Granted Patent B2

US 12,187,747 · App. 17/268,845 · Granted Jan 7, 2025

Inventors: Mingdi Yan (Lowell, MA); Bin Wu (Lowell, MA); William G. Ndugire (Lowell, MA); Olof Ramstrom (Lowell, MA)

Assignee: UNIVERSITY OF MASSACHUSETTS

C07F1/005A61P31/04

Abstract

Claims (17)

1. A compound or salt of Formula VIII or a pharmaceutically acceptable salt thereof wherein

Au a (X) x (Y) y (W) w (Z) z    (Formula VIII)

X is an aromatic or aliphatic phosphine of the following formulas

Y is a sugar;

W is —S 2 C 2 (CN) 2 , —SC 2 H 5 , or —SC 2 H 4 Ph;

Z is NO 3 or halogen;

a is at least 10;

w is 0 to 14;

x is 1 to 14;

y is 0 to 14; and

z is 0 to 6.

2. The compound or salt of claim 1 , wherein X is

3. The compound or salt claim 1 , wherein X is

and Y is

4. The compound or salt of claim 1 , wherein the size of the compound is no more than 50 nanometers.

5. The compound or salt of claim 1 , wherein the size of the compound is from 0.5 to 50 nanometers.

6. A pharmaceutical composition comprising a compound or salt of claim 1 together with a pharmaceutically acceptable carrier.

Assignments (1)

Continuity (2)

References Cited (17)