Proteins and immunizing compositions containing
Provided herein are isolated proteins isolatable from a Klebsiella spp. Also provided are compositions that include one or more of the proteins, and methods for making and methods for using the proteins.
1. A composition comprising:
an isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:41 and an isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:43;
an effective amount of an adjuvant; and
a pharmaceutically acceptable carrier.
2. The composition of claim 1 further comprising a protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:45, SEQ ID NO:46, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:58, SEQ ID NO:61, or SEQ ID NO:64.
3. A method comprising:
administering to a mammalian subject an amount of the composition of claim 1 effective to induce the subject to produce an antibody that specifically binds to at least one protein of the composition.
4. The method of claim 3 , wherein the mammalian subject is a bovine subject or a human subject.
5. The method of claim 3 , wherein the bovine subject is a dairy cow.