IP Library Granted Patent US 11,758,933
Granted Patent B2
US 11,758,933 · App. 17/211,144 · Granted Sep 19, 2023

High intensity sweeteners

Inventors: Andrew Patron (San Marcos, CA); Rama Manam (San Diego, CA); Justin Colquitt (San Diego, CA); Nicole Servant (San Diego, CA); Chris Edano Noriega (San Diego, CA); Jeffrey R. Hammaker (San Diego, CA); Nicole Gonsalves (San Diego, CA); Tanya Ditschun (San Diego, CA)
Assignee: Firmenich Incorporated
A23L27/204A23L2/385A23L2/52A23L2/60A23L27/00A23L27/36A23P10/20C07J9/00C07J17/005A23V2002/00
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Quick Facts
Patent No.
US 11,758,933
App. No.
17/211,144
Granted
Sep 19, 2023
Kind
B2
Abstract

Disclosed herein are compounds having structural Formula (I), or salts thereof. These compounds are useful as sweet tasting agents and/or sweetness enhancers. Also disclosed are compositions comprising the present compounds and methods of increasing the sweet taste of ingestible compositions. Furthermore, methods for preparing the compounds are also disclosed.

Claims (43)

1. A composition, comprising a compound having the structure:

or a salt thereof, wherein the composition comprises greater than 70% by weight of the compound.

2. The composition of claim 1 , comprising less than 1% by weight of Mogroside III E .

3. The composition of claim 1 , comprising less than 0.3% by weight of 11-oxo-Mogroside III E .

4. The composition of claim 1 , comprising less than 1% by weight of all isomers of Mogroside I, Mogroside II, and Mogroside III.

5. The composition of claim 1 , comprising less than 1% by weight of 11-oxo-mogrol.

6. The composition of claim 1 , wherein the compound is in amorphous form.

7. The composition of claim 1 , wherein the compound is coating a solid carrier.

8. The composition of claim 7 , wherein the solid carrier are particles selected from the group consisting of lactose, cellulose, microcrystalline cellulose, modified food starch, gum Arabic, maltodextrin, modified corn starch, dextrose, xantham gum, carboxymethylcellulose, cellulose gel, cellulose gum, sodium caseinate, carrageenan, and combinations thereof.

9. The composition of claim 6 , wherein the composition is in particulate form.

10. The composition of claim 9 , wherein the composition has an average particle size between 50 μm and 300 μm.

11. A composition, comprising solid particles of the composition of claim 1 and a liquid carrier.

12. The composition of claim 11 , wherein the solid particles are suspended in the liquid carrier.

13. The composition of claim 11 , wherein the liquid carrier is selected from water, ethanol, propylene glycol, triacetine, medium chain triglycerides, glycerin, and combinations thereof.

14. The composition of claim 11 , wherein the liquid carrier is water.

15. The composition of claim 1 , comprising one or more additional compounds selected from the group consisting of steviosides, rebaudiosides, glycyrrhizic acid, glycyrrhizin, GAMG (glycyrrhetinic acid monoglucuronide), thaumatin, monellin, brazzein, curculin, mabinlin, pentadin, monatin, abrusosides, albiziasaponins, Baiyunoside, bryoside, cussoracosides, cyclocarioside, mukurozioside, osladin, periandrin, phlomisoside, Polypodosides, pterocaryosides, rubusosides, telosmosides, selligueain A, hernandulcin, phlorizin, trilobatin, phylodulcin, dulcoside A, gaudichaudioside A, and combinations thereof.

16. A composition, comprising a bulking agent and a compound having the structure:

or a salt thereof, wherein the composition comprises greater than 30% by weight of the bulking agent.

17. The composition of claim 16 , comprising between 0.5% and 5% by weight of the compound.

18. The composition of claim 16 , comprising greater than 50% by weight of the bulking agent.

19. The composition of claim 16 , comprising greater than 70% by weight of the bulking agent.

20. The composition of claim 16 , comprising greater than 90% by weight of the bulking agent.

21. The composition of claim 16 , wherein the bulking agent is selected from the group consisting of maltodextrin, dextro-maltodextrin blends, corn syrup solids, sucrose, fructose, glucose, invert sugar, sorbitol, xylose, ribulose, mannose, mannitol, galactitol, lactitol, isomalt, maltose, tagatose, lactose, inulin, glycerol, propylene glycol, polydextrose, fructooligosaccharides, cellulose, cellulose derivatives, erythritol, and combinations thereof.

