075A · Casscells et al. · 1999 [cited by applicant]
US 5952664A · Wake et al. · 1999 [cited by applicant]
US 5981958A · Li et al. · 1999 [cited by applicant]
US 5986271A · Lazarev et al. · 1999 [cited by applicant]
US 6002137A · Hayashi · 1999 [cited by applicant]
US 6008889A · Zeng et al. · 1999 [cited by applicant]
US 6014204A · Prahl et al. · 2000 [cited by applicant]
US 6021344A · Lui et al. · 2000 [cited by applicant]
US 6026319A · Hayashi · 2000 [cited by applicant]
US 6036941A · Bottiroli et al. · 2000 [cited by applicant]
US 6055451A · Bambot et al. · 2000 [cited by applicant]
US 6058324A · Chance · 2000 [cited by applicant]
US 6061591A · Freitag et al. · 2000 [cited by applicant]
US 6064897A · Lindberg et al. · 2000 [cited by applicant]
US 6064899A · Fein et al. · 2000 [cited by applicant]
US 6069689A · Zeng et al. · 2000 [cited by applicant]
US 6078833A · Hueber · 2000 [cited by applicant]
US 6081612A · Gutkowicz-Krusin et al. · 2000 [cited by applicant]
US 6081739A · Lemchen · 2000 [cited by applicant]
US 6088087A · Graves et al. · 2000 [cited by applicant]
US 6088606A · Ignotz et al. · 2000 [cited by applicant]
US 6091984A · Perelman et al. · 2000 [cited by applicant]
US 6091985A · Alfano et al. · 2000 [cited by applicant]
US 6095982A · Richards-Kortum et al. · 2000 [cited by applicant]
US 6104939A · Groner et al. · 2000 [cited by applicant]
US 6104945A · Modell et al. · 2000 [cited by applicant]
US 6122042A · Wunderman et al. · 2000 [cited by applicant]
US 6122536A · Sun et al. · 2000 [cited by applicant]
US 6124597A · Shehada et al. · 2000 [cited by applicant]
US 6128516A · Macfarlane et al. · 2000 [cited by applicant]
US 6128525A · Zeng et al. · 2000 [cited by applicant]
US 6129664A · Macfarlane et al. · 2000 [cited by applicant]
US 6135965A · Tumer et al. · 2000 [cited by applicant]
US 6142629A · Adel et al. · 2000 [cited by applicant]
US 6148227A · Wagnieres et al. · 2000 [cited by applicant]
US 6161031A · Hochman et al. · 2000 [cited by applicant]
US 6167297A · Benaron · 2000 [cited by applicant]
US 6192261B1 · Gratton et al. · 2001 [cited by applicant]
US 6205354B1 · Gellermann et al. · 2001 [cited by applicant]
US 6208749B1 · Gutkowicz-Krusin et al. · 2001 [cited by applicant]
US 6212425B1 · Irion et al. · 2001 [cited by applicant]
US 6219566B1 · Weersink et al. · 2001 [cited by applicant]
US 6223071B1 · Lundahl et al. · 2001 [cited by applicant]
US 6236871B1 · Tsuchiya · 2001 [cited by applicant]
US 6236881B1 · Zahler et al. · 2001 [cited by applicant]
US 6238348B1 · Crowley et al. · 2001 [cited by applicant]
US 6241662B1 · Richards-Kortum et al. · 2001 [cited by applicant]
US 6256530B1 · Wolfe · 2001 [cited by applicant]
US 6258576B1 · Richards-Kortum et al. · 2001 [cited by applicant]
US 6272367B1 · Chance · 2001 [cited by applicant]
US 6272376B1 · Marcu et al. · 2001 [cited by applicant]
US 6280386B1 · Alfano et al. · 2001 [cited by applicant]
US 6289236B1 · Koenig et al. · 2001 [cited by applicant]
US 6304766B1 · Colvin, Jr. · 2001 [cited by applicant]
US 6317624B1 · Kollias et al. · 2001 [cited by applicant]
US 6343227B1 · Crowley · 2002 [cited by applicant]
US 6364829B1 · Fulghum · 2002 [cited by applicant]
US 6373568B1 · Miller et al. · 2002 [cited by applicant]
US 6385484B2 · Nordstrom et al. · 2002 [cited by applicant]
US 6393315B1 · Aprahamian et al. · 2002 [cited by applicant]
