IP Library › Granted Patent US 12,590,099

Granted Patent B2

US 12,590,099 · App. 17/288,626 · Granted Mar 31, 2026

Inhibitors of histone deacetylase useful for the treatment or prevention of HIV infection

Inventors: Wensheng Yu (Edison, NJ); Joseph Kozlowski (Princeton, NJ); Dane James Clausen (Rahway, NJ); Jian Liu (Edison, NJ); Younong Yu (East Brunswick, NJ); Ming Wang (Belle Mead, NJ); Bing Li (Towaco, NJ)

Assignee: Merck Sharp & Dohme LLC

C07D487/10 A61K45/06 C07D401/12 C07D401/14 C07D403/12 C07D405/14 C07D413/14 C07D417/14 C07D471/04 C07D498/10

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Quick Facts

Patent No.: US 12,590,099
App. No.: 17/288,626
Granted: Mar 31, 2026
Kind: B2

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USPTO Patent Center↗ Full Patent PDF↗

Abstract

The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof, wherein R 1 , R 2 , R 3 , R 4 and A are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing HIV infection in a subject.

Claims (1050)

1 . A compound being one of:

(S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

oxononyl)-6-oxaspiro[2.5]octane-1-carboxamide

(R)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

oxononyl)-6-oxaspiro[2.5]octane-1-carboxamide

(1S)-N-[(1S)-1-{5-[2-(dimethylamino)quinolin-6-yl]-1H-imidazol-

2-yl}-7-oxononyl]-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(1,5-naphthyridin-3-yl)-1H-imidazol-2-yl)-7-oxo-

nonyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-9,9,9-trifluoro-1-(5-(4-fluorophenyl)-1H-

imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-ethylquinolin-6-yl)-1H-imidazol-2-yl)-7-oxo-

nonyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(1S)-N-{(1S)-1-[5-(7-fluoro-2-methylquinolin-6-yl)-1H-imidazol-

2-yl]-7-oxononyl}-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-1-(5-(1-methyl-2-oxo-1,2-dihydroquinolin-6-

yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carbo-

xamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-((1R,4S)-1,2,3,4-tetrahydro-1,4-

methanonaphthalen-6-yl)-1H-imidazol-2-yl)nonyl)-6-azaspiro

[2.5]octane-1-carboxamide

(S)-N-((S)-1-(4-fluoro-5-(2-methoxyquinolin-3-yl)-1H-imidazol-

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(4-cyano-2-(4-fluorophenyl)-1H-imidazol-5-yl)-7-

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)-7-oxo-

nonyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)-7-oxo-

nonyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(1S)-6-methyl-N-[(1S)-7-oxo-1-{5-[2-(trifluoromethyl)quino-

lin-6-yl]-1,3-oxazol-2-yl}nonyl]-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(4-(pyridin-3-yl)phenyl)oxazol-2-

yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-1-(5-(2-methylquinolin-6-yl)oxazol-2-yl)-7-

oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(1S)-N-{(1S)-1-[4-chloro-5-(2-hydroxyquinolin-3-yl)-1H-

imidazol-2-yl]-7-oxononyl}-6-methyl-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(quinoxalin-6-yl)-1H-imidazol-2-

yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-isopropyl-N-((S)-1-(5-(2-methylquinolin-6-yl)-1H-imidazol-

2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-8-cyclopropyl-1-(5-(4-fluorophenyl)-1H-imidazol-2-

yl)-7-oxooctyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(4-oxo-4H-chromen-3-yl)-1H-

imidazol-2-yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(benzo[d]oxazol-6-yl)-1H-imidazol-2-yl)-7-

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(6-cyanonaphthalen-2-yl)-1H-imidazol-2-yl)-7-

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(4-chloro-2-(4-fluorophenyl)-1H-imidazol-5-yl)-7-

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(2-ethyl-1-oxo-1,2-dihydroisoquinolin-6-

yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-ethyl-N-((S)-7-oxo-1-(5-(4-(thiazol-2-yl)phenyl)oxazol-2-

yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(4-(oxazol-2-yl)phenyl)oxazol-2-yl)-7-

oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(4-(1H-pyrazol-1-yl)phenyl)oxazol-2-yl)-7-

oxononyl)-6-ethyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-isopropyl-N-((S)-1-(5-(1-methyl-2-oxo-1,2-dihydroquinolin-

6-yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carbo-

xamide

(S)-6-ethyl-N-((S)-1-(5-(1-methyl-2-oxo-1,2-dihydroquinolin-6-

yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(1,8-naphthyridin-3-yl)-1H-imidazol-2-yl)-7-

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-isopropyl-N-((S)-1-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)-

7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-cyclopropylquinolin-6-yl)-1H-imidazol-2-yl)-7-

100

oxononyl)-6-isopropyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(1-methyl-2-oxo-1,2-dihydroquinolin-6-

101

yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxypyridin-3-yl)-1H-imidazol-2-yl)-7-

102

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(cinnolin-6-yl)-1H-imidazol-2-yl)-7-oxononyl)-6-

103

methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(2-cyclopropylquinolin-6-

104

yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carbo-

xamide

(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-oxo-

105

nonyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carbo-

xamide

N-{(1S)-1-[5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl]-7-

106

oxononyl}-8-(1-methylethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-

3-carboxamide

(S)-N-((S)-1-(5-(7-methoxyquinolin-6-yl)-1H-imidazol-2-yl)-7-

107

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(1S)-N-{(1S)-1-[5-(2-cyclopropyl-7-methoxyquinolin-6-yl)-1H-

