IP Library › Granted Patent US 12,357,947
Granted Patent B2
US 12,357,947 · App. 17/260,285 · Granted Jul 15, 2025

Systems and methods for tangential flow filtration of viscous compositions

Inventors: Ian Millet (Richmond, CA); Sailesh Haresh Daswani (Richmond, CA)
Assignee: ARC Medical Inc.
B01D61/18B01D61/145B01D61/22B01D2311/25B01D2313/04B01D2313/50B01D2315/10B01D2315/16B01D2317/04
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,357,947
App. No.
17/260,285
Granted
Jul 15, 2025
Kind
B2
Abstract

Apparatus, methods, systems, etc., for the tangential flow filtration (TFF) of viscous compositions including viscous fluids, solutions, gels, pastes, creams and suspensions with viscosities greater than 10 cP, 20 cP, 50 cP or 100 cP. The methods, etc., provide enhanced mixing of the viscous compositions in their storage vessels by extracting the input composition from different depths in the storage vessels to reduce or eliminate vertical concentration gradients.

Claims (34)

1. A tangential flow filtration system comprising:

a tangential flow filtration module;

a storage vessel comprising an input composition;

a tangential flow filtration input supply tube configured to deliver input composition from multiple depths within the storage vessel to the tangential flow filtration module, wherein the tangential flow filtration input supply tube comprises a plurality of inlet ports disposed at different heights within the storage vessel; and

a retentate return tube configured to return TFF retentate from the tangential flow filtration module to the storage vessel.

2. The tangential flow filtration system of claim 1 further comprising a recirculation system separate from the tangential flow filtration module and comprising a recirculation tube having a recirculation tube inlet disposed within the storage vessel at a depth selected to extract contents of the storage vessel and having a recirculation tube outlet disposed inside the storage vessel, wherein the recirculation system is configured such that anything in the recirculation system does not pass through the tangential flow filtration module and wherein the recirculation tube inlet and the recirculation tube outlet are located within in the storage vessel such that passage of the contents of the storage vessel through the recirculation system inhibits concentration gradients within the storage vessel.

3. A tangential flow filtration (TFF) system comprising:

a tangential flow filtration (TFF) module;

a storage vessel comprising an input composition;

a tangential flow filtration input supply tube operably connected to deliver input composition from the storage vessel to the tangential flow filtration module; and

a retentate return tube operably connected to return TFF retentate from the tangential flow filtration module to the storage vessel;

wherein the TFF system further comprises:

a recirculation system separate from the tangential flow filtration module and comprising a recirculation tube having a recirculation tube inlet comprising at least one additional inlet hole disposed along the length of a recirculation supply tube disposed within the storage vessel at a depth selected to extract contents of the storage vessel and having a recirculation tube outlet disposed inside the storage vessel, wherein the recirculation system is configured such that anything in the recirculation system does not pass through the tangential flow filtration module and wherein the recirculation tube inlet and the recirculation tube outlet are located within in the storage vessel such that passage of the contents of the storage vessel through the recirculation system inhibits concentration gradients within the storage vessel.

4. The tangential flow filtration system of any one of claim 2 or 3 wherein the recirculation system further comprises a recirculation system pump disposed to pump the contents of the storage vessel through the recirculation system, the recirculation system pump not connected to the tangential flow filtration module.

5. The tangential flow filtration system of any of claim 2 or 3 wherein the tangential flow filtration supply tube and the retentate return tube terminate at different depths in the interior of the storage vessel.

6. The tangential flow filtration system of any one of claim 2 or 3 wherein the retentate return tube terminates in the interior of the storage vessel above the storage vessel fill height.

7. The tangential flow filtration system of any one of claim 2 or 3 wherein the retentate return tube terminates in the interior of the storage vessel below the storage vessel fill height.

8. The tangential flow filtration system of any one of claim 2 or 3 wherein the retentate return tube terminates in the interior of the storage vessel proximate a bottom of the storage vessel.