US 6422994B1 · Kaneko et al. · 2002 [cited by applicant]
US 6427082B1 · Nordstrom et al. · 2002 [cited by applicant]
US 6436127B1 · Anderson et al. · 2002 [cited by applicant]
US 6442416B1 · Schultz · 2002 [cited by applicant]
US 6465968B1 · Sendai · 2002 [cited by applicant]
US 6473637B1 · Hayashi · 2002 [cited by applicant]
US 6487428B1 · Culver et al. · 2002 [cited by applicant]
US 6496719B2 · Hayashi · 2002 [cited by applicant]
US 6510338B1 · Irion et al. · 2003 [cited by applicant]
US 6522911B1 · Toida et al. · 2003 [cited by applicant]
US 6526309B1 · Chance · 2003 [cited by applicant]
US 6542772B1 · Chance · 2003 [cited by applicant]
US 6549801B1 · Chen et al. · 2003 [cited by applicant]
US 6563105B2 · Seibel et al. · 2003 [cited by applicant]
US 6571119B2 · Hayashi · 2003 [cited by applicant]
US 6573513B2 · Hayashi · 2003 [cited by applicant]
US 6574502B2 · Hayashi · 2003 [cited by applicant]
US 6577394B1 · Zavislan · 2003 [cited by applicant]
US 6577884B1 · Boas · 2003 [cited by applicant]
US 6580941B2 · Webb · 2003 [cited by applicant]
US 6582363B2 · Adachi et al. · 2003 [cited by applicant]
US 6584342B1 · Trushin et al. · 2003 [cited by applicant]
US 6590651B1 · Bambot et al. · 2003 [cited by applicant]
US 6597932B2 · Tian et al. · 2003 [cited by applicant]
US 6600947B2 · Averback et al. · 2003 [cited by applicant]
US 6603126B2 · Yamada et al. · 2003 [cited by applicant]
US 6603552B1 · Cline et al. · 2003 [cited by applicant]
US 6615063B1 · Ntziachristos et al. · 2003 [cited by applicant]
US 6622032B1 · Robinson et al. · 2003 [cited by applicant]
US 6631286B2 · Pfeiffer et al. · 2003 [cited by applicant]
US 6631289B2 · Alfano et al. · 2003 [cited by applicant]
US 6636759B2 · Robinson · 2003 [cited by applicant]
US 6639668B1 · Trepagnier · 2003 [cited by applicant]
US 6640124B2 · Elsner et al. · 2003 [cited by applicant]
US 6640130B1 · Freeman et al. · 2003 [cited by applicant]
US 6640131B1 · Irion et al. · 2003 [cited by applicant]
US 6652836B2 · Luiken · 2003 [cited by applicant]
US 6665556B1 · Alfano et al. · 2003 [cited by applicant]
US 6667803B1 · Flessland et al. · 2003 [cited by applicant]
US 6668186B1 · Zavislan et al. · 2003 [cited by applicant]
US 6678398B2 · Wolters et al. · 2004 [cited by applicant]
US 6690466B2 · Miller et al. · 2004 [cited by applicant]
US 6694158B2 · Polak · 2004 [cited by applicant]
US 6697652B2 · Georgakoudi et al. · 2004 [cited by applicant]
US 6697657B1 · Shehada et al. · 2004 [cited by applicant]
US 6697666B1 · Richards-Kortum et al. · 2004 [cited by applicant]
US 6701168B1 · Wilson et al. · 2004 [cited by applicant]
US 6709446B2 · Lundahl et al. · 2004 [cited by applicant]
US 6711429B1 · Gilboa et al. · 2004 [cited by applicant]
US 6721582B2 · Trepagnier et al. · 2004 [cited by applicant]
US 6730113B2 · Eckhardt et al. · 2004 [cited by applicant]
US 6738659B2 · Hsu · 2004 [cited by applicant]
US 6748259B1 · Benaron et al. · 2004 [cited by applicant]
US 6750964B2 · Evenson et al. · 2004 [cited by applicant]
US 6751490B2 · Esenaliev et al. · 2004 [cited by applicant]
US 6757554B2 · Rubinstein et al. · 2004 [cited by applicant]
US 6763262B2 · Hohla et al. · 2004 [cited by applicant]
US 6766184B2 · Utzinger et al. · 2004 [cited by applicant]
US 6768918B2 · Zelenchuk · 2004 [cited by applicant]
US 6778846B1 · Martinez et al. · 2004 [cited by applicant]
