Polylysine polymers with antimicrobial and/or anticancer activity
Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
1. A method, comprising:
inhibiting a cancer by contacting a cell of the cancer with a polymer, wherein the polymer comprises a polylysine structure functionalized with a pendent guanidinium functional group.
2. The method of claim 1 , wherein the inhibiting is facilitated by the polymer via a translocation mechanism that comprises translocating the polymer through a membrane of the cell and precipitating a biomacromolecule within a cytosol of the cell.
3. The method of claim 1 , wherein the polymer is further comprised within a coacervate complex that further comprises an anionic polymer, wherein the anionic polymer comprises another polylysine structure functionalized with a pendent anionic functional group, and wherein the pendent anionic functional group is selected from a group consisting of: a sulfonate group, a carboxylate group, a boronate group, and a phosphate group.
4. The method of claim 1 , wherein the polymer is comprised within a combination therapy with an anti-cancer agent, wherein the polymer enhances an anti-cancer activity of the anti-cancer agent.
5. The method of claim 1 , wherein in the cell is selected from a group consisting of a BT-474 cell and a HepG2 cell.
6. The method of claim 1 , wherein the polymer is characterized by a chemical formula:
wherein “m” is a first number greater than or equal to 5 and less than or equal to 30; and
wherein “n” is a second number greater than or equal to 0 and less than or equal to 25.