108

imidazol-2-yl]-7-oxononyl}-6-methyl-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-methyl-N-((S)-1-(5-(1-methyl-2-oxo-1,2-dihydroquinolin-6-

109

yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(1S)-N-{(1S)-1-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]-7-oxononyl}-

110

6-ethyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-cyclopropyl-7-fluoroquinolin-6-yl)oxazol-2-yl)-

111

7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-cyclopropylquinolin-6-yl)-1H-imidazol-2-yl)-7-

112

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(3-methoxyisoquinolin-6-yl)-1H-imidazol-2-yl)-7-

113

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-cyclopropylquinolin-6-yl)oxazol-2-yl)-7-

114

oxononyl)-6-ethyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(2-cyclopropylquinolin-6-

115

yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-cyclopropylquinolin-6-yl)oxazol-2-yl)-7-

116

oxononyl)-6-isopropyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-1-(5-(2-(oxazol-2-yl)quinolin-6-yl)-1H-

119

imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(1S)-N-[(1S)-1-{5-[4-(2-azetidin-1-ylpyrimidin-5-yl)phenyl]-1,3-

120

oxazol-2-yl}-7-oxononyl]-6-ethyl-6-azaspiro[2.5]octane-1-

carboxamide

(S)-N-((S)-1-(5-(2-cyclopropylquinolin-6-yl)oxazol-2-yl)-7-

121

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(1R,4s)-N-((S)-1-(5-(2-cyclopropylquinolin-6-yl)oxazol-2-yl)-7-

122

oxononyl)-7′-oxo-7′H-spiro[cyclohexane-1,5′-furo[3,4-b]pyridine]-

4-carboxamide

(1R,4s)-N-((S)-1-(5-(2-cyclopropylquinolin-6-yl)oxazol-2-yl)-7-

123

oxononyl)-7′-oxo-7′H-spiro[cyclohexane-1,5′-furo[3,4-b]pyridine]-

4-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)-7-

124

oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)-7-

125

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(2-isopropyl-1-oxo-1,2-dihydroiso-

126

quinolin-6-yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro

[2.5]octane-1-carboxamide

6-(dimethylamino)-N-{(1S)-1-[5-(2-methoxyquinolin-3-yl)-1H-

127

imidazol-2-yl]-7-oxononyl}spiro[2.5]octane-1-carboxamide

(1S)-N-[(1S)-1-{5-[4-(5-cyclopropylpyrazin-2-yl)phenyl]-1,3-

129

oxazol-2-yl}-7-oxononyl]-6-ethyl-6-azaspiro[2.5]octane-1-

carboxamide

5,5,6-trimethyl-N-{(1S)-1-[5-(2-methylquinolin-6-yl)-1H-

130

imidazol-2-yl]-7-oxononyl}-6-azaspiro[2.5]octane-1-carboxamide

(1S)-N-{(1S)-1-[4-(4-fluorophenyl)-1H-imidazol-2-yl]-8-hydroxy-

134

7-oxononyl}-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-(1-(5-(2-cyclopropylquinolin-6-yl)oxazol-2-yl)-7-oxononyl)-

135

8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carboxamide

(S)-N-(1-(5-(2-cyclopropylquinolin-6-yl)oxazol-2-yl)-7-oxononyl)-

136

8-isopropyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carboxamide

(S)-6-methyl-N-((S)-1-(5-(2-methyl-1-oxo-1,2-dihydroisoquinolin-

137

6-yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carbo-

xamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(2-oxo-2H-chromen-6-yl)-1H-

138

imidazol-2-yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(6-cyclopropylpyridin-3-yl)-1H-imidazol-2-yl)-7-

139

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(3-chloroquinolin-6-yl)-1H-imidazol-2-yl)-7-

140

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(1R,4s)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-

141

7-oxononyl)-7′-oxo-7′H-spiro[cyclohexane-1,5′-furo[3,4-b]

pyridine]-4-carboxamide

(S)-N-((S)-1-(5-(2-methoxy-1,5-naphthyridin-3-yl)-1H-imidazol-

142

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(4-(6-cyclopropylpyridin-3-yl)phenyl)oxazol-2-

143

yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-1-(5-(1-methyl-2-oxo-1,2-dihydroquinolin-6-

144

yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-7-methyl-N-(1-(5-(2-methyl-2H-indazol-5-yl)-1H-imidazol-2-

145

yl)-7-oxononyl)-7-azaspiro[3.5]nonane-2-carboxamide

(S)-N-((S)-1-(5-(2-cyclopropylbenzo[d]thiazol-6-yl)-1H-imidazol-

146

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-2-methyl-N-(1-(5-(2-methyl-2H-indazol-5-yl)-1H-imidazol-2-

147

yl)-7-oxononyl)-2-azaspiro[3.3]heptane-6-carboxamide

(S)-N-((S)-1-(5-(2-methoxy-1,7-naphthyridin-3-yl)-1H-imidazol-

148

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-ethylbenzo[d]thiazol-6-yl)-1H-imidazol-2-yl)-

149

7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-cyclopropyl-1-oxo-1,2-dihydroisoquinolin-6-

