Concurrent MRSI and fMRI
A method of obtaining multiple MRI contrasts of a subject comprising the steps of concurrently acquiring an MRSI and fMRI data in the same scan.
1. A method of concurrently providing Magnetic Resonance Spectroscopic Imaging (MRSI) of water and metabolite signals and functional Magnetic Resonance Imaging (fMRI) of a brain, the method comprising:
performing, using a Magnetic Resonance Imaging (MRI) scanner, an MRSI data acquisition with a water suppression module, wherein a water readout module is inserted into the water suppression module, whereby MRSI data and fMRI data are acquired concurrently in a single scan;
reconstructing a water MRSI image of the brain based on the water readout module;
reconstructing an fMRI image of the brain based on the water readout module;
outputting the water MRSI image; and
outputting the fMRI image.
2. A system for concurrently providing Magnetic Resonance Spectroscopic Imaging (MRSI) of water and metabolite signals and functional Magnetic Resonance Imaging (fMRI) of a brain, the system comprising an MRI scanner and an electronic processor communicatively coupled to the Magnetic Resonance Imaging (MRI) scanner and configured to perform operations comprising:
performing, using the MRI scanner, an MRSI data acquisition with a water suppression module, wherein a water readout module is inserted into the water suppression module, whereby MRSI data and fMRI data are acquired concurrently in a single scan;
reconstructing a water MRSI image of the brain based on the water readout module;
reconstructing an fMRI image of the brain based on the water readout module;
outputting the water MRSI image; and
outputting the fMRI image.
3. The method of claim 1 , wherein the water readout module comprises multiple repetitions of the water suppression module.
4. The method of claim 1 , further comprising quantifying metabolite concentrations based on the metabolite signals and the water MRSI image.
5. The method of claim 1 , further comprising using the fMRI image to measure at least one of: task-based activation or resting-state connectivity.
6. The method of claim 1 , wherein the water suppression module uses a spectral-spatial RF pulse for water excitation to excite a slab.
7. The method of claim 6 , wherein the fMRI image comprises data encoded in a single shot within the slab.
8. The method of claim 1 , further comprising acquiring navigators during the water suppression module to perform at least one of: correction of movement related phase errors in MRSI and fMRI data, or correction of frequency drifts in MRSI and fMRI data.
9. The method of claim 1 , further comprising performing image registration to perform image motion correction across multiple repetitions of the water readout module.
10. The method of claim 1 , further comprising using the water readout to perform eddy current correction.
11. The method of claim 1 , further comprising using diffusion gradients as part of the water readout module.
12. The system of claim 2 , wherein the water readout module comprises multiple repetitions of the water suppression module.
13. The system of claim 2 , wherein the operations further comprise quantifying metabolite concentrations based on the metabolite signals and the water MRSI image.
14. The system of claim 2 , wherein the operations further comprise using the fMRI image to measure at least one of: task-based activation or resting-state connectivity.
15. The system of claim 2 , wherein the water suppression module uses a spectral-spatial RF pulse for water excitation to excite a slab.
16. The system of claim 15 , wherein the fMRI image comprises data encoded in a single shot within the slab.
17. The system of claim 2 , wherein the operations further comprise acquiring navigators during the water suppression module to perform at least one of: correction of movement related phase errors in MRSI and fMRI data, or perform correction of frequency drifts in MRSI and fMRI data.
18. The system of claim 2 , wherein the operations further comprise performing image registration to perform image motion correction across multiple repetitions of the water readout module.
19. The system of claim 2 , wherein the operations further comprise using the water readout to perform eddy current correction.
20. The system of claim 2 , wherein the operations further comprise using diffusion gradients as part of the water readout module.