22. The composition of claim 16 , wherein the bulking agent is selected from maltodextrin, lactose, erythritol, and mannitol.

23. The composition of claim 16 , wherein the bulking agent is in particulate form and the compound is present as a coating on the particles.

24. The composition of claim 16 , wherein the composition is in particulate form.

25. The composition of claim 23 , wherein the average particle size is between 200 μm and 2 mm.

26. The composition of claim 23 , wherein the average particle size is between 200 μm and 500 μm.

27. The composition of claim 23 , wherein the average particle size is between 500 μm and 700 μm.

28. The composition of claim 23 , wherein the average particle size is between 800 μm and 1.5 mm.

29. The composition of claim 16 , comprising one or more additional compounds selected from the group consisting of steviosides, rebaudiosides, glycyrrhizic acid, glycyrrhizin, glycyrrhetinic acid monoglucuronide, thaumatin, monellin, brazzein, curculin, mabinlin, pentadin, monatin, abrusosides, albiziasaponins, Baiyunoside, bryoside, cussoracosides, cyclocarioside, mukurozioside, osladin, periandrin, phlomisoside, Polypodosides, pterocaryosides, rubusosides, telosmosides, selligueain A, hernandulcin, phlorizin, trilobatin, phylodulcin, dulcoside A, gaudichaudioside A, and combinations thereof.

30. A tabletop sweetener product, comprising a packet containing a composition of claim 16 .

31. The product of claim 30 , wherein the packet is a single serving packet.

32. A flavoring concentrate, comprising a flavoring agent and a compound having the structure:

or a salt thereof, wherein the compound is at a concentration greater than 0.1% by weight.

33. The concentrate of claim 32 , wherein the flavoring agent is an artificial flavoring ingredient.

34. The concentrate of claim 32 , wherein the flavoring agent is a natural flavoring ingredient.

35. The concentrate of claim 32 , wherein the compound is at a concentration greater than 0.5% by weight.

36. The concentrate of claim 32 , wherein the compound is at a concentration greater than 1% by weight.

37. The concentrate of claim 32 , wherein the concentrate is a liquid.

38. The concentrate of claim 32 , wherein the concentrate is a solution.

39. The concentrate of claim 32 , wherein the concentrate is a solid.

40. The concentrate of claim 32 , wherein the compound is present in a concentration that is at least 2 times a concentration of the compound in a ready-to-use food or beverage product.

Assignments (4)
CORRECTIVE ASSIGNMENT TO CORRECT THE 6TH INVENTOR'S NAME PREVIOUSLY RECORDED AT REEL: 064362 FRAME: 0503. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Aug 14, 2023
From: PATRON, ANDREW; MANAM, RAMA; COLQUITT, JUSTIN; SERVANT, NICOLE; NORIEGA, CHRIS EDANO; HAMMAKER, JEFFREY R.; GONSALVES, NICOLE
To: SENOMYX, INC.
Reel/Frame 064585/0093 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 2, 2023
From: DITSCHUN, TANYA
To: FIRMENICH INCORPORATED
Reel/Frame 064475/0892 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 24, 2023
From: PATRON, ANDREW; MANAM, RAMA; COLQUITT, JUSTIN; SERVANT, NICOLE; NORIEGA, CHRIS EDANO; HAMMAKER, JEFFERY R.; GONSALVES, NICOLE
To: SENOMYX, INC.
Reel/Frame 064362/0503 →
MERGER AND CHANGE OF NAME Recorded Jul 24, 2023
From: SENOMYX, INC.; FIRMENICH INCORPORATED
To: FIRMENICH INCORPORATED
Reel/Frame 064368/0966 →
Continuity (3)
Continuation 15336579 · Oct 27, 2016
Provisional Application 62248206 · Oct 29, 2015
Related Publication 20210227863A1 · Jul 29, 2021
Cited By (3)
US 12,286,661 US 12,338,476 US 12,428,662