IP Library › Granted Patent US 12,622,745
Granted Patent B2
US 12,622,745 · App. 17/201,166 · Granted May 12, 2026

Systems and methods for sealing cored or punctured tissue using inflatable balloon

Inventors: William Cohn (Bellaire, TX); Terry Daglow (Houston, TX); Matthew Kuhn (Houston, TX); Steven Nguyen (Cypress, TX)
Assignee: Prana Thoracic, Inc.
A61B18/1477A61B2018/0022A61B2018/00541A61B2018/00577A61B2018/0063A61B2018/00714
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Quick Facts
Patent No.
US 12,622,745
App. No.
17/201,166
Granted
May 12, 2026
Kind
B2
Abstract

Systems and methods for sealing tissue sites may comprise coring tissue at a target site such that a tissue core is removed from the target site thereby creating a core cavity at the target site and causing sealing of at least a portion of the target site.

Claims (49)

1 . A method for sealing tissue at a target site, the method comprising:

anchoring a distal end of an anchor device to a portion of the target site;

coring tissue at the target site to remove a section of cored tissue thereby creating a cored cavity;

disposing, after removing the section of cored tissue, a sealing device across an opening of the cored cavity;

causing at least a portion of the sealing device to seal across the opening of the cored cavity;

delivering, after at least the portion of the cored cavity is sealed, a fill material to the target site, the fill material including autologous blood configured to clot after a predetermined period of time;

holding the sealing device in place, via the anchor device, for the predetermined period of time to allow the autologous blood to clot at the target site; and

spacing, after the predetermined period of time, the sealing device from the target site while leaving the fill material at the target site.

2 . The method of claim 1 , wherein the target site comprises tissue of a lung.

3 . The method of claim 1 , wherein the sealing device includes an inflatable balloon, and causing the portion of the sealing device to seal across the opening of the cored cavity includes inflating the inflatable balloon using a fluid.

4 . The method of claim 1 , wherein the sealing device includes an inflatable balloon, and causing the portion of the sealing device to seal across the opening of the cored cavity includes inflating the inflatable balloon to at least a radius of the cored cavity.

5 . The method of claim 1 , wherein the target site comprises at least a portion of a lung, the method further comprising causing the lung to collapse prior to disposing the sealing device across the opening of the cored cavity.

6 . The method of claim 1 , wherein the target site comprises at least a portion of a lung, the method further comprising allowing the lung to ventilate while the sealing device is sealing the opening of the cored cavity.

7 . The method of claim 1 , wherein a bio-adhesive is disposed on a surface of the sealing device such that the bio-adhesive contacts a wall of the cored cavity when the sealing device is caused to seal across the opening of the cored cavity.

8 . The method of claim 1 , wherein the sealing device is configured to deliver radiofrequency (RF) energy to at least a portion of a wall of the cored cavity.

9 . The method of claim 1 , wherein the sealing device includes an inflatable balloon, and causing the portion of the sealing device to seal across the opening of the cored cavity includes inflating the inflatable balloon, the method further comprising:

deflating the inflatable balloon for removal from the cored cavity.

10 . A method for sealing tissue at a target site, the method comprising:

disposing a port adjacent to tissue;

anchoring a distal end of an anchor device to a portion of the target site;

removing, using a tissue resection device, a section of cored tissue to create a cored tissue cavity;

disposing, after removing the section of cored tissue, a sealing device through the port and adjacent to the cored tissue cavity while remaining outside of the cored tissue cavity;

causing at least a portion of the sealing device to seal across an opening of the cored tissue cavity;

delivering, after causing the portion of the sealing device to seal across the opening of the cored tissue cavity, a fill material to the target site, the fill material including autologous blood configured to clot after a predetermined period of time; and

holding the sealing device in place, via the anchor device, for the predetermined period of time to allow the autologous blood to clot at the target site.

11 . The method of claim 10 , wherein the cored tissue cavity is formed in a lung.

