Small molecule anticancer agents, combinations and uses thereof

1. A compound of Formula III, or salt thereof:

wherein, X is S or Se;

Y is S or Se;

R 3 is selected from H or C 1 -C 6 alkoxy;

R 4 is selected from H or C 1 -C 6 alkoxy;

n is 0, 1, 2, or 3;

o is 0, 1, 2, or 3; and

denotes a carbon-carbon single bond or double bond;

wherein if is a single bond, X and Y are both S, and n and o are each 1, then at least one of R 3 or R 4 is C 1 -C 6 alkoxy.

2. A compound, wherein the compound is:

1,2-diselenane-1,1-dioxide;

3,6-dihydro-1,2-dithiine-1,1-dioxide;

trans-1,2-dithiane-4,5-diol-1,1-dioxide;

trans-1,2-dithiane-4,5-diamino-1,1-dioxide;

trans-1,2-dithiane-4,5-diazido-1,1-dioxide;

cis-1,2-dithiane-4,5-diol-1,1-dioxide;

cis-1,2-dithiane-4,5-diamino-1,1-dioxide;

cis-1,2-dithiane-4,5-diazido-1,1-dioxide;

1,2-dithiane-4,5-dione-1,1-dioxide;

1,2-dithiane-(4R,5S-diacetoxy)-1,1-dioxide;

1,2-dithiane-(4S,5R-diacetoxy)-1,1-dioxide;

1,2-dithiane-(4R,5R-diacetoxy)-1,1-dioxide;

1,2-dithiane-(4S,5S-diacetoxy)-1,1-dioxide;

1,2-dithiane-(4R,5S-dihydroxy)-1,1-dioxide;

1,2-dithiane-(4S,5R-dihydroxy)-1,1-dioxide;

1,2-dithiane-(4R,5R-dihydroxy)-1,1-dioxide;

1,2-dithiane-(4S,5S-dihydroxy)-1,1-dioxide;

1,2-dithiane-4-amino-1,1-dioxide;

1,2-dithiane-4-azido-1,1-dioxide;

1,2-dithiane-5-amino-1,1-dioxide;

1,2-dithiane-5-azido-1,1-dioxide;

or a salt thereof.

3. The compound of claim 1 , or salt thereof, according to Formula (IV):

or salt thereof.

4. The compound of claim 1 , or a salt thereof, according to Formula (V):

Or salt thereof.

5. The compound of claim 1 , or a salt thereof, according to Formula (VI):

or salt thereof.

6. The compound of claim 1 , or a salt thereof, according to Formula (VII):

Or salt thereof.

7. The compound of claim 1 , or a salt thereof, according to Formula (VIII):

or salt thereof.

8. The compound of claim 1 , or a salt thereof, according to Formula (XIII):

Or salt thereof.

9. The compound of claim 1 , or a salt thereof, according to Formula (XVI):

Or salt thereof.

10. A pharmaceutical composition comprising a compound of claim 1 , or salt thereof, and a pharmaceutically acceptable carrier.

11. The composition of claim 10 , further comprising an additional therapeutic agent.

12. The composition of claim 11 , wherein the additional therapeutic agent is an additional anti-cancer agent.

13. A compound that is

or salt thereof.

14. The compound of claim 13 , that is

or a salt thereof.