IP Library Granted Patent US 12,280,088
Granted Patent B2
US 12,280,088 · App. 17/274,666 · Granted Apr 22, 2025

Dry powder formulation of caveolin-1 peptides and methods of use thereof

Inventors: Robert O. Williams, III (Austin, TX); Alan B. Watts (Austin, TX); Yajie Zhang (Austin, TX); Sawittree Sahakijpijarn (Austin, TX); Dale Christensen (Austin, TX); John J. Koleng (Austin, TX)
Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; Rein Therapeutics, Inc.
A61K38/08A61K9/00A61K9/0075A61K9/14A61K38/10A61K45/06A61P11/00C07K7/06C07K7/08C07K2319/10
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Quick Facts
Patent No.
US 12,280,088
App. No.
17/274,666
Granted
Apr 22, 2025
Kind
B2
Abstract

Provided herein are compositions comprising caveolin-1 (Cav-1) peptides. Further provided are methods of using the Cav-1 peptides for the treatment of lung infections or acute or chronic lung injury, particularly lung fibrosis.

Claims (22)

1. A dry powder composition comprising particles,

wherein the particles comprise a peptide consisting of FTTFTVT (SEQ ID NO: 2) or a pharmaceutically acceptable salt thereof,

wherein the particles have a median particle diameter of less than 5 μm,

wherein the dry powder composition does not comprise a pharmaceutically acceptable carrier or excipient; and

wherein the dry powder composition is formulated for use in a dry powder inhaler.

2. The dry powder composition of claim 1 , wherein the dry powder composition is encapsulated.

3. The dry powder composition of claim 1 , wherein the dry powder composition is encased in a shell capsule.

4. The dry powder composition of claim 1 , wherein the pharmaceutically acceptable salt is an ammonium salt.

5. The dry powder composition of claim 1 , wherein the pharmaceutically acceptable salt is an acetate salt.

6. The dry powder composition of claim 1 , wherein the particles are amorphous.

7. The dry powder composition of claim 1 , wherein the particles have a median particle diameter between about 1 μm to about 5 μm.

8. The dry powder composition of claim 1 , wherein the particles have a median particle diameter of about 2 μm, about 2.5 μm, or about 3 μm.

9. The dry powder composition of claim 1 , wherein the dry powder composition is stable for at least 1 month, at least 3 months, or at least 6 months.

10. The dry powder composition of claim 1 , wherein the dry powder composition is stable for at least 6 months.

11. The dry powder composition of claim 1 , wherein the dry powder is produced by a milling process.

12. The dry powder composition of claim 11 , wherein the dry powder is produced by air jet milling.

13. The dry powder composition of claim 11 , wherein the dry powder is produced by ball milling, wet milling, or cryogenic milling.

14. The dry powder composition of claim 1 , wherein the dry powder is produced by a spray-drying process.

15. A dry powder inhaler comprising the dry powder composition of claim 1 .

16. The dry powder composition of claim 1 , wherein at least 70% of the particles have a particle size of about 1 μm to about 5 μm.

17. The dry powder composition of claim 1 , wherein 75%-95% of the particles have a particle size less than 5 μm.

18. The dry powder composition of claim 1 , wherein the median particle diameter of the particles is a mass median aerodynamic diameter (MMAD).

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 3, 2025
From: LUNG THERAPEUTICS, LLC
To: REIN THERAPEUTICS, INC.
Reel/Frame 070380/0626 →
MERGER AND CHANGE OF NAME Recorded Apr 9, 2024
From: LUNG THERAPEUTICS, INC.; AT MERGER SUB II, LLC
To: LUNG THERAPEUTICS, LLC
Reel/Frame 067043/0478 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 27, 2021
From: WILLIAMS, ROBERT O., III; WATTS, ALAN B.; ZHANG, YAJIE; SAHAKIJPIJARN, SAWITTREE
To: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 057929/0056 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 27, 2021
From: CHRISTENSEN, DALE; KOLENG, JOHN J.
To: LUNG THERAPEUTICS, INC.
Reel/Frame 057929/0128 →
Continuity (2)
Provisional Application 62729010 · Sep 10, 2018
Related Publication 20210260150A1 · Aug 26, 2021
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