12 . The method of claim 10 , wherein the sealing device includes an inflatable balloon, and causing the portion of the sealing device to seal across the opening of the cored tissue cavity includes inflating the inflatable balloon using a fluid.

13 . The method of claim 10 , wherein the sealing device includes an inflatable balloon, and causing the portion of the sealing device to seal across the opening of the cored tissue cavity includes inflating the inflatable balloon to at least radius of the cored tissue cavity.

14 . The method of claim 10 , wherein the cored tissue cavity is disposed in a lung, the method further comprising causing the lung to collapse prior to disposing the sealing device adjacent to the cored tissue cavity.

15 . The method of claim 10 , wherein the cored tissue cavity is disposed in a lung, the method further comprising allowing the lung to ventilate while the sealing device is sealing across the opening of the cored tissue cavity.

16 . The method of claim 10 , wherein the sealing device includes an inflatable balloon, and causing the portion of the sealing device to seal across the opening of the cored tissue cavity includes inflating the inflatable balloon, the method further comprising:

deflating the inflatable balloon for removal from the cored tissue cavity.

17 . The method of claim 10 , further comprising removing the sealing device from the cored tissue cavity.

18 . A method for sealing tissue at a target site, the method comprising:

anchoring a distal end of an anchor device to a portion of the target site;

coring, using a coring device including a pair of electrodes, a tissue at a target site to remove a section of cored tissue thereby creating a cored cavity;

disposing, after removing the coring device and the section of cored tissue, a sealing device adjacent to or within the cored cavity;

causing at least a portion of the sealing device to abut a portion of the cored cavity to seal at least the portion of the cored cavity to form a sealed cavity;

delivering, using a fill material delivery device, a fill material to the sealed cavity, the fill material including autologous blood configured to clot after a predetermined period of time; and

holding the sealing device in place, via the anchor device, for the predetermined period of time to allow the autologous blood to clot at the target site.

19 . The method of claim 18 , wherein the target site comprises tissue of a lung.

20 . The method of claim 18 , wherein the sealing device includes an inflatable balloon, and causing the portion of the sealing device to seal at least the portion of the cored cavity includes inflating the inflatable balloon using a fluid.

21 . The method of claim 18 , wherein a bio-adhesive is disposed on a surface of the sealing device such that the bio-adhesive contacts a wall of the cored cavity when the sealing device is caused to abut the portion of the cored cavity.

22 . The method of claim 18 , wherein the sealing device is configured to deliver radiofrequency (RF) energy to at least a portion of a wall of the cored cavity.

23 . The method of claim 18 , wherein the sealing device includes an inflatable balloon, and causing the sealing device to seal at least the portion of the cored cavity includes inflating the inflatable balloon to at least a radius of the cored cavity.

24 . The method of claim 18 , wherein the target site comprises at least a portion of a lung, the method further comprising causing the lung to collapse prior to disposing the sealing device adjacent to the cored cavity.

25 . The method of claim 18 , wherein the target site comprises at least a portion of a lung, the method further comprising allowing the lung to ventilate while the sealing device is sealing at least the portion of the cored cavity.

26 . The method of claim 18 , wherein a bio-adhesive is disposed on a surface of the sealing device such that the bio-adhesive contacts a wall of the cored cavity when the sealing device is caused to seal at least the portion of the cored cavity.

27 . The method of claim 10 , wherein the sealing device is configured to deliver radiofrequency (RF) energy to at least a portion of a wall of the cored tissue cavity.

Assignments (2)
NUNC PRO TUNC ASSIGNMENT Recorded Jan 29, 2026
From: COHN, WILLIAM; DAGLOW, TERRY; KUHN, MATTHEW; NGUYEN, STEVEN
To: ETHICON, INC.
Reel/Frame 073633/0632 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 18, 2022
From: ETHICON, INC.
To: PRANA THORACIC, INC.
Reel/Frame 061820/0056 →
Continuity (2)
Provisional Application 63017734 · Apr 30, 2020
Related Publication 20210338316A1 · Nov 4, 2021
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