IP Library Granted Patent US 11,211,160
Granted Patent B2
US 11,211,160 · App. 17/200,563 · Granted Dec 28, 2021

Systems and methods of automatically processing electronic images across regions

Inventors: Razik Yousfi (New York, NY); Peter Schueffler (New York, NY); Thomas Fresneau (New York, NY); Alexander Tsema (New York, NY)
Assignee: Paige.AI, Inc.
G16H30/20G06K9/627G06N20/00G06T7/0012G16H10/60G16H30/40
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Quick Facts
Patent No.
US 11,211,160
App. No.
17/200,563
Granted
Dec 28, 2021
Kind
B2
Abstract

Systems and methods are disclosed for using an integrated computing platform to view and transfer digital pathology slides using artificial intelligence, the method including receiving at least one whole slide image in a cloud computing environment located in a first geographic region, the whole slide image depicting a medical sample associated with a patient, the patient being located in the first geographic region; storing the received whole slide image in a first encrypted bucket; applying artificial intelligence to perform a classification of the at least one whole slide image, the classification comprising steps to determine whether portions of the medical sample depicted in the whole slide image are healthy or diseased; based on the classification of the at least one whole slide image, generating metadata associated with the whole slide image; and storing the metadata in a second encrypted bucket.

Claims (67)

1. A computer-implemented method for using an integrated computing platform to view and transfer digital pathology slides using artificial intelligence, the method comprising:

receiving at least one whole slide image in a cloud computing environment located in a first geographic region, the whole slide image depicting a medical sample associated with a patient, the patient being located in the first geographic region;

storing the received whole slide image in a first encrypted bucket;

applying artificial intelligence to perform a classification of the at least one whole slide image, the classification comprising steps to determine whether portions of the medical sample depicted in the whole slide image are healthy or diseased;

based on the classification of the at least one whole slide image, generating metadata associated with the whole slide image; and

storing the metadata in a second encrypted bucket.

2. The method of claim 1 , further comprising:

receiving a request to transfer the at least one whole slide image to a second geographic region;

determining one or more rules associated with the second geographic region;

removing data from the whole slide image and/or the metadata based on the rules associated with the second geographic region to generate a modified whole slide image and modified metadata; and

providing the modified whole slide image and modified metadata for transfer to the second geographic region.

3. The method of claim 1 , further comprising:

receiving a request for the whole slide image from a client device;

determining whether the client device is located in the first geographic region;

in response to determining that the client device is located in the first geographic region, providing the whole slide image and the metadata to the client device; and

in response to determining that the client device is not located in the first geographic region, processing the whole slide image to determine a second whole slide image, and processing the metadata to produce modified metadata, the processing of the whole slide image and the processing of the metadata being based upon one or more rules associated with the first geographic region.

4. The method of claim 1 , wherein storing the received whole slide image further comprises performing automatic artificial-intelligence based ingestion of the received whole slide image.

5. The method of claim 1 , wherein personal health information, as defined by one or more rules associated with the first geographic region, is not permitted to leave the first geographic region.

6. The method of claim 1 , wherein applying artificial intelligence to perform a classification further comprises:

determining a heatmap based on the determination of whether portions of the medical sample depicted in the whole slide image are healthy or diseased; and

storing the heatmap in the second encrypted bucket.

7. The method of claim 1 , wherein generating metadata further comprises:

determining a heatmap, the heatmap comprising a graphical prediction of a likelihood of disease in the medical sample.

8. The method of claim 1 , wherein the applying of artificial intelligence to perform the classification is performed at least in part based on patient metadata associated with the patient.

9. A system for processing an electronic image corresponding to a specimen, the system comprising:

at least one memory storing instructions; and

at least one processor configured to execute the instructions to perform operations comprising:

receiving at least one whole slide image in a cloud computing environment located in a first geographic region, the whole slide image depicting a medical sample associated with a patient, the patient being located in the first geographic region;

storing the received whole slide image in a first encrypted bucket;

applying artificial intelligence to perform a classification of the at least one whole slide image, the classification comprising steps to determine whether portions of the medical sample depicted in the whole slide image are healthy or diseased;

based on the classification of the at least one whole slide image, generating metadata associated with the whole slide image; and

storing the metadata in a second encrypted bucket.