150

yl)-1H-imidazol-2-yl)-7-oxononyl)-6-ethyl-6-azaspiro[2.5]octane-

1-carboxamide

(1S)-1-methyl-6-(1-methylethyl)-N-{(1S)-1-[5-(2-methylquinolin-

151

6-yl)-1H-imidazol-2-yl]-7-oxononyl}-6-azaspiro[2.5]octane-1-

carboxamide

(1S)-1-methyl-6-(1-methylethyl)-N-{(1S)-1-[5-(2-methylquinolin-

152

6-yl)-1H-imidazol-2-yl]-7-oxononyl}-6-azaspiro[2.5]octane-1-

carboxamide

(S)-N-((S)-1-(5-(2-cyclopropyl-1-oxo-1,2-dihydroisoquinolin-6-

153

yl)oxazol-2-yl)-7-oxononyl)-6-ethyl-6-azaspiro[2.5]octane-1-

carboxamide

(S)-8-methyl-N-(1-(5-(2-methyl-2H-indazol-5-yl)-1H-imidazol-

154

2-yl)-7-oxononyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carbo-

xamide

(S)-N-(1-(5-(2-methyl-2H-indazol-5-yl)-1H-imidazol-2-yl)-7-

155

oxononyl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide

(S)-2-methyl-N-(1-(5-(2-methyl-2H-indazol-5-yl)-1H-imidazol-

156

2-yl)-7-oxononyl)-2-azaspiro[3.5]nonane-7-carboxamide

(S)-6-isobutyl-2-methyl-N-(1-(5-(2-methylquinolin-6-yl)-1H-

157

imidazol-2-yl)-7-oxononyl)-2-azaspiro[3.3]heptane-6-carboxamide

(S)-N-((S)-1-(5-(2-(1H-pyrazol-1-yl)quinolin-6-yl)-1H-imidazol-

158

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(1-cyclopropyl-1H-indazol-5-yl)-1H-imidazol-2-

159

yl)-7-oxononyl)-6-ethyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-cyclopropylbenzo[d]oxazol-6-yl)-1H-imidazol-

160

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(4-(2-cyclopropylpyrimidin-5-yl)phenyl)oxazol-2-

161

yl)-7-oxononyl)-6-ethyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(2-ethyl-1-oxo-1,2-dihydroisoquinolin-6-

162

yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(1S)-N-{(1S)-1-[5-(7-methoxy-2-methylquinolin-6-yl)-1,3-oxazol-

163

2-yl]-7-oxononyl}-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(7-methoxyquinolin-6-yl)oxazol-2-yl)-7-oxo-

164

nonyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-8-cyclopropyl-1-(5-(7-methoxy-2-methylquinolin-6-yl)-

165

1H-imidazol-2-yl)-7-oxooctyl)-6-ethyl-6-azaspiro[2.5]octane-1-

carboxamide

8-methyl-N-[(1S)-7-oxo-1-(5-quinolin-6-yl-1H-imidazol-2-yl)

166

nonyl]-8-azaspiro[bicyclo[3.2.1]octane-3,1′-cyclopropane]-2′-

carboxamide

(S)-N-((S)-8-cyclopropyl-1-(5-(7-methoxy-2-methylquinolin-6-

167

yl)oxazol-2-yl)-7-oxooctyl)-6-ethyl-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-ethyl-N-((S)-1-(5-(2-methoxy-1,7-naphthyridin-3-yl)oxazol-

168

2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(7-methoxyquinolin-6-yl)oxazol-2-yl)-7-

169

oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(4-methoxyquinolin-2-yl)-1H-imidazol-2-yl)-7-

170

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(7-methoxy-1-methyl-2-oxo-1,2-dihydro-

171

quinolin-6-yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-N-((S)-1-(5-(7-methoxy-2-methylquinolin-6-yl)-1H-imidazol-

172

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(2-ethyl-7-methoxy-1-oxo-1,2-dihydro-

173

isoquinolin-6-yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-

1-carboxamide

(S)-N-((S)-1-(5-(4-chloro-2-methylquinolin-6-yl)-1H-imidazol-2-

174

yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(1S)-N-[(1S)-1-{5-[2-methoxy-7-(1,3-oxazol-2-yl)quinolin-3-yl]-

175

1H-imidazol-2-yl}-7-oxononyl]-6-methyl-6-azaspiro[2.5]octane-1-

carboxamide

(1S)-N-[(1S)-1-{5-[2-methoxy-7-(1H-pyrazol-1-yl)quinolin-3-yl]-

176

1H-imidazol-2-yl}-7-oxononyl]-6-methyl-6-azaspiro[2.5]octane-

1-carboxamide

(S)-N-((S)-1-(5-(7-chloro-2-methoxyquinolin-3-yl)-1H-imidazol-

177

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(1S)-N-{(1S)-7-oxo-1-[5-(9-prop-2-en-1-yl-1,2,3,4-tetrahydro-1,4-

179

epiminonaphthalen-6-yl)-1H-imidazol-2-yl]nonyl}-6-prop-2-en-1-

yl-6-azaspiro[2.5]octane-1-carboxamide

(1S)-N-{(1S)-7-oxo-1-[5-(9-prop-2-en-1-yl-1,2,3,4-tetrahydro-1,4-

180

epiminonaphthalen-5-yl)-1H-imidazol-2-yl]nonyl}-6-prop-2-en-1-

yl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(7-methoxyquinolin-6-yl)-1H-imidazol-2-

181

yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-isopropyl-N-((S)-1-(5-(7-methoxy-2-methylquinolin-6-yl)-

182

1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-N-((S)-1-(5-(2,4-dimethoxyphenyl)-1H-imidazol-2-yl)-7-

183

oxononyl)-6-ethyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-8-cyclobutyl-1-(5-(7-methoxy-2-methylquinolin-6-

184

yl)oxazol-2-yl)-7-oxooctyl)-6-ethyl-6-azaspiro[2.5]octane-1-

carboxamide

(S)-N-((S)-8-cyclobutyl-1-(5-(7-methoxy-2-methylquinolin-6-yl)

