Probiotic supplement for metabolic health
The application discloses Lactobacillus strains having a beneficial effect on the metabolic health on a mammalian subject. Further disclosed is compositions comprising such strains and the use thereof for improving the metabolic health or for lowering the blood glucose level in a mammalian subject.
1. A Lactobacillus strain selected from DSM 32910, DSM 32911, DSM 32851 and DSM 32853, wherein the strain is in freeze-dried from or spray-dried form.
2. The Lactobacillus strain according to claim 1 , wherein the strain has the ability of improving or alleviating one or more prediabetes symptoms selected from insulin resistance, high-blood glucose, low-grade inflammation and gut barrier function.
3. The Lactobacillus strain according to claim 1 , wherein the strain survives in the gastrointestinal (GI) tract.
4. The Lactobacillus strain according to claim 1 , wherein the strain is DSM 32851.
5. A composition comprising a Lactobacillus strain according to claim 1 .
6. The composition according to claim 5 , wherein the composition comprises 10 6 -10 14 colony forming units (CFU) of total Lactobacillus strain per gram of the composition.
7. A dietary supplement comprising a Lactobacillus strain according to claim 1 .
8. A method of improving the metabolic health of an individual, the method comprising administering to the individual in need of improving the metabolic health a Lactobacillus strain according to claim 1 .
9. The method of claim 8 , wherein improving the metabolic health is selected from alleviating prediabetes, preventing or alleviating type 2 diabetes, alleviating insulin resistance, improving liver health, reducing gut inflammation, improving gut barrier function, lowering blood glucose level, and preventing or reducing weight gain from a high fat diet.
10. The method of claim 8 wherein the individual is a human.
11. The composition according to claim 5 , wherein the composition comprises 10 7 -10 13 colony forming units (CFU) of total Lactobacillus strain per gram of the composition.
12. The composition according to claim 5 , wherein the composition comprises 10 8 -10 12 colony forming units (CFU) of total Lactobacillus strain per gram of the composition.
13. The composition according to claim 5 , wherein the composition comprises the Lactobacillus strain deposited as DSM 32851 and one or more Lactobacillus strains selected from the strains deposited as DSM 17648, DSM 32910, DSM 32911 and DSM 32853.
14. The composition according to claim 5 , wherein the composition comprises the Lactobacillus strain deposited as DSM 32910 and one or more Lactobacillus strains selected from the strains deposited as DSM 17648, DSM 32911, DSM 32851 and DSM 32853.
15. The Lactobacillus strain according to claim 1 , wherein the strain is in freeze-dried form.
16. The Lactobacillus strain according to claim 1 , wherein the strain is in spray-dried form.
17. The Lactobacillus strain according to claim 1 , wherein the strain is DSM 32910.
18. The Lactobacillus strain according to claim 1 , wherein the strain is DSM 32911.
19. The Lactobacillus strain according to claim 1 , wherein the strain is DSM 32853.