Comprehensive fixed pattern noise cancellation

1. A digital imaging method for use with an endoscope in ambient light deficient environments comprising:

actuating an emitter to emit a plurality of pulses of electromagnetic radiation to cause illumination within the light deficient environment;

pulsing the emitter at a predetermined interval corresponding to a sensing interval of a pixel array; and

sensing reflected electromagnetic radiation from a pulse with the pixel array to create an image frame in a plurality of cycles, each cycle including an integration period of the pixel array, wherein a duration of the integration period is variable from cycle to cycle in the plurality of cycles wherein said pixel array is actuated at a sensing interval that corresponds to the pulse interval of said emitter;

stopping the emitter from pulsing for a single iteration;

creating a dark frame by sensing the pixel array while the emitter is not pulsing a pulse;

creating one or more reference frames, using said dark frame, for use in removing fixed pattern noise;

removing fixed pattern noise from the image frame by subtracting stored reference data; and

creating a stream of images by combining a plurality of image frames to form a video stream;

wherein the method further comprises computing reference data for a particular integration duration by interpolating between two or more dark reference buffers established at two or more different integration times having two or more different duration lengths.

2. The method of claim 1 ,

wherein one or more dark frames are created from one or more sensing of the pixel array while the emitter is not issuing electromagnetic energy, and

wherein the one or more dark frames are created, interspersed within the image frames.

3. The method of claim 1 , wherein said one or more reference frames are created upon startup of a system comprising a laser emitter and pixel array and stored within memory associated with the system.

4. The method of claim 3 , wherein a plurality of reference frames may be established at different exposure times.

5. The method of claim 1 , further comprising enhancing the precision of the one or more reference frames with continued sampling of subsequent single dark frames.

6. The method of claim 5 , further comprising enhancing the precision of an existing reference frame by factoring in subsequent dark frame data, using exponential smoothing.

7. The method of claim 1 , wherein each image frame is enhanced before being integrated into the video stream.

8. The method in claim 7 , wherein the method further comprises subtracting data from a single dark reference buffer from an image frame.

9. The method of claim 1 , wherein the method further comprises subtracting said reference data from an image frame.

10. The method of claim 1 , wherein the emitter is a laser to emit a laser pulse of a wavelength of electromagnetic radiation to cause illumination within the light deficient environment.

11. The method of claim 1 , wherein the emitter is an LED emitter to emit an LED pulse of a wavelength of electromagnetic radiation to cause illumination within the light deficient environment.

12. A system for digital imaging system for use in ambient light deficient environments comprising:

one or more processors;

one or more memory devices operably coupled to the one or more processors and storing executable and operational data, the executable and operational data effective to cause the one or more processors to:

actuate a laser emitter to emit a plurality of pulses of electromagnetic radiation to cause illumination within the light deficient environment;

pulse the laser emitter at a predetermined interval corresponding to a sensing interval of a pixel array;

sense reflected electromagnetic radiation from the pulse with the pixel array to create an image frame in a plurality of cycles, wherein each cycle in the plurality of cycles includes an integration time of the pixel array, wherein a duration of the integration time is variable from cycle to cycle in the plurality of cycles, wherein said the pixel array is actuated at a sensing interval that corresponds to the pulse interval of said laser emitter;

stop the emitter from pulsing for a single iteration;

sense the pixel array while the emitter is not pulsing a pulse to create a dark frame;

create one or more reference frames, using said dark frame, for use in removing fixed pattern noise;

remove fixed pattern noise from an image frame by subtracting values derived from one or more dark reference frames; and

create a stream of images by combining a plurality of image frames to form a video stream;

wherein the executable and operational data is effective to cause the one or more processors to compute the reference data for a particular integration duration by interpolating between two or more dark reference buffers established at two or more different integration times having two or more different duration lengths.

13. The system of claim 12 ,

wherein one or more dark frames are created from one or more sensing of the pixel array while the emitter is not issuing electromagnetic energy, and

wherein the one or more dark frames are created, interspersed within the image frames.

14. The system of claim 12 , wherein said one or more reference frames are created upon startup of a system comprising the laser emitter and pixel array and stored within memory associated with the system.

15. The system of claim 14 , wherein a plurality of reference frames may be established at different exposure times.

16. The system of claim 12 , wherein the executable and operational data is effective to cause the one or more processors to enhance the precision of the one or more reference frames with continued sampling of subsequent single dark frames.

17. The system of claim 16 , wherein the executable and operational data effective to cause the one or more processors to enhance the precision of an existing reference frames by factoring in subsequent dark frame data, using exponential smoothing.

18. The system of claim 12 , wherein each image frame is enhanced before being integrated into the video stream.

19. The system of claim 18 , wherein the executable and operational data is effective to cause the one or more processors to subtract data from a single dark reference buffer from an image frame.

20. The system of claim 12 , wherein the executable and operational data is effective to cause the one or more processors to subtract said reference data from an image frame.