Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction
The invention provides a compound of formula I and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the formula I compounds, as well as methods of using such as therapeutic agents for the treatment of pain-related disorders and diseases and in combination with other therapeutic agents.
1. A compound selected from:
ethyl (amino((4-((ethoxycarbonyl)amino)butyl)amino)methylene)carbamate;
ethyl (4-guanidinobutyl)carbamate;
4-(2,3-bis(ethoxycarbonyl)guanidino)butylacetamide;
4-(2,3-bis(tert-butyloxycarbonyl)guanidino)butylacetamide;
4-(2-(ethoxycarbonyl)guanidino)butylacetamide;
4-(2-(ethoxycarbonyl)guanidino)butan-1-aminium 2,2,2-trifluoroacetate;
4-(2,3-bis(ethoxycarbonyl)guanidino)butan-1-aminium chloride;
4-(2,3-bis(ethoxycarbonyl)guanidino)butan-1-aminium 2,2,2-trifluoroacetate;
16-carboxy-6-((ethoxycarbonyl)amino)-4, 13-dioxo-3-oxa-5,7,12-triazahexadec-5-en-16-aminium 2,2,2-trifluoroacetate;
(16S,21R)-21-amino-16-((carboxymethyl)carbamoyl)-6-imino-4,13,18-trioxo-3-oxa-14-thia-5,7,12,17-tetraazadocosan-22-oic acid;
21-amino-16-carboxy-6-((ethoxycarbonyl)amino)-4,13,18-trioxo-3-oxa-5,7,12,17-tetraazadocos-5-en-22-oic acid; and
6-imino-4, 13-dioxo-3-oxa-5,7,12-triazatetracosane,
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising a compound as described in claim 1 and a pharmaceutically acceptable excipient.
3. A method for treating pain in an animal comprising administering the pharmaceutical composition of claim 2 to the animal.
4. A method for treating or preventing opioid analgesic tolerance, neuropathic pain, and opioid analgesic addiction in an animal comprising administering a compound as described in claim 1 , or a pharmaceutically acceptable salt thereof to the animal.
5. The method of claim 4 wherein the compound is administered intrathecally.