9. The tangential flow filtration system of any one of claim 2 or 3 wherein the retentate return tube is directed towards a side in the interior of the storage vessel.

10. The tangential flow filtration system of any one of claim 2 or 3 wherein the recirculation tube outlet terminates in the interior of the storage vessel above a storage vessel fill height.

11. The tangential flow filtration system of any one of claim 2 or 3 wherein the recirculation tube outlet terminates in the interior of the storage vessel below a storage vessel fill height.

12. The tangential flow filtration system of any one of claim 2 or 3 wherein the recirculation tube outlet terminates in the interior of the storage vessel proximate a bottom of the storage vessel.

13. The tangential flow filtration system of any one of claim 2 or 3 wherein the recirculation tube outlet is directed towards a side in the interior of the storage vessel.

14. The tangential flow filtration system of any of claim 2 or 3 further comprising a diafiltration solution supply tube configured to deliver diafiltration solution to the retentate return tube upstream from the storage vessel.

15. The tangential flow filtration system of any of claim 2 or 3 wherein the tangential flow filtration system and tangential flow filtration module are configured to retain and filter a viscous composition without a substantial concentration gradient in the viscous composition.

16. The tangential flow filtration system of any of claim 2 or 3 further comprising a storage vessel cap, wherein the tangential flow filtration input supply tube and the retentate return tube extend through the storage vessel cap into the interior of the storage vessel.

17. The tangential flow filtration system of claim 16 wherein the storage vessel cap seals aseptically to the top of the storage vessel.

18. A tangential flow filtration (TFF) system comprising:

a tangential flow filtration (TFF) module;

a storage vessel comprising an input composition;

a tangential flow filtration input supply tube operably connected to deliver input composition from the storage vessel to the tangential flow filtration module; and

a retentate return tube operably connected to return TFF retentate from the tangential flow filtration module to the storage vessel;

wherein the TFF system further comprises:

a recirculation system separate from the tangential flow filtration module and comprising a recirculation tube having a recirculation tube inlet disposed within the storage vessel at a depth selected to extract contents of the storage vessel and having a recirculation tube outlet disposed inside the storage vessel, wherein the recirculation system is configured such that anything in the recirculation system does not pass through the tangential flow filtration module and wherein the recirculation tube inlet and the recirculation tube outlet are located within in the storage vessel such that passage of the contents of the storage vessel through the recirculation system inhibits concentration gradients within the storage vessel, and wherein the recirculation tube outlet terminates in the interior of the storage vessel below a storage vessel fill height.

