Non-pyrogenic preparation comprising nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications

1. A preparation comprising at least one synthetic nanoparticle, the at least one synthetic nanoparticle comprising:

a crystallized mineral central part comprising predominantly an iron oxide, the central part having been produced by a living organism,

wherein the central part has at least one property selected in the group consisting of:

i) the central part is non-pyrogenic,

and

ii) the central part comprises less than 50% of organic material;

wherein the preparation does not comprise non-denatured proteins or is non-immunogenic or wherein the at least one synthetic nanoparticle comprises no non-denatured endotoxins.

2. The preparation according to claim 1 , wherein the central part does not contain any coating.

3. The preparation according to claim 1 , wherein the central part is surrounded by a coating comprising no material originating from the living organism.

4. The preparation according to claim 1 , wherein the living organism is a magnetotactic bacterium.

5. The preparation according to claim 1 , wherein the central part comprises maghemite and/or magnetite.

6. The preparation according to claim 1 , wherein the at least one synthetic nanoparticle further comprises proteins, and the proteins are non-denatured proteins.

7. The preparation according to claim 1 , wherein the at least one synthetic nanoparticle is prepared by a process comprising the steps of:

obtaining or starting from at least one natural nanoparticle produced by a living organism, the at least one natural nanoparticle comprising a crystallized mineral central part that comprises predominantly an iron oxide and an original surrounding coating that covers the central part; and

removing from the central part at least a portion of the original surrounding coating in a manner such that the central part is not associated with non-denatured proteins originating from the living organism that produced the central part.

8. A method for treating a tumor in an individual or animal, wherein a therapeutically active quantity of the preparation according to claim 1 is administered to the individual or animal.

9. A composition comprising the preparation as defined in claim 1 .

10. A medical device or drug comprising the preparation as defined in claim 1 .

11. A preparation comprising the synthetic nanoparticle obtained by the method comprising the following steps:

(i) from a preparation of nanoparticles synthesized by a living organism comprising a crystallized central part composed predominantly of an iron oxide and a biological surrounding coating, isolating the central part; and

(ii) optionally sterilizing the preparation, after step (i).