IP Library Granted Patent US 12,357,994
Granted Patent B2
US 12,357,994 · App. 17/270,848 · Granted Jul 15, 2025

PCR reaction container

Inventors: Hidenori Nagai (Ikeda, JP); Shunsuke Furutani (Ikeda, JP); Hideyasu Kubo (Tokyo, JP)
Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY; KYORIN PHARMACEUTICAL CO., LTD.
B01L7/52B01L3/502753B01L2200/0689B01L2300/0681B01L2300/0832
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Quick Facts
Patent No.
US 12,357,994
App. No.
17/270,848
Granted
Jul 15, 2025
Kind
B2
Abstract

A PCR vessel having: a substrate, a flow channel formed in the substrate, a pair of filters provided at both ends of the flow channel, a pair of air communication ports communicating with the flow channel through the filters, a thermal cycle region formed between the pair of filters in the flow channel, and a sample injection port through which a sample can be injected into the flow channel from above; wherein the sample injection port in the surface of the substrate has an area of 0.7 to 1.8 mm 2 .

Claims (20)

1. A PCR vessel comprising:

a substrate comprising a surface,

a flow channel formed in the substrate,

a pair of filters provided at both ends of the flow channel,

a pair of air communication ports communicating with the flow channel through the filters,

a thermal cycle region that is in the flow channel between the pair of filters where heat is applied, and

a sample injection port formed to connect the surface of the substrate and the flow channel through which a sample can be injected into the flow channel between one of the filters and the thermal cycle region, without mediating a branch flow channel, wherein the sample injection port in the surface of the substrate has an area of 0.7 mm 2 to 1.8 mm 2 .

2. The PCR vessel according to claim 1 , wherein the sample injection port is circular, elliptical, or polygonal.

3. The PCR vessel according to claim 1 , wherein the flow channel has a width of 300 μm to 1000 μm.

4. The PCR vessel according to claim 1 , wherein a sample can be injected into the flow channel using a sample injection member that is separate from the PCR vessel and that has a circular or polygonal tubular shape in which an end of the sample injection member reaches the inside of the flow channel.

5. The PCR vessel according to claim 1 , wherein the sample injection port has a volume of 7.5 μL or less, which is a space between the surface of the substrate and the flow channel.

6. The PCR vessel according to claim 1 , wherein after sample injection, an upper opening of the sample injection port can be sealed with a sample injection member that is separate from the PCR vessel.

7. The PCR vessel according to claim 1 , which has a thickness of 3 mm to 5 mm.

8. The PCR vessel according to claim 2 , wherein the flow channel has a width of 300 μm to 1000 μm.

9. The PCR vessel according to claim 8 , wherein a sample can be injected into the flow channel using a sample injection member that is separate from the PCR vessel and that has a circular or polygonal tubular shape in which an end of the sample injection member reaches the inside of the flow channel.

10. The PCR vessel according to claim 9 , wherein the sample injection port has a volume of 7.5 μL or less, which is a space between the surface of the substrate and the flow channel.

11. The PCR vessel according to claim 10 , wherein the substrate has a thickness of 3 mm to 5 mm.

12. The PCR vessel according to claim 1 , wherein the PCR vessel further comprises a seal attached to the substrate, and wherein an upper opening of the sample injection port can be sealed with the seal after sample injection.

13. The PCR vessel according to claim 10 , wherein the PCR vessel further comprises a seal attached to the substrate, and wherein an upper opening of the sample injection port can be sealed with the seal after sample injection.

14. The PCR vessel according to claim 13 , wherein the substrate has a thickness of 3 mm to 5 mm.

Assignments (4)
ASSIGNEE ADDRESS CHANGE Recorded Oct 2, 2024
From: KYORIN PHARMACEUTICAL CO., LTD.
To: KYORIN PHARMACEUTICAL CO., LTD.
Reel/Frame 069109/0377 →
MERGER Recorded Oct 2, 2024
From: KYORIN PHARMACEUTICAL CO., LTD.
To: KYORIN HOLDINGS, INC.
Reel/Frame 068775/0688 →
CHANGE OF NAME Recorded Oct 2, 2024
From: KYORIN HOLDINGS, INC.
To: KYORIN PHARMACEUTICAL CO., LTD.
Reel/Frame 068775/0697 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 23, 2021
From: NAGAI, HIDENORI; FURUTANI, SHUNSUKE; KUBO, HIDEYASU
To: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY; KYORIN PHARMACEUTICAL CO., LTD.
Reel/Frame 055378/0671 →
Priority Claims (1)
JP 2018-161316 · Aug 30, 2018 · national
Continuity (1)
Related Publication 20210187510A1 · Jun 24, 2021
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