Assignments (2)
CHANGE OF NAME Recorded Oct 15, 2024
From: ARC MEDICAL DEVICES INC.
To: ARC MEDICAL INC.
Reel/Frame 069163/0020 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2024
From: DASWANI, SAILESH HARESH; MILLET, IAN
To: ARC MEDICAL DEVICES INC.
Reel/Frame 068897/0095 →
Continuity (2)
Provisional Application 62814212 · Mar 5, 2019
Related Publication 20220226779A1 · Jul 21, 2022
References Cited (140)
US 5616595A · Chu et al. · 1997 [cited by applicant]
US 5772900A · Yorita et al. · 1998 [cited by applicant]
US 5958244A · Hartmann · 1999 [cited by examiner]
US 6868715B1 · Carnahan et al. · 2005 [cited by applicant]
US 8426381B2 · Thibodeau et al. · 2013 [cited by applicant]
US 8466125B2 · Springate · 2013 [cited by applicant]
US 9833741B2 · Roh · 2017 [cited by examiner]
US 10139378B2 · Kang · 2018 [cited by applicant]
US 20030085166A1 · Dreyer · 2003 [cited by examiner]
US 20030224346A1 · Karlsson · 2003 [cited by applicant]
US 20040014179A1 · Thwaites · 2004 [cited by applicant]
US 20070122875A1 · Sakai · 2007 [cited by applicant]
US 20070298508A1 · Deslauriers et al. · 2007 [cited by applicant]
US 20080063682A1 · Cashman et al. · 2008 [cited by applicant]
US 20090105910A1 · Hatano et al. · 2009 [cited by applicant]
US 20090170801A1 · Hao · 2009 [cited by applicant]
US 20090170810A1 · Hao · 2009 [cited by applicant]
US 20110021457A1 · Springate · 2011 [cited by applicant]
US 20110172156A1 · Dockal et al. · 2011 [cited by applicant]
US 20150041395A1 · Oranth · 2015 [cited by examiner]
US 20170328873A1 · Kang · 2017 [cited by applicant]
US 20180051097A1 · Springate et al. · 2018 [cited by applicant]
CA 2769147 · 2011 [cited by applicant]
CN 1437650 · 2003 [cited by applicant]
CN 1985846 · 2007 [cited by applicant]
CN 101011411 · 2007 [cited by applicant]
CN 101037483 · 2007 [cited by applicant]
CN 101156664 · 2008 [cited by applicant]
CN 101659709 · 2010 [cited by applicant]
CN 102665733 · 2012 [cited by applicant]
CN 102911281 · 2013 [cited by applicant]
CN 202778304 · 2013 [cited by applicant]
CN 104586878 · 2015 [cited by applicant]
CN 105399848 · 2016 [cited by applicant]
CN 106176798 · 2016 [cited by applicant]
CN 106832022 · 2017 [cited by applicant]
CN 107155305 · 2017 [cited by applicant]
CN 10738266 · 2017 [cited by applicant]
CN 207333195U · 2018 [cited by examiner]
CN 112513165 · 2019 [cited by applicant]
EA 201270186 · 2012 [cited by applicant]
EA 25808 · 2017 [cited by applicant]
EP 100843 · 1984 [cited by applicant]
EP 0567914 · 1993 [cited by applicant]
EP 1277834 · 2003 [cited by applicant]
JP 10182703 · 1998 [cited by applicant]
JP 2005507077 · 2005 [cited by applicant]
JP 2005508893 · 2005 [cited by applicant]
JP 2005517955 · 2005 [cited by applicant]
JP 2007504273 · 2007 [cited by applicant]
JP 2010519383 · 2010 [cited by applicant]
JP 2013500274 · 2013 [cited by applicant]
JP 2013517285 · 2013 [cited by applicant]
JP 2013180994 · 2013 [cited by applicant]
JP 2014124579 · 2014 [cited by applicant]
JP 2016505083 · 2016 [cited by applicant]
JP 2016128491 · 2016 [cited by applicant]
JP 2017206542 · 2017 [cited by applicant]
JP 2018513383 · 2018 [cited by applicant]
KR 20060031936 · 2006 [cited by applicant]
KR 20060051439 · 2006 [cited by applicant]
KR 20100138440 · 2010 [cited by applicant]
KR 20160011952 · 2016 [cited by applicant]
KR 101950246 · 2019 [cited by applicant]
PH 12012500177 · 2012 [cited by applicant]
RU 2247574 · 2005 [cited by applicant]
RU 2497525 · 2013 [cited by applicant]
RU 2591161 · 2016 [cited by applicant]
RU 2015135635 · 2017 [cited by applicant]
RU 2638859 · 2018 [cited by applicant]
WO WO2008031332 · 2008 [cited by applicant]
WO WO2008041799 · 2008 [cited by applicant]