185

oxazol-2-yl)-7-oxooctyl)-6-methyl-6-azaspiro[2.5]octane-1-

carboxamide

(1S)-6-cyclobutyl-N-{(1S)-1-[5-(7-methoxy-2-methylquinolin-6-

186

yl)-1H-imidazol-2-yl]-7-oxononyl}-6-azaspiro[2.5]octane-1-

carboxamide

(1S)-6-(cyclopropylmethyl)-N-{(1S)-1-[5-(7-methoxy-2-methyl-

187

quinolin-6-yl)-1H-imidazol-2-yl]-7-oxononyl}-6-azaspiro[2.5]

octane-1-carboxamide

(S)-N-(1-(5-(7-methoxy-2-methylquinolin-6-yl)-1H-imidazol-2-

188

yl)-7-oxononyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

(S)-6-ethyl-N-((S)-1-(5-(5-methoxy-2-methyl-2H-indazol-6-

189

yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(5-methoxy-2-methyl-2H-indazol-6-yl)-

190

1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carbo-

xamide

(S)-N-((S)-1-(5-(7-methoxy-2-methylquinolin-6-yl)-1,3,4-oxa-

191

diazol-2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-

carboxamide

(S)-8-(cyclopropylmethyl)-N-(1-(5-(7-methoxy-1-methyl-2-oxo-

192

1,2-dihydroquinolin-6-yl)-1H-imidazol-2-yl)-7-oxononyl)-1-oxa-

2,8-diazaspiro[4.5]dec-2-ene-3-carboxamide

(S)-N-(1-(5-(7-methoxy-1-methyl-2-oxo-1,2-dihydroquinolin-6-

193

yl)oxazol-2-yl)-7-oxononyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]

dec-2-ene-3-carboxamide

(1S)-N-{(1S)-8-cyclopropyl-1-[5-(7-methoxy-2-methylquinolin-6-

195

yl)-1,3-oxazol-2-yl]-7-oxooctyl}-6-methyl-6-azaspiro[2.5]octane-

1-carboxamide

(S)-N-(1-(5-(7-methoxy-2-methylquinolin-6-yl)oxazol-2-yl)-7-

196

oxononyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carbo-

xamide

(S)-6-ethyl-N-((S)-1-(5-(4-fluoro-2-methoxyphenyl)-1H-imidazol-

197

2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(7-methoxy-1-methyl-2-oxo-1,2-dihydroquinolin-

198

6-yl)oxazol-2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(7-methoxy-1-methyl-2-

199

oxo-1,2-dihydroquinolin-6-yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro

[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(7-chloro-2-methylquinolin-6-yl)-1H-imidazol-2-

200

yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-8-cyclopropyl-1-(5-(4-fluorophenyl)-1H-imidazol-2-

201

yl)-7-oxooctyl)-6-ethyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-8-cyclopropyl-1-(5-(2-methoxypyridin-3-yl)-1H-

202

imidazol-2-yl)-7-oxooctyl)-6-ethyl-6-azaspiro[2.5]octane-1-carbo-

xamide

(S)-8-ethyl-N-(1-(5-(7-methoxy-2-methylquinolin-6-yl)oxazol-2-

204

yl)-7-oxononyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carbo-

xamide

(S)-6-ethyl-N-((S)-1-(5-(7-methoxyquinoxalin-6-yl)-1H-imidazol-

205

2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(6-methoxy-2-methyl-2H-indazol-5-yl)-

206

1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carbo-

xamide

(S)-8-ethyl-N-(1-(5-(7-methoxy-2-methylquinolin-6-yl)-1H-

207

imidazol-2-yl)-7-oxononyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-

3-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(2-methoxy-4-methylphenyl)-1H-imida-

208

zol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(1S)-N-{(1S)-1-[5-(7-ethyl-2-methylquinolin-6-yl)-1H-imidazol-

210

2-yl]-7-oxononyl}-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(7-methoxy-2-methylquinolin-6-yl)-1H-

211

imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

{2-[(1S)-1-({[(1S)-6-ethyl-6-azaspiro[2.5]oct-1-yl]carbonyl}

215

amino)-7-oxononyl]-4-(7-methoxy-2-methylquinolin-6-yl)-1H-

imidazol-1-yl}methyl 2,2-dimethylpropanoate

(S)-N-(1-(5-(2-methoxy-1,7-naphthyridin-3-yl)oxazol-2-yl)-7-

216

oxononyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carbo-

xamide

(S)-N-((S)-1-(5-(2,7-dimethylquinolin-6-yl)-1H-imidazol-2-yl)-7-

218

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-8-(cyclopropylmethyl)-N-(1-(5-(7-methoxy-2-methylquinolin-

219

6-yl)-1H-imidazol-2-yl)-7-oxononyl)-1-oxa-2,8-diazaspiro[4.5]

dec-2-ene-3-carboxamide

(S)-N-((S)-1-(5-(5-fluoro-2-methoxypyridin-4-yl)oxazol-2-yl)-7-

220

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-(1-(5-(7-fluoro-2-methylquinolin-6-yl)oxazol-2-yl)-7-