US 6800057B2 · Tsujita et al. · 2004 [cited by applicant]
US 6806089B1 · Lakowicz et al. · 2004 [cited by applicant]
US 6818903B2 · Schomacker et al. · 2004 [cited by applicant]
US 6821289B2 · Bode et al. · 2004 [cited by applicant]
US 6826424B1 · Zeng et al. · 2004 [cited by applicant]
US 6865407B2 · Kimball et al. · 2005 [cited by applicant]
US 6868285B2 · Muller-Dethlefs · 2005 [cited by applicant]
US 6870620B2 · Faupel et al. · 2005 [cited by applicant]
US 6873716B1 · Bowker et al. · 2005 [cited by applicant]
US 6912412B2 · Georgakoudi et al. · 2005 [cited by applicant]
US 6914250B2 · Seville · 2005 [cited by applicant]
US 6922523B2 · Merola et al. · 2005 [cited by applicant]
US 6922576B2 · Raskas · 2005 [cited by applicant]
US 6930773B2 · Cronin et al. · 2005 [cited by applicant]
US 6933154B2 · Schomacker et al. · 2005 [cited by applicant]
US 6936004B2 · Utsui · 2005 [cited by applicant]
US 6970729B2 · Hartmann · 2005 [cited by applicant]
US 6975898B2 · Seibel · 2005 [cited by applicant]
US 6975899B2 · Faupel et al. · 2005 [cited by applicant]
US 6984228B2 · Anderson et al. · 2006 [cited by applicant]
US 6992762B2 · Long et al. · 2006 [cited by applicant]
US 7006223B2 · Mullani · 2006 [cited by applicant]
US 7016714B2 · Colvin, Jr. · 2006 [cited by applicant]
US 7016717B2 · Demos et al. · 2006 [cited by applicant]
US 7027153B2 · Mullani · 2006 [cited by applicant]
US 7062311B1 · Sendai et al. · 2006 [cited by applicant]
US 7102142B2 · Sendai · 2006 [cited by applicant]
US 7103401B2 · Schomacker et al. · 2006 [cited by applicant]
US 7107116B2 · Geng · 2006 [cited by applicant]
US 7113814B2 · Ward et al. · 2006 [cited by applicant]
US 7127282B2 · Nordstrom et al. · 2006 [cited by applicant]
US 7130672B2 · Pewzner et al. · 2006 [cited by applicant]
US 7139598B2 · Hull et al. · 2006 [cited by applicant]
US 7139603B2 · Chance · 2006 [cited by applicant]
US 7149567B2 · Demos et al. · 2006 [cited by applicant]
US 7151270B2 · Birk et al. · 2006 [cited by applicant]
US 7167243B2 · Mullani · 2007 [cited by applicant]
US 7167244B2 · Mullani · 2007 [cited by applicant]
US 7197355B2 · Nelson · 2007 [cited by applicant]
US 7202947B2 · Liu et al. · 2007 [cited by applicant]
US 7209773B2 · Iuliano · 2007 [cited by applicant]
US 7212848B1 · Wake et al. · 2007 [cited by applicant]
US 7218822B2 · Treado et al. · 2007 [cited by applicant]
US 7224468B2 · Fouquet · 2007 [cited by applicant]
US RE39672E · Shehada et al. · 2007 [cited by applicant]
US 7236815B2 · Richards-Kortum et al. · 2007 [cited by applicant]
US 7242997B2 · Geng · 2007 [cited by applicant]
US 7248182B2 · Dudda et al. · 2007 [cited by applicant]
US 7257437B2 · Demos et al. · 2007 [cited by applicant]
US 7277210B2 · Lipson · 2007 [cited by applicant]
US 7282723B2 · Schomacker et al. · 2007 [cited by applicant]
US 7283858B2 · Sendai · 2007 [cited by applicant]
US 7286224B2 · Curry et al. · 2007 [cited by applicant]
US 7289836B2 · Colvin, Jr. · 2007 [cited by applicant]
US 7310547B2 · Zelenchuk · 2007 [cited by applicant]
US 7317938B2 · Lorenz et al. · 2008 [cited by applicant]
US 7321791B2 · Levenson et al. · 2008 [cited by applicant]
US 7324608B1 · Chiodini et al. · 2008 [cited by applicant]
US 7353055B2 · Hogan · 2008 [cited by applicant]
US 7359748B1 · Drugge · 2008 [cited by applicant]
US 7365844B2 · Richards-Kortum et al. · 2008 [cited by applicant]
US 7366365B2 · Carver · 2008 [cited by applicant]