WO WO2008103234 · 2008 [cited by applicant]
WO WO2010110223 · 2010 [cited by applicant]
WO WO2011011881 · 2011 [cited by applicant]
WO WO2014113836 · 2014 [cited by applicant]
WO WO2016117599 · 2016 [cited by applicant]
WO WO2017042603 · 2017 [cited by applicant]
WO WO2017160739 · 2017 [cited by applicant]
WO WO2020176989 · 2020 [cited by applicant]
WO WO2020176990 · 2020 [cited by applicant]
Abstracts of the 25th Annual Meeting of ESHRE, Amsterdam, The Netherlands, Jun. 28, 2009-Jul. 1, 2009. [cited by applicant]
Ale et al., “Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds,” Mar. Drugs, Oct… [cited by applicant]
Baba et al., “Effects of extraction solvent on fucose content in fucoidan extracted from brown seaweed ( [cited by applicant]
Balboa et al., “Valorization of Sargassum muticum Biomass According to the Biorefinery Concept,” Marine Drugs, Jun. 11, 2015, vol. 13, pp. 3745-3760. [cited by applicant]
Cashman, Johanne et al., “Fucoidan Film Safely Inhibit Surgical Adhesions in a Rat Model,” Journal of Surgical Research, vol. 171, pp. 495-603, 2011. [cited by applicant]
Chen et al., “A new extraction method for fucoidan from the soaked water of brown seaweed ( [cited by applicant]
Chizhov et al., “A study of fucoidan from the brown seaweed Chorda filum,” Carbohydrate Research, Jul. 20, 1999, vol. 320, pp. 108-119. [cited by applicant]
Corrigan, N. et al., “Copolymers with Controlled Molecular Weight Distributions and Compositional Gradients through Flow Polymerization,” Macromolecules, 2018, vol. 51(12), pp. 4553-4563. [cited by applicant]
Croci, D.O. et al., “Fucans, but not Fucomannoglucornonas, Determine the Biological Activities of Sulfated Polysaccharides from [cited by applicant]
Cumashi, Albana et al., “A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds,” Glycobiology, vol. 17, No. 5, pp. 541-5… [cited by applicant]
Deniaud-Bouet, E. et al., “Chemical and enzymatic fractionation of cell walls from Fucals: insights into the structure of the extracellular matrix of brown algae,” Annals of Botany, May 29, 2014, vol. 114, pp. 1203-1216. [cited by applicant]
Fernando et al., “A fucoidan fraction purified from Chnoospoora minima: a potential inhibitor of LPS-induced inflammatory responses,” International Journal of Biological Marcromolecules, 2017, vol. 104, pp. 1185-1193. [cited by applicant]
Dorschmann, Phillip et al., “Effects of Sulfated Fucans from Laminaria hyperborean Regarding VEGF Secretion, Cell Viability, and Oxidative Stress and Correlation with Molecular Weight,” Marine Drugs, 2019, vol. 17, No. … [cited by applicant]
Fitton, Janet et al., “Therapies from Fucoidan: An Update” Marine Drugs, vol. 13, No. 9, Sep. 6, 2016, pp. 5920-5946. [cited by applicant]
Fujikawa, Tatsuo et al., “Occurrence of Fucoidan and Fucoidan Analogues in Brown Seaweed,” Agricultural Chemistry, vol. 49, No. 9, 1975, pp. 455-461. [cited by applicant]
Greco et al., “A Simple and Effective Method for High Quality Co-Extraction of Geonomic DNA and Total RNA from Low Biomass [cited by applicant]
“Guidance for Industry, Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers,” U.S. Department of Health and Human Services Food and Drug Administration Cente… [cited by applicant]
Hahn et al., “Novel Procedures for the extraction of fucoidan from brown algae,” Process Biochemistry, Jun. 23, 2012, vol. 47, pp. 1691-1698. [cited by applicant]
Haroun-Bouhedja et al., “Relationship between Sulfate Groups and Biological,” Thrombosis Research, Dec. 1, 2000, vol. 100(5), pp. 453-459. [cited by applicant]
Hoagland, “The Complex Carbohydrates and Forms of Sulphur in Marine Algae of the Pacific Coast,” The Journal of Biological Chemistry, 1915, vol. 23(1), pp. 287-297. [cited by applicant]