221

oxononyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

N-{(1S)-1-[5-(2-methoxy-4-pyridin-3-ylphenyl)-1,3-oxazol-2-yl]-

222

7-oxononyl}-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

(S)-N-(1-(5-(7-methoxyquinolin-6-yl)oxazol-2-yl)-7-oxononyl)-8-

223

methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carboxamide

(S)-8-(cyclopropylmethyl)-N-(1-(5-(7-methoxy-2-methylquinolin-

225

6-yl)oxazol-2-yl)-7-oxononyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-

ene-3-carboxamide

(S)-N-((S)-1-(5-(7-fluoro-2-methylquinolin-6-yl)oxazol-2-yl)-7-

226

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(7-fluoro-2-methylquino-

228

lin-6-yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(7-methoxy-2-methyl-1-

229

oxo-1,2-dihydroisoquinolin-6-yl)oxazol-2-yl)-7-oxononyl)-6-

azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(7-methoxy-2-methylquinolin-6-yl)oxazol-2-yl)-7-

230

oxononyl)-5-methyl-5-azaspiro[2.3]hexane-1-carboxamide

(R)-N-((S)-1-(5-(7-methoxy-2-methylquinolin-6-yl)oxazol-2-yl)-7-

231

oxononyl)-5-methyl-5-azaspiro[2.3]hexane-1-carboxamide

(S)-N-(1-(5-(7-fluoro-2-methylquinolin-6-yl)-1H-imidazol-2-yl)-7-

232

oxononyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

(S)-8-ethyl-N-(1-(5-(7-fluoro-2-methylquinolin-6-yl)-1H-imidazol-

233

2-yl)-7-oxononyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

(S)-8-(cyclopropylmethyl)-N-(1-(5-(7-fluoro-2-methylquinolin-6-

234

yl)-1H-imidazol-2-yl)-7-oxononyl)-1-oxa-2,8-diazaspiro[4.5]dec-

2-ene-3-carboxamide

(S)-8-ethyl-N-(1-(5-(7-methoxy-1-methyl-2-oxo-1,2-dihydro-

235

quinolin-6-yl)oxazol-2-yl)-7-oxononyl)-1-oxa-2,8-diazaspiro

[4.5]dec-2-ene-3-carboxamide

(S)-8-(cyclopropylmethyl)-N-(1-(5-(7-methoxy-1-methyl-2-oxo-

236

1,2-dihydroquinolin-6-yl)oxazol-2-yl)-7-oxononyl)-1-oxa-2,8-

diazaspiro[4.5]dec-2-ene-3-carboxamide

N-{(1S)-1-[5-(2-methoxy-4-pyrazin-2-ylphenyl)-1,3-oxazol-2-yl]-

237

7-oxononyl}-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

(S)-N-((S)-1-(5-(2-cyclopropyl-2H-indazol-5-yl)-1H-imidazol-2-

238

yl)-7-oxononyl)-6-ethyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(4-fluorophenyl)-1H-imidazol-2-yl)-7-oxodecyl)-

239

6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(4-chloro-2-(4-fluorophenyl)-1H-imidazol-5-yl)-7-

240

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(2-(pyrrolidin-1-yl)quinolin-6-yl)-

241

1H-imidazol-2-yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(isoquinolin-6-yl)-1H-imidazol-2-yl)-7-

243

oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(7-methoxy-2-methylquinolin-6-yl)-1H-

243

imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(7-methoxy-1-methyl-2-oxo-1,2-dihydro-

244

quinolin-6-yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]

octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(2-ethyl-7-methoxy-1-oxo-1,2-dihydro-

245

isoquinolin-6-yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]

octane-1-carboxamide

6-ethyl-N-((S)-1-(2-(4-fluorophenyl)-5-(3-methoxyphenyl)-1H-

246

imidazol-4-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

6-ethyl-N-((S)-1-(2-(4-fluorophenyl)-5-(2-methoxypyrimidin-5-

247

yl)-1H-imidazol-4-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

6-ethyl-N-((S)-1-(2-(4-fluorophenyl)-5-(1-methyl-1H-pyrazol-4-

248

yl)-1H-imidazol-4-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

6-ethyl-N-((S)-1-(2-(4-fluorophenyl)-5-(1H-pyrazol-4-yl)-1H-

249

imidazol-4-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

6-ethyl-N-((S)-1-(2-(4-fluorophenyl)-5-(thiophen-3-yl)-1H-

250

imidazol-4-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

6-ethyl-N-((S)-1-(2-(4-fluorophenyl)-5-(1-methyl-1H-pyrrol-3-

251

yl)-1H-imidazol-4-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

6-ethyl-N-((S)-1-(2-(4-fluorophenyl)-5-(thiophen-2-yl)-1H-

252

imidazol-4-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

6-ethyl-N-((S)-1-(2-(4-fluorophenyl)-5-(1-methyl-1H-pyrazol-5-

253

yl)-1H-imidazol-4-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

6-ethyl-N-((S)-1-(2-(4-fluorophenyl)-5-(1-propyl-1H-pyrazol-4-

254

yl)-1H-imidazol-4-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-N-((S)-1-(5-(2-methoxypyrimidin-5-yl)-1H-imidazol-2-yl)-7-

255

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-1-(5-(3-methyl-3H-imidazo[4,5-b]pyridin-6-

256

yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-methyl-N-((S)-1-(5-(2-(4-methyl-1H-pyrazol-1-yl)pyrimidin-

257

5-yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(1S)-6-methyl-N-((1S)-7-oxo-1-(5-(4-((tetrahydrofuran-3-

258

yl)carbamoyl)phenyl)-1H-imidazol-2-yl)nonyl)-6-azaspiro[2.5]

octane-1-carboxamide

(S)-N-((S)-1-(5-(1,5-naphthyridin-3-yl)-1H-imidazol-2-yl)-7-

259

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(4-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl)-1H-

