Astrocyte-specific nucleic acid aptamer and use thereof
The present specification relates to an astrocyte-specific nucleic acid aptamer and a use thereof. The astrocyte-specific nucleic acid aptamer, according to the disclosure in the present specification, is a DNA aptamer.
1. An aptamer capable of binding an astrocyte,
wherein the aptamer is a single strand,
wherein the aptamer consists of 80 or less nucleotides, and
wherein the aptamer comprises a polynucleotide sequence of any one of SEQ ID NOs: 1 to 10, or a fully complementary polynucleotide sequence thereof.
2. The aptamer of claim 1 ,
wherein the aptamer further comprises a primer sequence in a first terminal or a second terminal of the polynucleotide sequence of any one of the SEQ ID NOs: 1 to 10; or
in a first terminal or a second terminal of the fully complementary polynucleotide sequence to any one of the SEQ ID NOs: 1 to 10.
3. The aptamer of the claim 1 ,
wherein the aptamer conjugates with an imaging agent selected from an inorganic sulfide, an oxide, a halide, a contrast medium and a fluorescent protein.