IP Library Patent Application 17222419
Patent Application
App. No. 17/222,419

COMPOSITIONS AND METHODS FOR POST-OPERATIVE OCULAR CARE

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Quick Facts
Patent No.
US None
App. No.
17/222,419
Abstract

Provided herein are certain preservative-free ophthalmic formulations for post-operative ocular care.

Claims (32)

1 . A method for treating an ocular condition of an eye, comprising administering a pharmaceutical composition at, in, or around the eye via a delivery device and per a predetermined dosing regimen, wherein:

the pharmaceutical composition is free of preservatives;

the pharmaceutical composition comprises one of:

(1) prednisolone PO 4 about 1%, moxifloxacin HCl about 0.5%, and bromfenac about 0.075%;

(2) prednisolone PO 4 about 1% and moxifloxacin HCl about 0.5%;

(3) moxifloxacin HCl about 0.5% and bromfenac about 0.075%;

(4) difluprednate about 0.05%, moxifloxacin HCl about 0.5%, and bromfenac about 0.075%;

wherein these percentages are with respect to weight per volume; and

the ocular condition is care after cataract surgery, care after LASIK surgery, care for a retina of the eye after cataract surgery, care for a retina of the eye after retina surgery, in preparation for an intraocular procedure, or during the intraocular procedure.

2 . The method of claim 1 , wherein the delivery device is an eye dropper.

3 . The method of claim 2 , wherein the eye dropper is a multidose eye dropper.

4 . The method of claim 3 , wherein the multidose eye dropper is (i) a dropper bottle for dispensing predetermined metered quantities of liquid, the dropper bottle comprising a non-return position preventing the liquid from flowing back into the dropper bottle; or (ii) an Ophthalmic Squeeze Dispenser (OSD) comprising a sealing closure member that closes a dispenser orifice when the liquid present near the dispenser orifice is at a pressure less than a predetermined threshold.

5 . The method of claim 1 , wherein the predetermined dosing regimen is once per day, twice per day, three times per day, once every other day, once per week, once every other week, or once monthly.

6 . The method of claim 1 , wherein the pharmaceutical composition comprises prednisolone PO 4 about 1%, moxifloxacin HCl about 0.5%, and bromfenac about 0.075%.

7 . The method of claim 1 , wherein the pharmaceutical composition comprises prednisolone PO 4 about 1% and moxifloxacin HCl about 0.5%.

8 . The method of claim 1 , wherein the pharmaceutical composition comprises moxifloxacin HCl about 0.5% and bromfenac about 0.075%.

9 . The method of claim 1 , wherein the pharmaceutical composition comprises difluprednate about 0.05%, moxifloxacin HCl about 0.5%, and bromfenac about 0.075%.

10 . A method for treating an ocular condition of an eye, comprising administering a pharmaceutical composition at, in, or around the eye via a delivery device and per a predetermined dosing regimen; wherein the pharmaceutical composition comprises at least two active pharmaceutical ingredients compounded and stored in communication with each other; wherein the pharmaceutical composition is free of preservatives; wherein the method is more effective as compared against a preexisting method; wherein the preexisting method administers the at least two active pharmaceutical ingredients from at least two separate and different containers; and wherein the pharmaceutical composition comprises one of:

(1) prednisolone PO 4 about 1%, moxifloxacin HCl about 0.5%, and bromfenac about 0.075%;

(2) prednisolone PO 4 about 1% and moxifloxacin HCl about 0.5%;

(3) moxifloxacin HCl about 0.5% and bromfenac about 0.075%;

(4) difluprednate about 0.05%, moxifloxacin HCl about 0.5%, and bromfenac about 0.075%;

wherein these percentages are with respect to weight per volume.

11 . The method of claim 10 , wherein the ocular condition is one or more of: care after cataract surgery, care after LASIK surgery, care for a retina of the eye after cataract surgery, care for a retina of the eye after retina surgery, in preparation for an intraocular procure, or during an intraocular procedure.

12 . The method of claim 10 , wherein the delivery device is an eye dropper.

13 . The method of claim 12 , wherein the eye dropper is a multidose eye dropper.

14 . The method of claim 13 , wherein the multidose eye dropper is (i) a dropper bottle for dispensing predetermined metered quantities of liquid, the dropper bottle comprising a non-return position preventing the liquid from flowing back into the dropper bottle; or (ii) an Ophthalmic Squeeze Dispenser (OSD) comprising a sealing closure member that closes a dispenser orifice when the liquid present near the dispenser orifice is at a pressure less than a predetermined threshold.

15 . The method of claim 10 , wherein the predetermined dosing regimen is once per day, twice per day, three times per day, once every other day, once per week, once every other week, or once monthly.

16 . The method of claim 10 , wherein the pharmaceutical composition comprises prednisolone PO 4 about 1%, moxifloxacin HCl about 0.5%, and bromfenac about 0.075%.

17 . The method of claim 10 , wherein the pharmaceutical composition comprises prednisolone PO 4 about 1% and moxifloxacin HCl about 0.5%.

18 . The method of claim 10 , wherein the pharmaceutical composition comprises moxifloxacin HCl about 0.5% and bromfenac about 0.075%.

19 . The method of claim 10 , wherein the pharmaceutical composition comprises difluprednate about 0.05%, moxifloxacin HCl about 0.5%, and bromfenac about 0.075%.

Assignments (2)
SECURITY INTEREST Recorded Dec 17, 2025
From: OCULAR SCIENCE, INC.
To: CHICAGO ATLANTIC ADMIN, LLC
Reel/Frame 073251/0162 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 18, 2021
From: SAMPIETRO, ANTHONY; GOLDBERG, DAMIEN; FROST, AMY; HOLDORF, BRIAN; MAH, FRANCIS
To: OCULAR SCIENCE, INC.
Reel/Frame 056585/0832 →