260

imidazol-2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-

carboxamide

(S)-N-((S)-1-(5-(3-fluoro-2-morpholinopyridin-4-yl)-1H-imidazol-

261

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-([2,3′-bipyridin]-5-yl)-1H-imidazol-2-yl)-7-

262

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(quinolin-3-yl)-1H-imidazol-2-

263

yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-1-(5-(1-methyl-1H-indol-3-yl)-1H-imidazol-

264

2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-1-(5-(9-methyl-9H-carbazol-3-yl)-1H-

265

imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-ethoxypyrimidin-5-yl)-1H-imidazol-2-yl)-7-

266

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-imidazol-

267

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxy-6-methylpyridin-3-yl)-1H-imidazol-

268

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-8-ethyl-N-(1-(5-(7-fluoro-2-methylquinolin-6-yl)oxazol-2-yl)-

269

7-oxononyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carboxamide

(S)-2-ethyl-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-

271

7-oxononyl)-2-azaspiro[3.5]nonane-7-carboxamide

(S)-N-(1-(5-(2-methoxy-4-(pyridin-2-yl)phenyl)oxazol-2-yl)-7-

272

oxononyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

(S)-2-(2-isopropyl-2-azaspiro[3.3]heptan-6-yl)-N-(1-(5-(2-

273

methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-oxononyl)acetamide

(S)-2-ethyl-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-

274

7-oxononyl)-2-azaspiro[3.5]nonane-7-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-

275

yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-amino-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-

276

7-oxononyl)-2-methyl-2-azaspiro[3.3]heptane-6-carboxamide

(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

277

oxononyl)-7-methyl-7-azaspiro[3.5]nonane-2-carboxamide

(S)-7-ethyl-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-

278

7-oxononyl)-7-azaspiro[3.5]nonane-2-carboxamide

(S)-2-ethyl-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-

279

7-oxononyl)-2-azaspiro[3.3]heptane-6-carboxamide

(S)-N-((S)-1-(5-(4-fluorophenyl)-1H-imidazol-2-yl)-7-oxononyl)-

280

6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(R)-6-methyl-N-((S)-7-oxo-1-(5-(quinolin-6-yl)-1H-imidazol-2-

281

yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(quinolin-6-yl)-1H-imidazol-2-

282

yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(quinolin-3-yl)-1H-imidazol-2-

283

yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(4-(trifluoromethyl)phenyl)-1H-

284

imidazol-2-yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(1R)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

285

oxononyl)-5-methyl-5-azaspiro[2.5]octane-1-carboxamide

(1S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

286

oxononyl)-5-methyl-5-azaspiro[2.5]octane-1-carboxamide

(1S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

287

oxononyl)-5-methyl-5-azaspiro[2.5]octane-1-carboxamide

(1R)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

288

oxononyl)-5-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2,4-difluorophenyl)-1H-imidazol-2-yl)-7-

289

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-fluorophenyl)-1H-imidazol-2-yl)-7-oxononyl)-

290

6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(2-hydroxyquinolin-3-yl)-1H-imidazol-2-

291

yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(R)-6-ethyl-N-((S)-7-oxo-1-(5-(2-oxo-1,2-dihydroquinolin-3-yl)-

292

1H-imidazol-2-yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-benzyl-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-

293

2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

294

oxononyl)-6-(pyridin-3-ylmethyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-(4-methoxybenzyl)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-

295

1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-N-(7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)-2-(2-azaspiro

297

[3.3]heptan-6-yl)acetamide

(R)-N-(7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)-2-azaspiro

298

[3.5]nonane-7-carboxamide

(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-7-

299

oxononyl)-2-azaspiro[3.5]nonane-7-carboxamide

(S)-2-(2-acetyl-2-azaspiro[3.3]heptan-6-yl)-N-(7-oxo-1-(5-phenyl-

300

1H-imidazol-2-yl)nonyl)acetamide

(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-7-

301

oxononyl)-2-(2-azaspiro[3.3]heptan-6-yl)acetamide

tert-butyl 5-(((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-

302

2-yl)-7-oxononyl)carbamoyl)-7-oxo-2,6-diazaspiro[3.4]octane-2-

carboxylate

N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-7-

303

oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-7-

304

oxononyl)-7-oxo-2,6-diazaspiro[3.4]octane-5-carboxamide

(R)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-7-

305

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-7-

306

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-2-(2-methyl-2-azaspiro[3.3]heptan-6-yl)-N-(7-oxo-1-(5-

307

phenyl-1H-imidazol-2-yl)nonyl)acetamide

(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-7-

308

oxononyl)-2-(2-methyl-2-azaspiro[3.3]heptan-6-yl)acetamide

N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-7-

309

oxononyl)-2-methyl-7-oxo-2,6-diazaspiro[3.4]octane-5-

carboxamide

(R)-2-methyl-N-(7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)-2-

310

azaspiro[3.5]nonane-7-carboxamide

(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

311

oxononyl)-2-methyl-2-azaspiro[3.3]heptane-6-carboxamide

N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

312

oxononyl)-5-methyl-5-azaspiro[2.3]hexane-1-carboxamide

N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

313

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

313

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

314

oxononyl)-2-(2-methyl-2-azaspiro[3.3]heptan-6-yl)acetamide

(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

315

oxononyl)-2-methyl-2-azaspiro[3.5]nonane-7-carboxamide

(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

316

oxononyl)-2-methyl-2-azaspiro[3.5]nonane-7-carboxamide

N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

317

oxononyl)-2-methyl-7-oxo-2,6-diazaspiro[3.4]octane-5-

carboxamide

N1-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

318

oxononyl)-6-azaspiro[2.5]octane-1,6-dicarboxamide

(R)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

320

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

321

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(R)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

