Synergistic dietary supplement compositions for the prevention, treatment or control of inflammatory disorders
A method for treating an inflammation, arthritis, or a joint disease in a patient in need thereof, comprising administering to the patient an herbal composition, where the herbal composition includes a therapeutically effective amount of an extract of Terminalia chebula ; a therapeutically effective amount of an extract of Curcuma longa ; and a therapeutically effective amount of a non-acidic, water-immiscible organic solvent extract of a Boswellia serrata resin.
1. A method for treating an inflammation, arthritis, or a joint disease in a patient in need thereof, comprising administering to the patient an effective amount of an herbal composition, wherein the herbal composition comprises:
from 20% by weight to 75% by weight of an extract of Terminalia chebula;
from 10% by weight to 40% by weight of an extract of Curcuma longa ; and
from 10% by weight to 40% by weight of a non-acidic, water-immiscible organic solvent extract of a Boswellia serrata resin,
based on the total weight of the Terminalia chebula, Curcuma longa , and Boswellia serrata extracts.
2. The method according to claim 1 , wherein the non-acidic, water-immiscible organic solvent extract of the Boswellia serrata resin is a product obtained by a process comprising:
extracting Boswellia serrata gum resin with a water-immiscible organic solvent to obtain an organic solution;
extracting the organic solution with aqueous alkali to remove boswellic acids from the organic solution; and
removing the water-immiscible organic solvent from the organic solution to obtain an organic solvent extract.
3. The method according to claim 1 , wherein the non-acidic, water-immiscible organic solvent extract of the Boswellia serrata resin is a product obtained by a process comprising:
extracting Boswellia serrata gum resin with a water-immiscible organic solvent to obtain an organic solution;
extracting the organic solution with aqueous alkali to remove boswellic acids from the organic solution;
removing the water-immiscible organic solvent from the organic solution to obtain an organic solvent extract; and
removing volatile components from the organic solvent extract under vacuum to obtain said non-acidic, water-immiscible organic solvent extract.
4. The method according to claim 1 , wherein the herbal composition further comprises at least one ingredient selected from the group consisting of:
plant derived anti-inflammatory agents,
pharmaceutically, nutraceutically, or dietetically acceptable carriers, and
pharmaceutically, nutraceutically, or dietetically acceptable excipients.
5. The method according to claim 4 , wherein the carriers and excipients are selected from the group consisting of surfactants, binders, diluents, disintegrants, lubricants, preservatives, stabilizers, buffers, suspensions, and drug delivery systems.
6. The method according to claim 1 , wherein:
the extract of Terminalia chebula is prepared from dried fruits of Terminalia chebula;
the extract of Curcuma longa is prepared from dried rhizomes of Curcuma longa ; and
the non-acidic, water-immiscible organic solvent extract of the Boswellia serrata resin is prepared from a gum resin of Boswellia serrata.
7. The method according to claim 1 , wherein the herbal composition further comprises:
from 0% by weight to 20% by weight of a Boswellia serrata extract which contains at least 5% 3-O-acetyl-11-keto-β-boswellic acid (AKBA),
based on the total weight of the Terminalia chebula, Curcuma longa , and Boswellia serrata extracts.
8. The method according to claim 1 , wherein the herbal composition comprises:
from 25% by weight to 65% by weight of the extract of Terminalia chebula;
from 12% by weight to 30% by weight of the extract of Curcuma longa ; and
from 12% by weight to 30% by weight of the non-acidic, water-immiscible organic solvent extract of the Boswellia serrata resin,
based on the weight of the composition.
9. The method according to claim 1 , wherein the herbal composition comprises:
from 25% by weight to 45% by weight of the extract of Terminalia chebula;
from 15% by weight to 25% by weight of the extract of Curcuma longa;
from 15% by weight to 25% by weight of the non-acidic, water-immiscible organic solvent extract of the Boswellia serrata resin, and
from 15% by weight to 25% by weight of a Boswellia serrata extract which contains at least 5% 3-O-acetyl-11-keto-β-boswellic acid (AKBA),
based on the weight of the composition.
10. The method according to claim 1 , wherein the extracts of Terminalia chebula, Curcuma longa and Boswellia serrata are aqueous, alcoholic or hydroalcoholic extracts.
11. The method according to claim 1 , wherein the composition is administered to the patient orally, topically, transdermally, or parenterally.
12. A method for treating a joint disease in a patient in need thereof, wherein the joint disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, osteoarthritis, refractory rheumatoid arthritis, chronic non-rheumatoid arthritis, osteoporosis/bone resorption, collagen degradation, gouty arthritis, lupus, juvenile arthritis, joint pain, or a combination thereof, wherein the method comprises administering to the patient an effective amount of an herbal composition, wherein the herbal composition comprises:
from 20% by weight to 75% by weight of an extract of Terminalia chebula;
from 10% by weight to 40% by weight of an extract of Curcuma longa ; and
from 10% by weight to 40% by weight of a non-acidic, water-immiscible organic solvent extract of a Boswellia serrata resin,
based on the total weight of the Terminalia chebula, Curcuma longa , and Boswellia serrata extracts.
13. The method according to claim 12 , wherein the herbal composition comprises:
from 20% by weight to 75% by weight of the extract of Terminalia chebula;
from 15% by weight to 40% by weight of the extract of Curcuma longa ; and
from 10% by weight to 40% by weight of the non-acidic, water-immiscible organic solvent extract of the Boswellia serrata resin; and
from 0% by weight to 20% by weight of a Boswellia serrata extract which contains at least 5% 3-O-acetyl-11-keto-β-boswellic acid (AKBA),
based on the total weight of the Terminalia chebula, Curcuma longa , and Boswellia serrata extracts.
14. A method for treating a patient having an inflammation, arthritis, or a joint disease, comprising administering to the patient an effective amount of an herbal composition, wherein the herbal composition comprises:
a therapeutically effective amount of an extract of Terminalia chebula;
a therapeutically effective amount of an extract of Curcuma longa ; and
a therapeutically effective amount of a non-acidic, water-immiscible organic solvent extract of a Boswellia serrata resin.
15. A method according to claim 14 , wherein the herbal composition is administered to a patient having a joint disease, wherein the joint disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, osteoarthritis, refractory rheumatoid arthritis, chronic non-rheumatoid arthritis, osteoporosis/bone resorption, collagen degradation, gouty arthritis, lupus, juvenile arthritis, joint pain, and a combination thereof.
16. The method according to claim 15 , wherein the herbal composition further comprises from 0% by weight to 20% by weight of a Boswellia serrata extract which contains at least 5% 3-O-acetyl-11-keto-β-boswellic acid (AKBA), based on the total weight of the Terminalia chebula, Curcuma longa , and Boswellia serrata extracts.