US 7368694B2 · Goulas et al. · 2008 [cited by applicant]
US 7376346B2 · Merola et al. · 2008 [cited by applicant]
US 7376451B2 · Mahony et al. · 2008 [cited by applicant]
US 7378056B2 · Black · 2008 [cited by applicant]
US 7389132B2 · Wang et al. · 2008 [cited by applicant]
US 7403812B2 · Rice et al. · 2008 [cited by applicant]
US 7404929B2 · Fulghum, Jr. · 2008 [cited by applicant]
US 7454046B2 · Chhibber et al. · 2008 [cited by applicant]
US 7477393B2 · Sendai · 2009 [cited by applicant]
US 7477767B2 · Chhibber et al. · 2009 [cited by applicant]
US 7477931B2 · Hoyt · 2009 [cited by applicant]
US 7479990B2 · Imaizumi et al. · 2009 [cited by applicant]
US 7491956B2 · Knoche et al. · 2009 [cited by applicant]
US 7495233B2 · Pfister et al. · 2009 [cited by applicant]
US 7496392B2 · Alarcon et al. · 2009 [cited by applicant]
US 7499161B2 · Richards-Kortum et al. · 2009 [cited by applicant]
US 7505809B2 · Strommer et al. · 2009 [cited by applicant]
US 7508524B2 · Mahadevan-Jansen et al. · 2009 [cited by applicant]
US 7510699B2 · Black et al. · 2009 [cited by applicant]
US 7515952B2 · Balas et al. · 2009 [cited by applicant]
US 7519411B2 · Long · 2009 [cited by applicant]
US 7522797B2 · Treado et al. · 2009 [cited by applicant]
US 7526329B2 · Hogan et al. · 2009 [cited by applicant]
US 7536213B2 · Lipson et al. · 2009 [cited by applicant]
US 7539530B2 · Caplan et al. · 2009 [cited by applicant]
US 7555332B2 · Rice et al. · 2009 [cited by applicant]
US 7558619B2 · Ferguson et al. · 2009 [cited by applicant]
US 7564550B2 · Yaroslavsky et al. · 2009 [cited by applicant]
US 7570359B2 · Fox · 2009 [cited by applicant]
US 7570984B2 · Katsuda et al. · 2009 [cited by applicant]
US 7580185B2 · Haisch et al. · 2009 [cited by applicant]
US 7583993B2 · Sendai · 2009 [cited by applicant]
US 7587236B2 · Demos et al. · 2009 [cited by applicant]
US 7590437B2 · Rubinstein et al. · 2009 [cited by applicant]
US 7598088B2 · Balas · 2009 [cited by applicant]
US 7599065B2 · Sendai · 2009 [cited by applicant]
US 7599731B2 · Rice et al. · 2009 [cited by applicant]
US 7599732B2 · Sevick-Muraca et al. · 2009 [cited by applicant]
US 7603031B1 · Viaud et al. · 2009 [cited by applicant]
US 7609814B2 · Baumgart · 2009 [cited by applicant]
US 7610082B2 · Chance · 2009 [cited by applicant]
US 7613504B2 · Rowe · 2009 [cited by applicant]
US 7613505B2 · Mazuir et al. · 2009 [cited by applicant]
US 7633621B2 · Thornton · 2009 [cited by applicant]
US 7646002B2 · Sendai · 2010 [cited by applicant]
US 7652763B2 · Matousek et al. · 2010 [cited by applicant]
US 7653424B2 · March · 2010 [cited by applicant]
US 7672702B2 · Hwang et al. · 2010 [cited by applicant]
US 7697966B2 · Monfre et al. · 2010 [cited by applicant]
US 7697975B2 · Zeng · 2010 [cited by applicant]
US 7702381B2 · Gaeta et al. · 2010 [cited by applicant]
US 7722537B2 · Sterling et al. · 2010 [cited by applicant]
US 7729732B2 · Ohashi · 2010 [cited by applicant]
US 7729749B2 · Roessler et al. · 2010 [cited by applicant]
US 7734325B2 · Vizard et al. · 2010 [cited by applicant]
US 7738032B2 · Kollias et al. · 2010 [cited by applicant]
US 7749217B2 · Podhajsky · 2010 [cited by applicant]
US 7761126B2 · Gardner et al. · 2010 [cited by applicant]
US 7764303B2 · Pote et al. · 2010 [cited by applicant]
US 7785277B2 · Babaev et al. · 2010 [cited by applicant]