322

oxononyl)-5-methyl-5-azaspiro[2.3]hexane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

323

oxononyl)-5-methyl-5-azaspiro[2.3]hexane-1-carboxamide

(1S,3S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-

324

7-oxononyl)-5-methyl-5-azaspiro[2.4]heptane-1-carboxamide

N-((S)-1-(5-(2-hydroxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

324

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-(1-(5-(2-hydroxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

326

oxononyl)-2-(2-methyl-2-azaspiro[3.3]heptan-6-yl)acetamide

(1S,3R)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-

328

7-oxononyl)-5-methyl-5-azaspiro[2.4]heptane-1-carboxamide

(1R,3S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-

329

7-oxononyl)-5-methyl-5-azaspiro[2.4]heptane-1-carboxamide

(1R,3R)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-

330

7-oxononyl)-5-methyl-5-azaspiro[2.4]heptane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

331

oxononyl)-6-propyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

332

oxononyl)-6-(3,3,3-trifluoropropyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-

333

oxononyl)-6-(2,2,2-trifluoroethyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-isobutyl-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-

335

2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-

336

1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-isopropyl-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-

337

imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-7-ethyl-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-

338

yl)-7-oxononyl)-7-azaspiro[3.5]nonane-1-carboxamide

(S)-6-ethyl-N-((S)-7-oxo-1-(5-(7-(trifluoromethyl)quinolin-3-yl)-

341

1H-imidazol-2-yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-7-oxo-1-(5-(2-oxo-6-phenyl-1,2-dihydro-

342

pyridin-3-yl)-1H-imidazol-2-yl)nonyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-ethyl-N-((S)-7-oxo-1-(5-(quinolin-7-yl)-1H-imidazol-2-

344

yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(isoquinolin-7-yl)-1H-imidazol-2-yl)-7-

345

oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-7-oxo-1-(5-(quinolin-6-yl)-1H-imidazol-2-

346

yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-methoxyquinolin-6-yl)-1H-imidazol-2-yl)-7-

347

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-1-(5-(2-methylquinolin-6-yl)-1H-imidazol-

348

2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(4-(pyridin-4-yl)phenyl)-1H-

349

imidazol-2-yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(4-(pyridin-3-yl)phenyl)-1H-

350

imidazol-2-yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(3-chloroisoquinolin-6-yl)-1H-imidazol-2-yl)-7-

351

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(quinolin-6-yl)-1H-imidazol-2-

352

yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-1-(5-(2-methyl-2H-indazol-5-yl)-1H-

353

imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(8-fluoro-2-methylquinolin-7-yl)-1H-imidazol-

354

2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-1-(5-(1-methyl-2-oxo-1,2-dihydroquinolin-

356

3-yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-methyl-N-((S)-7-oxo-1-(5-(4-(pyrazin-2-yl)phenyl)-1H-

357

imidazol-2-yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-methyl-N-((S)-1-(5-(2-methyl-1-oxo-1,2-dihydroisoquinolin-

358

6-yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(2-methyl-2H-indazol-5-

359

yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-isopropyl-N-((S)-1-(5-(2-methyl-2H-indazol-5-yl)-1H-

360

imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(S)-6-ethyl-N-((S)-1-(5-(7-methoxy-2-methylquinolin-6-yl)oxazol-

361

2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide

(1S,4r)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-

363

yl)-7-oxononyl)-1′-oxo-1′H-spiro[cyclohexane-1,3′-furo[3.4-c]

pyridine]-4-carboxamide

(1S,4r)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-

364

yl)-7-oxononyl)-1′-oxo-1′H-spiro[cyclohexane-1,3′-furo[3,4-c]

pyridine]-4-carboxamide

(1S,4r)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-

365

yl)-7-oxononyl)-7′-oxo-7′H-spiro[cyclohexane-1,5′-furo[3,4-b]

pyridine]-4-carboxamide

(1S,4r)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-

366

yl)-7-oxononyl)-5′-oxo-5′H-spiro[cyclohexane-1,7′-furo[3,4-b]

pyridine]-4-carboxamide

(1R,4s)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-

367

yl)-7-oxononyl)-7′-oxo-7′H-spiro[cyclohexane-1,5′-furo[3,4-b]

pyridine]-4-carboxamide

(1R,4s)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-

368

yl)-7-oxononyl)-5′-oxo-5′H-spiro[cyclohexane-1,7′-furo[3,4-b]

pyridine]-4-carboxamide

(S)-8-isopropyl-N-(1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadia-

369

zol-2-yl)-7-oxononyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-7-

370

oxononyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-7-

371

oxononyl)-8-(methylsulfonyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-

3-carboxamide

(1S,4r)-1′-oxo-N-((S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)-

372

1′H-spiro[cyclohexane-1,3′-furo[3,4-c]pyridine]-4-carboxamide

(1S,4r)-3′-oxo-N-((S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)-

373

3′H-spiro[cyclohexane-1,1′-furo[3,4-c]pyridine]-4-carboxamide

(1S,4r)-7′-oxo-N-((S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)-

374

7′H-spiro[cyclohexane-1,5′-furo[3,4-b]pyridine]-4-carboxamide

(1S,4r)-5′-oxo-N-((S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)-

375

5′H-spiro[cyclohexane-1,7′-furo[3,4-b]pyridine]-4-carboxamide

(1R,4s)-1′-oxo-N-((S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)