International Search Report and Written Opinion relating to International Patent Application No. PCT/CA2019/051026, mailed Oct. 16, 2019, 17 pages. [cited by applicant]
International Search Report and Written Opinion relating to International Patent Application No. PCT/CA2019/051027, mailed Nov. 20, 2019, 15 pages. [cited by applicant]
International Search Report and Written Opinion relating to International Patent Application No. PCT/CA2019/051030, mailed Nov. 27, 2019, 24 pages. [cited by applicant]
International Search Report and Written Opinion relating to International Patent Application No. PCT/CA2019/051028, mailed Nov. 15, 2019, 27 pages. [cited by applicant]
International Search Report and Written Opinion relating to International Patent Application No. PCT/CA2019/051029, mailed Dec. 12, 2019, 15 pages. [cited by applicant]
International Search Report and Written Opinion relating to International Patent Application No. PCT/CA2020/050294, mailed May 29, 2020, 8 pages. [cited by applicant]
International Search Report and Written Opinion relating to International Patent Application No. PCT/CA2020/050295, mailed Jun. 5, 2020, 12 pages. [cited by applicant]
Kim, et al., “Molecular weight and sulfate content modulate the inhibition of a-amylase by fucoidan relevant for type 2 diabetes management,” PharmaNutrition, Jul. 2015, vol. 3(3), pp. 108-114. [cited by applicant]
Kopplin, Georg et al., “Structural Characterization of Fucoidan from Laminaria hyperborean: Assessment of Coagulation and Inflammatory Properties and Their Structure-Fucan Relationship,” Applied Bio Materials, 2018, vol… [cited by applicant]
Koyanagi et al., “Oversulfation of Fucoidan Enhances its Anti-Angiogenic and Anti-Tumor Activities,” Biochemical Pharmacology, Jan. 15, 2003, vol. 65(2), pp. 173-179. [cited by applicant]
Lee et al., “Variation in Fucoidan Contents and Monosaccharide Compositions of Korean Undaria pinnatifida (Harvey) Surigar (Phaephyta),” Algae, vol. 21:1, 2006, 157-160. [cited by applicant]
Li et al., “Fucoidan: Structure and Bioactivity,” Molecules, Aug. 12, 2008, vol. 13, pp. 1671-1695. [cited by applicant]
Ly et al., “Studies on Fucoidan and its Production from Vietnamese Brown Seaweeds,” ASEAN Journal on Science and Technology for Development, 2005, vol. 22(4), pp. 371-380. [cited by applicant]
Mabeau, Serge et al., “Fractionation and Analysis of Fucans from Brown Algae”, Phytochemistry, vol. 29, No. 8, pp. 2441-2445, 1990. [cited by applicant]
Makarenkova, I D et al., “Sulfated polysaccharides of brown seaweeds are ligands of toll-like receptors,” Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, SP Maik Nauka, Interperiodica, Dordrecht, vol. 6… [cited by applicant]
Men'Shova, R.V. et al., “Effect of pretreatment conditions of brown algae by supercritical fluids on yield and structural characteristics of fucoidans,” Chemistry of Natural Compounds, Jan. 2013, vol. 48, No. 6, pp. 923… [cited by applicant]
Mulloy, Barbara et al., “Sulfated fucans from Echinoderms have a regular tetrasaccharide repeating unit defined by specific patterns of sulfation at the 0-2 and 0-4 positions Analysis View project,” Oct. 1, 1994, DOI: 1… [cited by applicant]
Nishino, Takashi et al., “Anticoagulant and antithrombin activities of oversulfated fucans,” Carbohydrate Research, 229 (1992) 355-362. [cited by applicant]
Pereira, M.S. et al., “Is there a correlation between structure and anticoagulant action of sulfated galactans and sulfated fucans,” Glycobiology, Oct. 1, 2002, vol. 12(10), pp. 573-580, downloaded from the internet htt… [cited by applicant]
