Intravertebral direct current block of spinal transmission of neural signals
The present disclose relates to intravertebral electrical block of spinal transmission of neural signals (at least a portion of sensory signals from the peripheral nervous system and/or at least a portion of motor signals to the peripheral nervous system). At least one intravertebral electrode can be located at a level of a spinal cord of a subject. At least one waveform generator can be coupled to the at least one intravertebral electrode and configured to generate an electrical signal that is sent to the at least one intravertebral electrode for application to the level of the spinal cord of the subject.
1. A method comprising:
receiving, by at least one intravertebral electrode surgically implanted into dura at a level of a spinal cord of a subject and by at least one other intravertebral electrode surgically implanted into the dura at another level of the spinal cord of the subject, an electrical signal configured to block spinal transmission of at least a portion of peripherally induced sensory signals, wherein the electrical signal comprises a direct current waveform, and wherein the at least one intravertebral electrode and the at least one other intravertebral electrode each comprise a high-capacitance electrode material; and
delivering, by the at least one intravertebral electrode and the at least one other intravertebral electrode, the electrical signal to the level of the spinal cord and the other level of the spinal cord, respectively, wherein delivery of the electrical signal to the level of the spinal cord and the other level of the spinal cord blocks spinal transmission of at least the portion of the peripherally induced sensory signals in one or more spinal tracts at the level of the spinal cord and the other level of the spinal cord.
2. The method of claim 1 , wherein the high-capacitance electrode material comprises carbon.
3. The method of claim 2 , wherein the high-capacitance electrode material comprises is a carbon coated platinum electrode, a woven cloth carbon electrode, or a carbon slurry electrode.
4. The method of claim 1 , wherein the at least one intravertebral electrode and/or the at least one other intravertebral electrode is a separated interface nerve electrode (SINE).
5. The method of claim 1 , wherein the level of the spinal cord is at least one of and the other level of the spinal cord is at least one other of a sacral level of the spine, a thoracic level of the spine, and/or a lumbar level of the spine.
6. The method of claim 1 , further comprising inserting the at least one intravertebral electrode and/or the at least one other intravertebral electrode through a sacral foramen, wherein the level of the spinal cord comprises at least a sacral level of the spine.
7. The method of claim 1 , further comprising inserting the at least one intravertebral electrode and/or the at least one other intravertebral electrode through a surgical fenestration in a lumbar lamina, wherein the level of the spinal cord comprises at least a lumbar level of the spine.
8. The method of claim 1 , further comprising generating, by a waveform generator device coupled to the at least one intravertebral electrode and the at least one other intravertebral electrode, the electrical signal configured to block spinal transmission of at least the portion of peripherally induced sensory signals.
9. The method of claim 8 , further comprising receiving, by the waveform generator, an input corresponding to a value of at least one of the one or more parameters.
10. A system comprising:
at least one intravertebral electrode configured to be surgically implanted into dura at a level of a spinal cord of a subject, wherein the at least one intravertebral electrode comprises a high-capacitance electrode material;
at least one other intravertebral electrode configured to be surgically implanted into dura at another level of the spinal cord of the subject, wherein the at least one other intravertebral electrode comprises the high-capacitance electrode material; and
at least one waveform generator, coupled to the at least one intravertebral electrode and the at least one other intravertebral electrode, configured to generate an electrical signal comprising a direct current waveform that is sent to the at least one intravertebral electrode and the at least one other intravertebral electrode for application to the level of the spinal cord of the subject and the other level of the spinal cord of the subject, wherein the electrical signal comprising the direct current waveform is configured to block spinal transmission of at least a portion of peripherally induced sensory signals in one or more spinal tracts at the level of the spinal cord and the other level of the spinal cord.
11. The system of claim 10 , wherein the high-capacitance electrode material comprises a separated interface nerve electrode (SINE), a carbon coated platinum electrode, a woven cloth carbon electrode, or a carbon slurry electrode.
12. The system of claim 10 , wherein the level of the spinal cord is at least on of and the other level of the spinal cord is at least one other of a sacral level of the spine, a thoracic level of the spine, and/or a lumbar level of the spine.
13. The system of claim 10 , wherein the at least one intravertebral electrode and/or the at least one other intravertebral electrode is configured to be inserted through a sacral foramen in the subject's body, wherein the level of the spinal cord comprises at least a sacral level of the spine.
14. The system of claim 10 , further comprising a controller, coupled to the waveform generator, configured to set one or more parameters of the electrical signal.
15. The system of claim 14 , wherein the controller is configured to set the one or more parameters of the electrical signal based on a feedback signal from a sensor within the subject's body.
16. The system of claim 14 , wherein the controller is configured to set the one or more parameters of the electrical signal based on a user input.
17. The method of claim 1 , wherein the electrical signal at least partially blocks spinal transmission of the at least the portion of the peripherally induced sensory signals.
18. The system of claim 10 , wherein the at least one intravertebral electrode and the at least one other intravertebral electrode are configured to apply the electrical signal comprising the direct current waveform to block spinal transmission of the at least the portion of the peripherally induced sensory signals without causing a Faradaic reaction.