Crystalline epinephrine malonate salt
Described herein are epinephrine salts, specifically the epinephrine malonate salt; the epinephrine malonate salt in crystalline form; a pharmaceutical composition comprising epinephrine malonate; a sublingual or buccal pharmaceutical composition comprising epinephrine malonate in crystalline form; and a method for treating a patient comprising administering a pharmaceutical composition of epinephrine malonate in crystalline form.
1. A method for manufacturing an epinephrine malonate salt, said method comprising:
adding malonic acid to a solution comprising epinephrine and a solvent;
stirring the solution; and
precipitating the epinephrine malonate salt out of solution.
2. The method of claim 1 , further comprising filtering the precipitate.
3. The method of claim 2 , further comprising drying the precipitate.
4. The method of claim 1 , wherein malonic acid is added at a ratio of about 0.01:1 to 3:1 relative to epinephrine.
5. The method of claim 1 , wherein the solvent is selected from the group consisting of methanol, ethanol, n-propanol, iso-propanol, n-butanol, sec-butanol, tert-butanol, n-pentanol, 2-methyl-butanol, 3-methyl-butanol, and hexanol.
6. The method of claim 5 , wherein the solvent is ethanol.
7. A method of treating a patient suffering from an allergic condition, said method comprising:
administering a pharmaceutically effective amount of epinephrine malonate to the patient.
8. The method of claim 7 , wherein the epinephrine malonate is administered orally, rectally, intragastrically, topically, intracranially, intranasally, or parenterally.
9. The method of claim 7 , wherein the epinephrine malonate is administered via a buccal or sublingual tablet.
10. The method of claim 7 , wherein the allergic condition is selected from the group consisting of anaphylaxis, asthma, or bronchial asthma.
11. The method of claim 10 , wherein the allergic condition is anaphylaxis.