IP Library Granted Patent US 11,850,346
Granted Patent B2
US 11,850,346 · App. 17/256,824 · Granted Dec 26, 2023

Beads for blood processing

Inventors: Yusuke Tokimizu (Tokyo, JP); Satoru Inoue (Tokyo, JP); Yoshihiro Hatanaka (Tokyo, JP)
Assignee: ASAHI KASEI MEDICAL CO., LTD.
A61M1/3679B01J20/261B01J20/262B01J20/28004B01J20/28016B01J20/28071B01J20/28073B01J20/28076B01J2220/445
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Quick Facts
Patent No.
US 11,850,346
App. No.
17/256,824
Granted
Dec 26, 2023
Kind
B2
Abstract

Provided are beads for blood processing having porous beads and a polymer carried on the surface of the porous beads, wherein: the porous beads are configured from at least one resin selected from the group consisting of acrylic resins, styrene resins, and cellulose resins; and the polymer includes a specific monomer defined in the description as a monomer unit.

Claims (20)

1. Beads for blood processing comprising porous beads and a polymer supported on the surfaces of the porous beads, wherein:

the porous beads are composed of at least one resin selected from the group consisting of acrylic-based resins, styrene-based resins and cellulose-based resins, and

the polymer includes, as a monomer unit, a monomer represented by following formula (1):

where R 1 is —CH 3 , R 2 is —CH 2 (CH 2 ) q OCH 3 or —CH 2 C m H 2m+1 , q is 1 to 5 and m is 0 to 17.

2. The beads for blood processing according to claim 1 , wherein a proportion of nitrogen atoms on the surfaces of the beads for blood processing is 0.2% to 0.7%, as the percentage of atoms based on the total number of atoms with atomic numbers of 3 to 92.

3. The beads for blood processing according to claim 2 , wherein the monomer represented by formula (1) is at least one selected from the group consisting of 2-methoxyethyl methacrylate, n-butyl methacrylate and lauryl methacrylate.

4. The beads for blood processing according to claim 1 , wherein q is 1 or 2 and m is 0 to 11.

5. The beads for blood processing according to claim 4 , wherein the content of the monomer represented by formula (1) is 40 mol % or greater with respect to the total monomers composing the polymer.

6. The beads for blood processing according to claim 5 , wherein the polymer further includes an additional monomer with at least one group selected from the group consisting of amino, carboxyl, phosphate, sulfonate and zwitterionic groups.

7. The beads for blood processing according to claim 6 , wherein the content of the additional monomer is 15 mol % to 40 mol % with respect to the total monomers composing the polymer.

8. The beads for blood processing according to claim 1 , wherein the polymer further includes a charged monomer as a monomer unit.

9. The beads for blood processing according to claim 1 , wherein the polymer further includes an additional monomer with at least one group selected from the group consisting of amino, carboxyl, phosphate, sulfonate and zwitterionic groups.

10. The beads for blood processing according to claim 9 , wherein the additional monomer is at least one selected from the group consisting of 2-aminoethyl methacrylate (AEMA), dimethylaminoethyl methacrylate (DMAEMA), diethylaminoethyl methacrylate (DEAEMA), [2-(methacryloyloxy)ethyl]trimethylammonium, acrylic acid (AAc), methacrylic acid (MAc), N-methacryloyloxyethyl-N,N-dimethylammonium-α-N-methylcarboxybetaine (CMB) and 2-(methacryloyloxy)ethyl 2-(trimethylammonio)ethyl phosphate (MPC).

11. The beads for blood processing according to claim 1 , wherein a proportion of the sum of carbon atoms and oxygen atoms on the surfaces of the beads for blood processing is 97.0% or higher, as the percentage of atoms based on the total number of atoms with atomic numbers of 3 to 92.

12. The beads for blood processing according to claim 1 , wherein the amount of the polymer is 0.08 mg to 114 mg per 1 g of dry weight of the porous beads.

13. The beads for blood processing according to claim 1 , wherein the amount of the polymer is 2.0 mg to 20 mg per 1 g of dry weight of the porous beads.

14. The beads for blood processing according to claim 1 , wherein the porous beads have a volume-average particle size of 300 μm to 1000 μm.

15. The beads for blood processing according to claim 1 , wherein the porous beads have a cumulative pore capacity for pore sizes of 5 nm to 100 nm of 0.5 cm 3 /g or higher and a cumulative pore capacity for pore sizes of 100 nm to 200 nm of 0.2 cm 3 /g or lower.

16. A blood purification device comprising the beads for blood processing according to claim 1 .

17. The beads for blood processing according to claim 1 , wherein the monomer represented by formula (1) is at least one selected from the group consisting of 2-methoxyethyl methacrylate, n-butyl methacrylate and lauryl methacrylate.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 29, 2020
From: TOKIMIZU, YUSUKE; INOUE, SATORU; HATANAKA, YOSHIHIRO
To: ASAHI KASEI MEDICAL CO., LTD.
Reel/Frame 054767/0583 →
Priority Claims (3)
JP 2018-126227 · Jul 2, 2018 · national
JP 2019-112280 · Jun 17, 2019 · national
JP 2019-112290 · Jun 17, 2019 · national
Continuity (1)
Related Publication 20210170362A1 · Jun 10, 2021