US 7787928B2 · Frisch et al. · 2010 [cited by applicant]
US 7794925B2 · Cullen · 2010 [cited by applicant]
US 7798955B2 · Ishihara et al. · 2010 [cited by applicant]
US 7804991B2 · Abovitz et al. · 2010 [cited by applicant]
US 7812945B2 · Fortier et al. · 2010 [cited by applicant]
US 7817267B2 · Carver · 2010 [cited by applicant]
US 7821640B2 · Koenig et al. · 2010 [cited by applicant]
US 7822450B2 · Colvin, Jr. et al. · 2010 [cited by applicant]
US 7826878B2 · Alfano et al. · 2010 [cited by applicant]
US 7843572B2 · Tearney et al. · 2010 [cited by applicant]
US 7860554B2 · Leonardi et al. · 2010 [cited by applicant]
US 7865231B2 · Tearney et al. · 2011 [cited by applicant]
US 7872759B2 · Tearney et al. · 2011 [cited by applicant]
US 7888659B2 · Scholz et al. · 2011 [cited by applicant]
US 7889348B2 · Tearney et al. · 2011 [cited by applicant]
US 7899518B2 · Trepagnier et al. · 2011 [cited by applicant]
US 7899624B2 · Cualing et al. · 2011 [cited by applicant]
US 7904140B2 · Pilon et al. · 2011 [cited by applicant]
US 7909253B2 · Sherman · 2011 [cited by applicant]
US 7912534B2 · Grinvald et al. · 2011 [cited by applicant]
US 7914442B1 · Gazdzinski · 2011 [cited by applicant]
US 7916283B2 · Fukutani et al. · 2011 [cited by applicant]
US 7925333B2 · Weir et al. · 2011 [cited by applicant]
US 7935055B2 · Burckhardt · 2011 [cited by applicant]
US 7945077B2 · Demos · 2011 [cited by applicant]
US 7960707B2 · Hall et al. · 2011 [cited by applicant]
US 7962200B2 · Nitziachristos et al. · 2011 [cited by applicant]
US 7966060B2 · Smit et al. · 2011 [cited by applicant]
US 7973925B2 · Lipson et al. · 2011 [cited by applicant]
US 7977650B2 · Laidevant et al. · 2011 [cited by applicant]
US 7979107B2 · Lin et al. · 2011 [cited by applicant]
US 7983736B2 · Villard et al. · 2011 [cited by applicant]
US 7983740B2 · Culver et al. · 2011 [cited by applicant]
US 7986342B2 · Yogesan et al. · 2011 [cited by applicant]
US 7986987B2 · Bazin et al. · 2011 [cited by applicant]
US 7996068B2 · Telischak et al. · 2011 [cited by applicant]
US 8000775B2 · Pogue et al. · 2011 [cited by applicant]
US 8005527B2 · Zelenchuk · 2011 [cited by applicant]
US 8026942B2 · Payonk et al. · 2011 [cited by applicant]
US 8031924B2 · Can et al. · 2011 [cited by applicant]
US 8039816B2 · Morishita et al. · 2011 [cited by applicant]
US 8041162B2 · Wang et al. · 2011 [cited by applicant]
US 8045153B2 · Mimura et al. · 2011 [cited by applicant]
US 8045263B2 · Yaroslavsky et al. · 2011 [cited by applicant]
US 8050735B2 · Feke et al. · 2011 [cited by applicant]
US 8055035B2 · Okugawa et al. · 2011 [cited by applicant]
US 8078243B2 · Ediger et al. · 2011 [cited by applicant]
US 8078263B2 · Zeman et al. · 2011 [cited by applicant]
US 8078264B2 · Basilion · 2011 [cited by applicant]
US 8078265B2 · Mahmood et al. · 2011 [cited by applicant]
US 8082024B2 · Alfano et al. · 2011 [cited by applicant]
US 8107696B2 · Pote et al. · 2012 [cited by applicant]
US 8108022B2 · Balberg et al. · 2012 [cited by applicant]
US 8118206B2 · Zand et al. · 2012 [cited by applicant]
US 8121671B2 · Hull et al. · 2012 [cited by applicant]
US 8125623B2 · Munger et al. · 2012 [cited by applicant]
US 8129105B2 · Zuckerman · 2012 [cited by applicant]
US 8131332B2 · Maynard et al. · 2012 [cited by applicant]
US 8131349B2 · Okawa et al. · 2012 [cited by applicant]
US 8135449B2 · Wilson et al. · 2012 [cited by applicant]