376

nonyl)-1′H-spiro[cyclohexane-1,3′-furo[3,4-c]pyridine]-4-

carboxamide

(1R,4s)-7′-oxo-N-((S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)

377

nonyl)-7′H-spiro[cyclohexane-1,5′-furo[3,4-b]pyridine]-4-

carboxamide

(1R,4s)-5′-oxo-N-((S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)

378

nonyl)-5′H-spiro[cyclohexane-1,7′-furo[3,4-b]pyridine]-4-

carboxamide

(S)-8-isopropyl-N-(7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)-1-

379

oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carboxamide

(S)-8-acetyl-N-(7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)-1-

380

oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carboxamide

methyl (S)-3-((7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)

381

carbamoyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-8-carboxylate

(S)-8-methyl-N-(7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)-1-

382

oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carboxamide

(S)-8-(methylsulfonyl)-N-(7-oxo-1-(5-phenyl-1H-imidazol-2-

383

yl)nonyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carboxamide

(S)-3-(3-ethyl-2-oxo-8-oxa-1,4-diazaspiro[4.5]dec-3-en-1-yl)-N-

384

(7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl)propanamide

(S)-N-(1-(5-(7-fluoro-1-methyl-2-oxo-1,2-dihydroquinolin-6-

386

yl)oxazol-2-yl)-7-oxononyl)-8-methyl-1-oxa-2,8-diazaspiro

[4.5]dec-2-ene-3-carboxamide

(S)-8-(cyclopropylmethyl)-N-(1-(5-(7-fluoro-1-methyl-2-oxo-1,2-

387

dihydroquinolin-6-yl)oxazol-2-yl)-7-oxononyl)-1-oxa-2,8-

diazaspiro[4.5]dec-2-ene-3-carboxamide

(S)-N-((S)-1-(5-(5-fluorobenzo[d]oxazol-6-yl)oxazol-2-yl)-7-

389

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-(1-(5-(4-chloro-2-methoxyphenyl)oxazol-2-yl)-7-oxononyl)-

390

8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carboxamide

(S)-N-(1-(5-(2-methoxy-4-(pyridin-2-yl)phenyl)oxazol-2-yl)-7-

391

oxononyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(2-methylquinolin-6-yl)-

393

1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(7-methoxyquinolin-6-yl)-

394

1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-

carboxamide

(S)-N-(1-(5-(2-methoxy-4-(pyridin-4-yl)phenyl)oxazol-2-yl)-7-

395

oxononyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

(S)-N-(1-(5-(2-(dimethylamino)-7-methoxyquinolin-6-yl)oxazol-2-

397

yl)-7-oxononyl)-8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-

carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(7-fluoro-1-methyl-2-oxo-

400

1,2-dihydroquinolin-6-yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro

[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(7-methoxyisoquinolin-6-yl)oxazol-2-yl)-7-

405

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(2-(dimethylamino)-7-methoxyquinolin-6-

406

yl)oxazol-2-yl)-7-oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-

carboxamide

N-{(1S)-1-[5-(7-methoxy-2-methylquinolin-6-yl)-1H-imidazol-2-

407

yl]-7-oxononyl}-6-oxaspiro[2.5]octane-1-carboxamide

(S)-N-((S)-1-(5-(5-methoxybenzo[d]oxazol-6-yl)oxazol-2-yl)-7-

408

oxononyl)-6-methyl-6-azaspiro[2.5]octane-1-carboxamide

N-{(1S)-1-[5-(7-methoxy-2-methylquinolin-6-yl)-1,3-oxazol-2-yl]-

409

7-oxononyl}-6-oxaspiro[2.5]octane-1-carboxamide

(S)-N-(1-(5-(7-methoxyisoquinolin-6-yl)oxazol-2-yl)-7-oxononyl)-

415

8-methyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(7-methoxy-2-methyl-

416

quinolin-6-yl)-1H-imidazol-2-yl)-7-oxodecyl)-6-azaspiro

[2.5]octane-1-carboxamide

(1S)-6-(cyclopropylmethyl)-N-{3-[4-(7-methoxy-2-methyl-

420

quinolin-6-yl)-1H-imidazol-2-yl]-9-oxoundecan-3-yl}-6-azaspiro

[2.5]octane-1-carboxamide

(S)-6-(cyclopropylmethyl)-N-((S)-1-(5-(7-methoxy-2-methyl-

422

quinolin-6-yl)oxazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-

1-carboxamide

or a pharmaceutically acceptable salt thereof.

2 . A method for the inhibition of HDAC in a subject in need thereof which comprises administering to the subject an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

3 . A pharmaceutical composition comprising an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

4 . The pharmaceutical composition of claim 3 , further comprising one or more additional therapeutic agents selected from lamivudine, abacavir, ritonavir, darunavir, atazanavir, emtricitabine, tenofovir, rilpivirine, lopinavir, doravirine and EFdA.

Assignments (2)

MERGER Recorded Aug 8, 2022

From: MERCK SHARP & DOHME CORP.

To: MERCK SHARP & DOHME LLC

Reel/Frame 061102/0145 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 26, 2021

From: YU, WENSHENG; KOZLOWSKI, JOSEPH A.; CLAUSEN, DANE JAMES; LIU, JIAN; YU, YOUNONG; WANG, MING; LI, BING

To: MERCK SHARP & DOHME CORP.

Reel/Frame 056036/0216 →

Continuity (2)

Provisional Application 62757422 · Nov 8, 2018

Related Publication 20210403479A1 · Dec 30, 2021

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