IP Library › Granted Patent US 11,872,291
Granted Patent B2
US 11,872,291 · App. 17/245,872 · Granted Jan 16, 2024

Fibroblast activation protein (FAP)-targeted imaging and therapy

Inventors: Philip Stewart Low (West Lafayette, IN); Jyoti Roy (West Lafayette, IN)
Assignee: PURDUE RESEARCH FOUNDATION
A61K51/0497A61K47/55A61K49/0032A61K49/0043A61K49/0052G01N33/56966
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Quick Facts
Patent No.
US 11,872,291
App. No.
17/245,872
Granted
Jan 16, 2024
Kind
B2
Abstract

The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for imaging cancer-associated fibroblasts (CAFs) in the tumor microenvironment of a patient. The present teachings relate generally to method of making conjugates comprising a fibroblast activation protein (FAP) inhibitor.

Claims (3)

1. A conjugate of the formula

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a conjugate of claim 1 , or a pharmaceutically acceptable salt thereof, and optionally at least one pharmaceutically acceptable excipient.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 4, 2023
From: LOW, PHILIP STEWART; ROY, JYOTI
To: PURDUE RESEARCH FOUNDATION
Reel/Frame 065753/0874 →
Continuity (4)
Continuation 16469907
Provisional Application 62434380 · Dec 14, 2016
Provisional Application 62575050 · Oct 20, 2017
Related Publication 20210316018A1 · Oct 14, 2021
Cited By (1)
US 12,397,069