US 8139211B2 · Yaroslavsky et al. · 2012 [cited by applicant]
US 8140147B2 · Maynard et al. · 2012 [cited by applicant]
US 8145295B2 · Boyden et al. · 2012 [cited by applicant]
US 8149418B2 · Tearney et al. · 2012 [cited by applicant]
US 8157807B2 · Ferren et al. · 2012 [cited by applicant]
US 8158919B2 · Maeda et al. · 2012 [cited by applicant]
US 8160680B2 · Boyden et al. · 2012 [cited by applicant]
US 8180421B2 · Phillips · 2012 [cited by examiner]
US 8180436B2 · Boyden et al. · 2012 [cited by applicant]
US 8185180B2 · Diab et al. · 2012 [cited by applicant]
US 8188446B2 · Ohno · 2012 [cited by applicant]
US 8189201B2 · Haisch et al. · 2012 [cited by applicant]
US 8189887B2 · Kollias et al. · 2012 [cited by applicant]
US 8190231B2 · Miwa et al. · 2012 [cited by applicant]
US 8190242B2 · Demos et al. · 2012 [cited by applicant]
US 8204579B2 · Nielsen et al. · 2012 [cited by applicant]
US 8213005B2 · Masilamani et al. · 2012 [cited by applicant]
US 8218143B2 · Gupta · 2012 [cited by applicant]
US 8224427B2 · Kopriva · 2012 [cited by applicant]
US 8227766B2 · Chapman · 2012 [cited by applicant]
US 8228368B2 · Zhao et al. · 2012 [cited by applicant]
US 8229548B2 · Frangioni · 2012 [cited by applicant]
US 8231526B2 · Yabe et al. · 2012 [cited by applicant]
US 8238993B2 · Maynard et al. · 2012 [cited by applicant]
US 8243269B2 · Matousek et al. · 2012 [cited by applicant]
US 8246611B2 · Paithankar et al. · 2012 [cited by applicant]
US 8255040B2 · Goldman et al. · 2012 [cited by applicant]
US 8260010B2 · Chhibber et al. · 2012 [cited by applicant]
US 8270689B2 · Liang et al. · 2012 [cited by applicant]
US 8279275B2 · Gono et al. · 2012 [cited by applicant]
US 8280140B2 · Levenson et al. · 2012 [cited by applicant]
US 8280471B2 · Rainone et al. · 2012 [cited by applicant]
US 8285015B2 · Demos · 2012 [cited by applicant]
US 8285353B2 · Choi et al. · 2012 [cited by applicant]
US 8289522B2 · Tearney et al. · 2012 [cited by applicant]
US 8294081B2 · Rosenheimer et al. · 2012 [cited by applicant]
US 8295901B2 · Tobola et al. · 2012 [cited by applicant]
US 8311607B2 · Zelenchuk · 2012 [cited by applicant]
US 8320650B2 · Demos et al. · 2012 [cited by applicant]
US 8326404B2 · Zeng et al. · 2012 [cited by applicant]
US 8326406B2 · Ntziachristos et al. · 2012 [cited by applicant]
US 8330087B2 · Domenicali · 2012 [cited by applicant]
US 8332006B2 · Naganuma et al. · 2012 [cited by applicant]
US 8335550B2 · Segman · 2012 [cited by applicant]
US 8346329B2 · Xu et al. · 2013 [cited by applicant]
US 8351026B2 · Stern · 2013 [cited by applicant]
US 8351041B2 · Leveque et al. · 2013 [cited by applicant]
US 8358821B2 · Yamaguchi et al. · 2013 [cited by applicant]
US 8380268B2 · Georgakoudi et al. · 2013 [cited by applicant]
US 8385615B2 · Levenson et al. · 2013 [cited by applicant]
US 8391961B2 · Levenson et al. · 2013 [cited by applicant]
US 8403862B2 · Grinvald et al. · 2013 [cited by applicant]
US 8417324B2 · Mycek et al. · 2013 [cited by applicant]
US 8423127B2 · Mahmood et al. · 2013 [cited by applicant]
US 8452357B2 · Rebec et al. · 2013 [cited by applicant]
US 8452384B2 · Ince · 2013 [cited by applicant]
US 8463006B2 · Prokoski · 2013 [cited by applicant]
US 8467857B2 · Kim et al. · 2013 [cited by applicant]
US 8491120B2 · Kahn et al. · 2013 [cited by applicant]
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