IP Library › Granted Patent US 12,502,435
Granted Patent B2
US 12,502,435 · App. 17/282,257 · Granted Dec 23, 2025

Metastatic brain tumor targeting peptides

Inventors: James K. Liu (Lutz, FL); Daniel Abate-Daga (Tampa, FL); Cecilia Ramello (Tampa, FL)
Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
A61K47/64A61K35/17A61K39/0011A61K39/3955A61K47/65C07K14/7051A61K2039/5156C07K2319/02C07K2319/03
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Quick Facts
Patent No.
US 12,502,435
App. No.
17/282,257
Granted
Dec 23, 2025
Kind
B2
Abstract

Compositions and methods are disclosed for targeted treatment of lung cancer-derived metastatic brain tumors. In particular, tumor targeting agents comprising targeting peptides are disclosed that can target a payload, such as a therapeutic or diagnostic agent, to lung cancer-derived metastatic brain tumors. Chimeric antigen receptor (CAR) polypeptides are disclosed that can be used with adoptive cell transfer to target and kill lung cancer-derived metastatic brain tumors.

Claims (5)

1 . A molecule comprising a peptide conjugated to an anti-cancer agent, wherein the peptide comprises the amino acid sequence SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:4, or a variant having at least 10, 11, 12, 13, 14, or 15 contiguous amino acids and at least 90%-sequence identity to SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:4.

2 . The molecule of claim 1 , wherein the peptide is separated from the anti-cancer agent by a linker.

3 . The molecule of claim 2 , wherein the linker comprises the amino acid sequence GGGS (SEQ ID NO:79), GGGSGG (SEQ ID NO:80), GGGSGGGS (SEQ ID NO:81), GGGGSGGGGSGGGGS (SEQ ID NO:82), GGGGSGGGGSGGGGSGG (SEQ ID NO:83), or GGGGSGGGGSGGGGSGGGGS (SEQ ID NO:84).

4 . A pharmaceutical composition comprising the molecule of claim 1 in a pharmaceutically acceptable carrier.

5 . A method for treating a lung cancer-derived metastatic brain tumor in a subject, comprising administering to the subject a therapeutically effective amount of the pharmaceutical composition of claim 4 .

Assignments (2)
CONFIRMATORY LICENSE Recorded Nov 22, 2023
From: H. LEE MOFFITT CANCER CTR & RES INST
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065666/0564 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2021
From: LIU, JAMES K.; ABATE-DAGA, DANIEL; RAMELLO, CECILIA
To: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Reel/Frame 056531/0371 →
Continuity (3)
Provisional Application 62755434 · Nov 3, 2018
Provisional Application 62746850 · Oct 17, 2018
Related Publication 20230018705A1 · Jan 19, 2023
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