10. The system of claim 9 , the operations further comprising:

receiving a request to transfer the at least one whole slide image to a second geographic region;

determining one or more rules associated with the second geographic region;

removing data from the whole slide image and/or the metadata based on the rules associated with the second geographic region to generate a modified whole slide image and modified metadata; and

providing the modified whole slide image and modified metadata for transfer to the second geographic region.

11. The system of claim 9 , the operations further comprising:

receiving a request for the whole slide image from a client device;

determining whether the client device is located in the first geographic region;

in response to determining that the client device is located in the first geographic region, providing the whole slide image and the metadata to the client device; and

in response to determining that the client device is not located in the first geographic region, processing the whole slide image to determine a second whole slide image, and processing the metadata to produce modified metadata, the processing of the whole slide image and the processing of the metadata being based upon one or more rules associated with the first geographic region.

12. The system of claim 9 , wherein storing the received whole slide image further comprises performing automatic artificial-intelligence based ingestion of the received whole slide image.

13. The system of claim 9 , wherein personal health information, as defined by one or more rules associated with the first geographic region, is not permitted to leave the first geographic region.

14. The system of claim 9 , wherein applying artificial intelligence to perform a classification further comprises:

determining a heatmap based on the determination of whether portions of the medical sample depicted in the whole slide image are healthy or diseased; and

storing the heatmap in the second encrypted bucket.

15. The system of claim 9 , wherein generating metadata further comprises:

determining a heatmap, the heatmap comprising a graphical prediction of a likelihood of disease in the medical sample.

16. The system of claim 9 , wherein the applying of artificial intelligence to perform the classification is performed at least in part based on patient metadata associated with the patient.

17. A non-transitory computer readable medium storing instructions that, when executed by a processor, cause the processor to perform operations comprising:

receiving at least one whole slide image in a cloud computing environment located in a first geographic region, the whole slide image depicting a medical sample associated with a patient, the patient being located in the first geographic region;

storing the received whole slide image in a first encrypted bucket;

applying artificial intelligence to perform a classification of the at least one whole slide image, the classification comprising steps to determine whether portions of the medical sample depicted in the whole slide image are healthy or diseased;

based on the classification of the at least one whole slide image, generating metadata associated with the whole slide image; and

storing the metadata in a second encrypted bucket.

18. The computer-readable medium of claim 17 , the operations further comprising:

receiving a request to transfer the at least one whole slide image to a second geographic region;

determining one or more rules associated with the second geographic region;

removing data from the whole slide image and/or the metadata based on the rules associated with the second geographic region to generate a modified whole slide image and modified metadata; and

providing the modified whole slide image and modified metadata for transfer to the second geographic region.

19. The computer-readable medium of claim 17 , the operations further comprising:

receiving a request for the whole slide image from a client device;

determining whether the client device is located in the first geographic region;

in response to determining that the client device is located in the first geographic region, providing the whole slide image and the metadata to the client device; and

in response to determining that the client device is not located in the first geographic region, processing the whole slide image to determine a second whole slide image, and processing the metadata to produce modified metadata, the processing of the whole slide image and the processing of the metadata being based upon one or more rules associated with the first geographic region.

20. The computer-readable medium of claim 17 , wherein storing the received whole slide image further comprises performing automatic artificial-intelligence based ingestion of the received whole slide image.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded May 14, 2026
From: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
To: PAIGE.AI, INC.
Reel/Frame 075589/0752 →
SECURITY INTEREST Recorded Oct 21, 2025
From: PAIGE.AI, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 073216/0876 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 17, 2021
From: YOUSFI, RAZIK; SCHUEFFLER, PETER; FRESNEAU, THOMAS; TSEMA, ALEXANDER
To: PAIGE.AI, INC.
Reel/Frame 055615/0601 →
Continuity (2)
Provisional Application 62989095 · Mar 13, 2020
Related Publication 20210287778A1 · Sep 16, 2021
Cited By (2)
US 12,475,564 US 12,573,194