Qiu et al., “Effect of oversulfation on the chemical and biological properties of fucoidan,” Carbohydrate Polymers, Nov. 21, 2005, vol. 63, pp. 224-228. [cited by applicant]
Regis et al., “Regioselective desulfation of sulfated L-fucopyranoside by a new sulfoesterase from the marine mollusk [cited by applicant]
Saboural, P. et al. “Purification of a Low Molecular Weight Fucan for SPECT Molecular Imaging of Myocardial Infarction,”, Marine Drugs 2014, vol. 12, pp. 4851-4867. [cited by applicant]
Sakai, Takeshi et al., Polymers, Jul. 2006, vol. 55, pp. 488-489. [cited by applicant]
Seimon, T.A. et al., “Combinational pattern recognition receptor signaling alters the balance of life and death in macrophages,” PNAS Cell Biology (2006), vol. 103, No. 52, pp. 19794-19799. [cited by applicant]
Sezer, A.D. et al., “Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits,” Biol Pharm Bull. 2008, vol. 31(12), pp. 2326-2333. [cited by applicant]
Simurant et al., “Purification and Characterization of Fucoidan From the Brown Seaweed [cited by applicant]
Soeda et al., “Preparation of oversulfated fucoidan fragments and evaluations of their antithrombotic activities,” Thrombosis Research, Nov. 1, 1993, vol. 72(3), pp. 247-256. [cited by applicant]
Soeda et al., “Oversulfated fucoidan and heparin suppress endotoxin induction of plasminogen activator inhibitor-1 in cultured human endothelial cells: their possible mechanism of action,” Biochimica et Biophysica Acta … [cited by applicant]
Usui et al., “Isolation of Highly Purified Fucoidan from Eisenia bicyclis and Its Anticoagulant and Antitumor Activities,” Agric. Biol. Chem, Mar. 12, 1980, vol. 44(8), pp. 1965-1966. [cited by applicant]
Wang, “Impacts of Processing and Storage Methods on the Yield and Composition of Fucoidan from Undaria pinnatifida,” Auckland University of Technology, Nov. 2014, pp. 1-71. [cited by applicant]
Wijesinghe et al., “Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: A review,” Carbohydrate Polymers, Dec. 24, 2011, vol. 8… [cited by applicant]
Wu et al., “Liquid-Liquid Extraction of Fucoidan Leached from Brown Seaweeds,” The Chinese Journal of Process Engineering, Feb. 2002, ISSN http://en.cnki.com.cn/Article_en/CJFDTota1-HGYJ200202006.htm. [cited by applicant]
Wu, “Solvent Extraction of Fucoidan in Aqueous Solution with Quaternary Ammonium Salt as Extractant,” Chinese High Technology Letters, Aug. 2001, ISSN http://en.cnki.com.cn/Article_en/CJFDTotal-GJSX200108009.htm. [cited by applicant]
Wu et al., “Structural Analysis and Anticoagulant Activities of the Novel Sulfated Fucan Possessing a Regular Well-Defined Repeating Unit from Sea Cucumber,” Marine Drugs, Apr. 13, 2015, vol. 13, p. 2063-2084. [cited by applicant]
Xing et al., “Extraction and Separation of Fucoidan from Laminaria japonica with Chitosan as Extractant,” Hindawi Publishing Corporation, 2013, pp. 1-4. [cited by applicant]
Zayed et al., “Physiochemical and Biological Characterization of Fucoidan from Fucus vesiculosus Purified by Dye Affinity Chromatography,” Marine Drugs, Apr. 15, 2016, vol. 14(4), pp. 1-15. [cited by applicant]
Zhang, H. et al., “Control of molecular weight distribution for polypropylene obtained by commercial Ziegler-Natta catalyst: effect of temperature,” Polym. Bull. 2011, vol. 67, pp. 1519-1527. [cited by applicant]
Zhao, Yu et al., “Fucoidan Extracted from Undaria pinnatifida: Source for Nutraceuticals/Functional Foods,” Marine Drugs, 2018, vol. 16: 321, 17 pages. [cited by applicant]
Zhao et al., “The Removal of Lead from Purified Fucoidan Extracted from Kelp Laminari japonica,” Fisheries Science, Feb. 2012, ISSN http://en.cnki.com.cn/Artic1e_en/CJFDTOTAL-CHAN201202011.htm. [cited by applicant]